Term
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Definition
- production of glucose from noncarbohydrate precursors. occurs primarily in the liver.
- provides glucose to the bloodstream.
- not the same as glycolysis but has some common enzymes.
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Term
| unique enzymes for gluconeogenesis (not in glycolysis) |
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Definition
| pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase, glucose-6-phosphatase |
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Term
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Definition
| pyruvate + ATP, HCO3- -pyruvate carboxylase-> oxaloacetate |
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Term
| phosphoenolpyruvate (PEP) carboxykinase |
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Definition
| oxaloacetate + GTP -PEP carboxykinase-> PEP + GDP, CO2 |
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Term
| Fructose 1,6-bisphosphatase |
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Definition
| F1,6BP + H2O -F1,6BPase-> F6P + Pi |
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Term
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Definition
| G6P + H2O -G6Pase-> glucose + Pi |
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Term
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Definition
| PFK: up regulated by F2,6BP and AMP; down reg by ATP, citrate, H. F1,6BPase: up reg by citrate, down reg by F26BP and AMP |
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Term
| sources for gluconeogenesis |
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Definition
| pyruvate: comes from lactate and some amino acids. oxaloacetate: some amino acids. DHAP: glycerol |
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Term
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Definition
| pyruvate carboxylase. oxaloacetate must be transported to it |
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