Term
a compound that is made of carbs and lipids, is a ceramide derivative
it functions in regulatingcell growth, development, and cell-cell interaction. ALso has a role in ABO blood group antigens. |
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Definition
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Term
| What compound is found predominately in nerve tissue, but can be seen in all body tissue. It is also found in the exterior of the plasma membrane in touch with ECM |
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Definition
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Term
| the organization of glycolipids |
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Definition
GLYCOLIPIDS
Neutral
Acidic
Gangliosides
Sulfatides |
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Term
| a type of neutral glycosphingolipid that is made of either galactose or glucose and is found primarily in the Brain and PNS |
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Definition
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Term
| a negatively charged glycosphingolipid that can be either a ganglioside or a sulfatide |
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Definition
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Term
| an acidic glycosphingolipid that has one or more negatively charged NANA moleucles. It is made of ceramide derivative and is located mostly in ganglion cells and nerve endings |
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Definition
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Term
an acidic glycosphingolipid that is composed of cerebrosides that have sulfated galactosyl residues
These are found primarily in the nerve tissue and kidney |
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Definition
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Term
| the major sulfatide found in the brain |
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Definition
| galactocerebroside 3-phosphate |
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Term
| in gamnglioside nomenclature the G stands for |
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Definition
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Term
| in gamnglioside nomenclature the M stands for |
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Definition
| the number of NANA molecules (Mono, Di, Tri) |
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Term
| in gamnglioside nomenclature the # stands for |
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Definition
| monomeric sequence of migration (1, 2, 3) |
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Term
| Where does glycosphingolipid synthesis occur |
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Definition
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Term
| what are the enzymes involved in glycosphingolipid synthesis? |
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Definition
glycosyl transferases
sulfotransferases- transfers sulfate group from PAPS |
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Term
| Major enzyme used in glycosphingolipid degradation |
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Definition
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Term
| during a defiency of glycosphingolipid degradation where is there an accumulation of glycosphingolipids |
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Definition
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Term
a general name for a defienency that occurs when a specific lysosomal enzyme is defieicent and usually one spingolipid accumulates.
It can be diagnosed by enzyme activity and DNA analysis. Also by histological examination |
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Definition
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Term
| How is sphingolipidosis treated? |
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Definition
| enzyme replacement therapy and bone marrow transplant |
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Term
| an X linked recessive disorder caused by a deficiency in a-galactosidase. Symptoms are a skin rash ans kidney failure |
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Definition
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Term
| a hexaminidase deficiency that causes symptoms of heptomegaly, neurological deterioration, and blindness |
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Definition
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Term
| an autosomal recessive sphinomylinase defiency that can be type A or type B |
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Definition
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Term
a sphiingomyelinase deficiency that is seen in infants with less that 1% enzymatic activity
Also the patients have hepatosplenomegaly and neurological degeneration |
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Definition
| Type A Niemann-Pick Disease |
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Term
| a sphingomyelinase deficiency characterized bt hepatosplenomegaly that usually a seen in adults |
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Definition
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Term
| a disorder caused by a beta-glucosidase defiency, characterized by enlarged liver and spleen, erosion of the long bone. and retardation in infants |
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Definition
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Term
| a ceramidase defiency that causes hoarseness, dermatitis, skeletal deformation, mental retardation, and is fatal early in life |
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Definition
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Term
a short lived unstored molecule, whose precursors are made of unsaturated FAs longer than 20 Cs
THe function is the mediate g proteins, regulation of smooth muscle contraction, promotion of blood clotting process, inflammatory response, and hypersensitivity |
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Definition
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Term
| Where are eicosanoids produced? |
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Definition
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Term
Produced by activated platelets
Promotes platelet aggregation and formation of blood clots
Vasoconstriction |
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Definition
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Term
Produced by endothelial cells
Inhibits platelet aggregation
Vasodilation |
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Definition
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Term
Produced by most tissues
Vasoconstriction
Smooth muscle contraction |
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Definition
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Term
Produced by hepatocytes, also in most tissues
Vasodilation
Smooth muscle relaxation |
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Definition
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Term
| this compound serves as a precursor to provide arachadonic acid 20:4(5,8,11,14) |
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Definition
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Term
| the function of these enzymes is to create 5 membered ring structure of PGG |
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Definition
| cyclooxygenase (COX) enzymes |
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Term
Constitutively expressed in all tissues
Involved in cell maintenance |
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Definition
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Term
| Inducible enzyme during inflammatory response |
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Definition
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Term
inhibit COX-1 & COX-2
Side effects: GI discomfort |
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Definition
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Term
an inhibitor of COX-2 that is used in the treatment of arthritis
Side effects: stroke and heart attack |
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Definition
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Term
| Inhibits action of acetaminophen |
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Definition
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