Term
| what are the antiresorptive meds |
|
Definition
| bisphosphonates, SERMs, calcitonin |
|
|
Term
anabolic therapy promotes
waht is the med |
|
Definition
bone formation
teriparatide |
|
|
Term
for kidney failure what vit d supplment can be used?
why? |
|
Definition
DHT
doesnt need 1a hydroxylation |
|
|
Term
| what is currently not approved as Vit D supplment |
|
Definition
|
|
Term
| enahnced Vit D clearence/ bad metabolism-> bone sofetning leads to |
|
Definition
|
|
Term
what meds cause Vit d clereance
what disease state? |
|
Definition
pheytoin, phoenoarbital, carbamazapine, rifampin;
hepatic |
|
|
Term
|
Definition
|
|
Term
| bisphosphonates are P-C-P analogs of |
|
Definition
|
|
Term
| what are the 2 main bisphosphonates |
|
Definition
|
|
Term
| which class of meds are incorporated into the bones |
|
Definition
|
|
Term
| 1st generation BPS reduce resopriton by increasing _ |
|
Definition
|
|
Term
| 2nd generation(amino) BPs reduce resorption by inhibiting 2 things |
|
Definition
| osteoclast funciton and isoprenoid lipid ynth |
|
|
Term
| BPs increase _ and reduce risk of |
|
Definition
|
|
Term
| BPs are polar and high/low absoprtion from GI |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| esophageal distress, naseua |
|
|
Term
|
Definition
|
|
Term
| simple BPs form _ antimetabolites |
|
Definition
|
|
Term
| which is mroe potent simple or Nitrogen BPs |
|
Definition
|
|
Term
| nitrogen BPs inhibit _ synthase |
|
Definition
|
|
Term
| isoprenoid lipids are needed for prenylation of _ |
|
Definition
| small GTPases-ras, rho, rab |
|
|
Term
| prenylates small GTPases are needed fro |
|
Definition
|
|
Term
| what two small GTPases affected by N containing BPs are anti-OP |
|
Definition
|
|
Term
what GTPase inhibits osteoclast traffic?
which deos apoptosis |
|
Definition
|
|
Term
|
Definition
|
|
Term
raloxifene is estrogen agonist in _
antagonist in _ |
|
Definition
bone
breast and endometrial |
|
|
Term
| raloxifene reduces _ type of fractures |
|
Definition
|
|
Term
| raloxifene reduces _ cancer adn doesnt cause _ cancer |
|
Definition
|
|
Term
| SERMs most common side afect |
|
Definition
|
|
Term
| what SERMs are not approved for OP |
|
Definition
|
|
Term
| what med is the recombinant of PTH |
|
Definition
|
|
Term
| continuous exposure to PTH is bad bc causes |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what populaitons is terparatide not reccomended |
|
Definition
| children or paget's disease |
|
|
Term
| do not use teriparatide in pateints with what disease state |
|
Definition
|
|
Term
| max perriod of use of teriparatide |
|
Definition
|
|
Term
|
Definition
|
|
Term
| where is calcitonin synth |
|
Definition
| prarfollical C cells of thyroid |
|
|
Term
| calcitonin works on osteoclasts how- |
|
Definition
| binds to receptr, reduces border surface osteoclasts and reduces acticity |
|
|
Term
| calcitonin work on _ to promote Ca excretion |
|
Definition
|
|
Term
| salmon calcitonin is more/less potent, longer lasting than human |
|
Definition
|
|
Term
| side affects of calictonin |
|
Definition
| rhinitis , nsal irriation |
|
|
Term
| which med is given intrnasal |
|
Definition
|
|
Term
|
Definition
|
|
Term
| soluble form of RANKL is formed by 2 ways |
|
Definition
secreted by 2 cells
cleaved from osteoblast |
|
|
Term
what is the recepotr for RANKL
where is it loacted |
|
Definition
RANK
trnasmembran of osteoclast precursors |
|
|
Term
|
Definition
|
|
Term
| TRAF 6 carries signals thru what 2 cascades |
|
Definition
|
|
Term
| what is the natural inhibitor of RANKL |
|
Definition
|
|
Term
| what is a human Mab medicaiton agaisnt RANKL |
|
Definition
|
|
Term
| what does denosumab act like |
|
Definition
|
|
Term
| Denosumab is used for _ OP in what population |
|
Definition
|
|
Term
| MOA of denosumab is 2 things |
|
Definition
reduces resorption
suppresses bone turnover |
|
|
Term
dosing fro denosumab
how is it admin |
|
Definition
60 mg q 6 months for 3 yrs
subQ |
|
|
Term
| some dise affects of denosumab |
|
Definition
|
|
Term
| denosumab is contraindicated in - 5 |
|
Definition
preggo
hypocalcemia
serious infections
liverr disease
children |
|
|
Term
| what is the transdermal gel med |
|
Definition
|
|
Term
| androgens see increase BMD in 2 pops |
|
Definition
men with hypogonads
OP women |
|
|
Term
| testosterone contraindicated in men with |
|
Definition
|
|
Term
|
Definition
| weight gain, acne, testical atrophy |
|
|
Term
| Ca supplements readily availabel where |
|
Definition
|
|
Term
| absoprtion of Ca increases/decreases with tablet size increase |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| constipation, gas, upset stomach |
|
|
Term
| Ca supplment can decrease absorption of - 3 things |
|
Definition
iron
tetracyclines
phenytoin |
|
|
