Term
| rapid metabolizer 2C19, 2C19 metabolizes Dexilant |
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Definition
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Term
| inhibition of CYP 2D6 affecting the use of codeine |
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Definition
| NO conversion of prodrug to active metabolite |
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Term
| stopping omeprazole, a 2C19 inhibitor could affect clomipramine (2C19 substrate) |
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Definition
| substrate will not work as well because it will be metabolized more quickly after discontinuing the inhibitor |
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Term
| low sensitivity VKORC1 in relation to warfarin dose |
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Definition
| higher than normal dose of drug to be therapeutic |
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Term
| prodrug metabolized by 3A4 to active metabolite, what affects do rapid metabolizers of 3A4 have? |
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Definition
| patient would produce more active drug |
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Term
| poor metabolizer of 2C19 taking both amitriptyline and fluoxetine ...what happens? |
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Definition
| patient has much higher amitriptyline levels, poor metabolism will prevent degradation and fluoxetine inhibs metabolism even more |
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