Term
| What is the likelihood of having a child with an autosomal recessive trait |
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Definition
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|
Term
| Name 3 substances that people with the CYP2D6 polymorphism metabolise differently to people without that polymorphism |
|
Definition
Debrisquone
Haliperidol
Cardiovascular drugs |
|
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Term
| Are people with CYP2D6 polymorphism slow metabolisers of debrisquone. |
|
Definition
| Yes. They can suffer hypotension due to high drug concentration. |
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Term
| What side effects can people with CYP2D6 polymorphism suffer when taking anti-psychotics |
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Definition
| Parkinsons like due to high drug concentration as they are poor metabolisers of these drugs |
|
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Term
| What opioid pro-drug is metabolised by CYP2D6 |
|
Definition
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|
Term
| Do polymorphisms exist in alcohol dehydrogenase |
|
Definition
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|
Term
| Name the polymorphism that is associated with sulfonamide toxicities |
|
Definition
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|
Term
| How is sulphonamide toxicity manifested? |
|
Definition
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|
Term
| How might a slow acetylator be affected if given isoniazid |
|
Definition
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|
Term
|
Definition
| colon, liver, small intestine |
|
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Term
| Name the cells which rely totally on G6PDH for protection from reactive oxygen species |
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Definition
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Term
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Definition
| It produces reduced co-factor which is a source of reducing equivalents for glutathione reductase |
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Term
| Name the enzyme involved in reduction of ROS |
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Definition
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Term
| Name drugs that can cause haemolytic anaemia in G6PDH deficiency |
|
Definition
| antimalarials, sulphonamides, non-sulfa antibiotics |
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|
Term
| What is the cause of pro-longed paralysis (hours) in some patients |
|
Definition
| Atypical plasma cholinesterase |
|
|
Term
| What does TPMT stand for? |
|
Definition
| Thiopurine Methyltransferase |
|
|
Term
| What is the effect of reduced TPMT ? |
|
Definition
| High levels of 6-thioguanine nucleotides which halt cell proliferation and can suppress bone marrow causing low WBC count |
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