Term
MOA of Fluoroquinolones (FQ's)
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Definition
inhibit bacterial DNA topoisomerase IV and inhibits DNA gyrase (topoisomerase II). |
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Term
| Are FQ's concentration dependent or time dependent killing. |
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Definition
| concentration dependent killing. |
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Term
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Definition
Ofloxacin (Floxin)
Norfloxacin (Noroxin)
Ciprofloxacin (Cipro, Cipro XR, Proquin XR)
Levofloxacin (Levaquin)
Gatifloxacin (Zymar)
Moxifloxacin (Avelox, Vigamox ophthalmic)
Gemifloxacin (Factive) |
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Term
| Brand name for Ciprofloxacin |
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Definition
Cipro, Cipro XR, Proquin XR
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Term
| Brand name for Levofloxacin |
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Definition
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Term
| Brand name for Moxifloxacin |
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Definition
| Avelox, Vigamox Ophthalmic |
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Term
| Describe the antibiotic activity of Fluoroquinolones |
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Definition
Extensive activity against gram (-), gram (+) and some atypical coverage. |
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Term
| Black box warning for FQs |
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Definition
Tendon inflammation and or rupture (most often in Achilies tendon)
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Term
| Which of the FQs shouldn't be give thru a NG or other feeding tube. |
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Definition
Cipro Oral Suspension
Note: must also shake (all suspensions) for 15 seconds and not chew the microcapsules
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Term
| Which can be given via NG tube? |
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Definition
Can crush immediate release cipro tablets, mix with water and give via NG tube.
Note: hold tube feedings at least 1 hr before and 2 hours after dose.
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Term
| When should Proquin XR be given? |
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Definition
| should be given with the main meal of the day, evening meal is preferred. |
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Term
| Dose adjust in renal impairment except for which FQs? |
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Definition
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Term
| Can these agents be used in PCN - allergies? |
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Definition
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Term
FQs can increase the levels of warfaring, sulfonylureas and QT - prolonging drugs.
Probenecid and NSAIDs can increase FQ levels.
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Definition
| Statement. Not a question. |
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Term
| Which FQ is a potent 1A2 inhibitor? |
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Definition
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