Term
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Definition
| Block AT1 (angiotensin II subtype I) receptors, prevents constriction of arterioles. |
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Term
| ACE-I (angiotensin converting enzyme inhibitor)effect; side effect. |
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Definition
| decreases angiotensin levels, less sodium and water absorbed and lower blood pressure; increased bradykinin (inactivated by ACE), which also decreases bp thru NO release and vasodilation BUT is a PRO-inflammatory cytokine (irritation of lungs = cough) |
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Term
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Definition
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Term
| Captopril and lisinopril, side effect? |
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Definition
| only prils that aren't PROdrugs (which must be metabolized to activate); captopril contains S = allergic rxn and CAI, metallic/loss of taste, short half life (2-3 hr, others > 12 hr) |
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Term
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Definition
| ARBs (angiotensin II subtype I receptor blockers) |
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Term
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Definition
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Term
| ACE-I and ARB side effects |
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Definition
1) dry cough (increase bradykinin)
2)angioedema (vasodilation/serious if involves airways)
3)hyperkalemia (no Na resorbed, K remains in blood)
*all less common with ARBs |
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Term
| ACE-I and ARB contraindications |
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Definition
1) Bilateral renal artery stenosis i.e. low RPF (unilateral if only one functioning kidney)...start with low dose and monitor serum creatinin
2)hx of angioedema
3)pregnancy (fetal hypotension, malformations, renal failure, death) |
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Term
| Added advantages of -prils (ACE-Is) |
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Definition
1) cardioprotective (less stroke, MIs)
2) protection against diabetes and nephropathy associated with diabetes |
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Term
| Drugs combined with -prils (ACEIs) and -sartans (ARBs) |
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Definition
| other hypertension drugs (diuretic hydrochlorothiazide which decreases K; calcium channel blockers [with ACEIs] like verapamil which vasodilate arteries) |
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Term
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Definition
direct renin inhibitor
(like a beta 1 blocker: found in kidneys) |
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