Term
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Definition
| synthetic, wide antibacterial spectrum, favorable pharmacokinetic properties, few AE, but emerging resistance. TX for UTIs |
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Term
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Definition
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Term
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Definition
| 2nd gen fluoroquinolone- PO/IV. prototype |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| 4th gen fluoroquinolone- fatal hepatotoxicity- withdrawn from US market. |
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Term
| Diarrhea, Nausea, HA, dizziness, light-headed, crystalluria, rash, articular cartilage erosion. CI- preggo, lactation, renal damage. |
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Definition
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Term
| UTI, prostatitis; resp tract infection; STD (gonorrhea, not syphilis); GI infections; bone, joint, & soft tissue infections; multidrug resistant TB & atypical mycobacterial infections |
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Definition
| Therapeutic uses fluoroquinolones |
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Term
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Definition
| Urinary tract antiseptic- breaks down formaldehyde which kills the bugs. TX chronic cystitis |
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Term
| Nitrofurantoin (macrobid) |
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Definition
| Urinary tract antiseptic- less common, narrow spectrum, toxic. Bacteriostatic. turns urine brown. |
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Term
| GI disturbances, acute pneumonitis, hemolytic anemia, agranulocytosis, hepatotoxic, pancreatitis |
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Definition
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Term
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Definition
| Antimcobacterial- TX against Tb. bactericidal against extracellular and intracellular growing bacilli. interferes with biosynthesis of cell wall mycolic acids |
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Term
| Peripheral neuritis, hepatotoxicity, potential for seizures, inhibit metabolism phenytoin, hypersensitivity- rash, fever |
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Definition
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Term
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Definition
| antimycobacterial- bactericidal against extracellular cavitary bacili & organisms in closed lesions. inhibits bacteral DNA-dependent RNA polymerase |
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Term
| hypersensitivity, epigastric distress, NVD, cramps, fever; hepatotoxicity & jaundice, turns saliva, tears, urin, sweat orange/red color. Drug interactions- induces CYP450 |
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Definition
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Term
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Definition
| antimycobacterial- bacteriocidal. absorbed orally, distributed throughout body & CSF. excreted by kidney. |
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Term
| Hepatotoxic, hyperuricemic, ocassional GI |
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Definition
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Term
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Definition
| antimycobacterial- bacteriostatic. used in combination. oral, distributed through & CSF. kidney excretion |
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Term
| Optic neuritis, urate retention & gouty attacks |
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Definition
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Term
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Definition
| antimycobacteral- bacteriocidal to extracellular TB. problem with resistance, use in combo. |
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Term
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Definition
| Leprosy- sulfonamide related PABA antagonist. bacteriostatic. |
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