Term
|
Definition
NA channel blockade
Decreases CV
Increases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Decreases CV
Increases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Decreases CV
Increases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Little effect on CV
Decreases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Little effect on CV
Decreases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Little effect on CV
Decreases ERP + APD |
|
|
Term
|
Definition
NA channel blockade
Little effect on CV
Decreases ERP + APD
AND
Drastically decreases CV |
|
|
Term
|
Definition
NA channel blockade
Drastic effect on CV |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
|
Definition
K channel blockade
Increase APD and ERP |
|
|
Term
| What class of CCB antiarrhythmic drugs are not used? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| What factor are LMWH drugs selective for? |
|
Definition
|
|
Term
|
Definition
| Accelerator of antithrombin III |
|
|
Term
| Orally effective anticoagulant (2) |
|
Definition
|
|
Term
| What factor is rivaroxaban selective for? |
|
Definition
|
|
Term
| Direct thrombin inhibitors (3) |
|
Definition
"Rubin"
Argatroban
Dabigatran |
|
|
Term
| Inhibitor of COX (antiplatelet drug) |
|
Definition
|
|
Term
| Inhibitor of PDE (antiplatelet) |
|
Definition
|
|
Term
| Platelet ADP receptor inhibitors (2 groups) |
|
Definition
"clop" "grel"
EX. Ticlopidine
Clopidogrel
Prasugrel |
|
|
Term
| Glycoprotein IIb/IIIa inhibitors (3) |
|
Definition
"fib" "ban"
Abciximab
Eptifibatide
Tirofiban |
|
|
Term
| Treatment of thrombocythemia |
|
Definition
|
|
Term
|
Definition
| Treatment for claudication (leg cramps) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Antidote to fibrinolytic drugs |
|
Definition
| Aminocaproic acid/tranexamic acid |
|
|
Term
|
Definition
Organic nitrates
Variety of dosage forms |
|
|
Term
|
Definition
| Inhalation organic nitrate |
|
|
Term
|
Definition
| Long acting organic nitrate |
|
|
Term
| What two classes of drugs are great for angina? |
|
Definition
|
|
Term
| Increased uptake of LDL by liver because of increased LDL receptor levels |
|
Definition
|
|
Term
| drugs that prevent bile acid resportion |
|
Definition
| bile acid resigns ("chol") |
|
|
Term
| What drug along with statin increases risk for rhabdomyolysis |
|
Definition
|
|
Term
| What drug works in intestine to block absorption of cholesterol |
|
Definition
|
|
Term
| what drugs enhance lipoprotein lipase clearance |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| best on lowering triglycerides |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| hemolytic anemia from primaquine |
|
|
Term
|
Definition
| neuropathy at isonizid or drug induced lupus from hydralizine |
|
|
Term
|
Definition
| drug induced jaundice (decrease metabolism from APAP and lorezapam) |
|
|
Term
|
Definition
| maximum response (drugs with same effect but difference MAO) |
|
|
Term
| drug that acts by opening K channels in vascular smooth muscle |
|
Definition
|
|
Term
| if person has fluid in lungs what drug should you not use? |
|
Definition
|
|
Term
| what drug produces beneficial effect on renal circulation in treatment of hypertensive crisis? |
|
Definition
|
|
Term
| adverse effect of sodium nitroprusside |
|
Definition
|
|
Term
| If k is low what drug would relieve symptoms |
|
Definition
| eplerenone (or spiralonactone) |
|
|
Term
| second phase asthma response in ER? |
|
Definition
|
|
Term
| begin treatment if having an ER asthma attack? |
|
Definition
| inhaled SABA (terbutaline) |
|
|
Term
| What drug inhibits NE release by blocking uptake into storage vesicles in synapse? |
|
Definition
|
|
Term
| drug that inhibits lipoxygenase |
|
Definition
|
|
Term
| trouble focusing on magazine is because of |
|
Definition
| relaxation of ciliary muscle |
|
|
Term
| What drugs prevent the destruction of cateocholamines |
|
Definition
|
|
Term
|
Definition
| increase TPR but decrease CO |
|
|
Term
| alpha antagonists effect on TPR and CO |
|
Definition
| decrease TPR but slight increase in CO (accounts for orthostatic hypotension) |
|
|
Term
| best CCB treatment for SVT |
|
Definition
|
|
Term
| best CCB treatment for angina |
|
Definition
|
|
Term
|
Definition
|
|
Term
| best CCB for isolated systolic hypertension |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Vasodilators effect on TPR and CO |
|
Definition
| decresae TPR but significantly increase CO |
|
|
Term
|
Definition
|
|
Term
|
Definition
| decrease in TPR but increase CO (similar to alpha blockers) |
|
|
Term
| Verapamils effect on TPR and CO |
|
Definition
|
|
Term
| diltizem effect on TPR and CO |
|
Definition
| decrease TPR and no effect on CO |
|
|
Term
| what CCB are contraindicated in bradyarrithymias |
|
Definition
|
|
Term
| what CCB are contraindicated in tachyarrithymias |
|
Definition
|
|
Term
| diuretic use in acute renal failure and edema |
|
Definition
|
|
Term
|
Definition
|
|
Term
| diuretic useful for hypercalcemia |
|
Definition
| loop (semide or bumetanide) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| triameterene is an example of |
|
Definition
|
|
Term
| amiloride is an example of |
|
Definition
|
|
Term
| "vaptan"s are examples of |
|
Definition
|
|
Term
| ADH antagonists do what to water and Na |
|
Definition
| decrease water, increase Na |
|
|
Term
|
Definition
| ADH antagonists (vaptans) |
|
|
Term
| inihibitor of tumor necrosis factor |
|
Definition
|
|
Term
| NE is a weak agonist at what receptors |
|
Definition
|
|
Term
| There is decreased NE release at what receptor? |
|
Definition
|
|
Term
| What drug would restore neuromusclar transmission? |
|
Definition
| Neostigmine, pyrostigmine |
|
|
Term
| Prempro increases the risk for |
|
Definition
|
|
Term
| Raloxefine increases the risk for |
|
Definition
|
|
Term
| Tamoxifen increases the risk for |
|
Definition
|
|
Term
| Anastrozole is an example of a |
|
Definition
|
|
Term
| Anastrozole increases the risk for |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| If blood sugar falls, the level of insulin will not return very quickly with what drug? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What stimulates insulin release? |
|
Definition
|
|
Term
| What decreases insulin resistance? |
|
Definition
| sensitizers (metformin, glitazones) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| liver toxicity -- check monthly |
|
|
Term
| What drugs act through zero order metabolism? |
|
Definition
| Aspirin, phenytoin, unfractionated heparin |
|
|
Term
| Does heparin have an effect on clotting times? |
|
Definition
|
|
Term
| What exacerbates thrombocytopenia? |
|
Definition
| Warfarin (because of protein C inhibition (factors 5 and 8)) |
|
|
Term
| What does the 18 saccharide sequence bind to? |
|
Definition
|
|
Term
| What is gamma carboxylation of glutamic acid unable to complex with if no vit K? |
|
Definition
|
|
Term
| What is the onset of action for warfarin? |
|
Definition
|
|
Term
| Why are prothrombin time and INR used to monitor the onset of anticoagulation for warfarin? |
|
Definition
| factor 7 turnover is the fastest |
|
|
Term
| What drugs are used when thrombocyopenia are present? |
|
Definition
| Direct thrombin inhibitors (rudin, argatroban, dabigatran) |
|
|
Term
| What class of drugs prevents thrombi in the arterial blood? |
|
Definition
|
|
Term
| What does COX inhibition in platelets prevent? (aspirin) |
|
Definition
|
|
Term
| What does COX inhibition in endothelial cells prevent? (aspirin) |
|
Definition
|
|
Term
| In dipyridamole, what does increasing cAMP do to platelets? |
|
Definition
| makes it so they won't release their contents |
|
|
Term
| Examples of ADP receptors |
|
Definition
|
|
Term
| What antiplatelet drug binds to plasma proteins? |
|
Definition
|
|
Term
| What antiplatelet drug causes potential life threatening neutropenia and blood dyscrasias? |
|
Definition
|
|
Term
| Examples of 2B 3A glycoprotein inhibitors? |
|
Definition
|
|
Term
| Treatment for thrombocythemia? |
|
Definition
|
|
Term
| What does anagrelide inhibit the development of? |
|
Definition
|
|
Term
| A protease that degrades fibrin? |
|
Definition
|
|
Term
| What drugs are plasminogen activators? |
|
Definition
|
|
Term
| Are first generation fibrinolytic drugs fibrin specific? |
|
Definition
|
|
Term
| What antifibrinolytic drug forms a 1:1 complex with plasminogen, exposing an active site that activates additional plasminogen into plasmin? |
|
Definition
|
|
Term
| What antifibrinolytic drug activates plasminogen directly? |
|
Definition
|
|
Term
| What antifibrinolytic drug is converted to a two chain t-PA dimer upon exposure to fibrin? |
|
Definition
|
|
Term
| What binding interactions do antifibrinolytic drugs block? |
|
Definition
|
|
Term
| What are antifibrinolytic drugs used for? |
|
Definition
| dental procedures in hemophiliacs to control bleeding |
|
|
Term
| What is coronary blood flow determined by? |
|
Definition
|
|
Term
| 3 passive factors of angina |
|
Definition
| venous/arterial pressure gradient, duration of diastole, LVEDP |
|
|
Term
| The intrinic ability of the coronary bed to maintain constant CBF in presence of changes in perfusion pressure is called |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Wall tension, heart rate, contractility (all increase your need for O2) |
|
|
Term
| Does an increased pO2 cause vasodilation or constriction? |
|
Definition
|
|
Term
| What pathway shunts blood from the normal zone to the ischemic zone in angina |
|
Definition
|
|
Term
| Does venous dilation (preload reduction) increase supply or decrease demand? (angina) |
|
Definition
|
|
Term
| Does arterial dilation in angina decrease demand or increase supply of O2 |
|
Definition
|
|
Term
| 3 main classes of drugs in treat angina |
|
Definition
|
|
Term
| Where are the two main places L type Ca channels are found? |
|
Definition
| Heart tissue (stable) and vascular smooth muscle (Variant angina) |
|
|
Term
| AV node >> myocardium >> VSM |
|
Definition
|
|
Term
| VSM >> myocardium >> some AV node effect |
|
Definition
|
|
Term
| VSM >> myocardium >> no AV node effect |
|
Definition
|
|
Term
| What other angina drug should be combined with verapamil to offset drastic reduction in contractility |
|
Definition
|
|
Term
| What antianginal drug blocks late Na channels |
|
Definition
|
|
Term
| For anti arrhythmic drugs, what are the better effects, direct or indirect? |
|
Definition
|
|
Term
| In cardiac glycosides, what are the better effects, indirect or direct? |
|
Definition
|
|
Term
| What two drugs can treat digitalis induced arrhythmias? |
|
Definition
|
|
Term
| What antiarrthymic drug has proarrithymic effects? |
|
Definition
|
|
Term
| What CCB are not used with arrythmias |
|
Definition
|
|
Term
| What group of drugs inhibit Na K ATPase to increase Na and therefore Ca |
|
Definition
|
|
Term
| What do cardiac glycosides do to SV |
|
Definition
|
|
Term
| When you increase SV, what effect is that? |
|
Definition
|
|
Term
| inamirinone and milrinone are examples of |
|
Definition
| phosphodiesterase inhibitors |
|
|
Term
| Two examples of adrenoceptor agents used in treating CHF? |
|
Definition
| dopamine and dobutamine (inotropes) |
|
|
Term
| What CCB is not used in CHF? |
|
Definition
|
|
Term
|
Definition
| Diuretics, ACE, BB, vasodilators, glycosides, nesiritide, inotropes |
|
|
Term
| Cardiac glycosides are contraindicated in people with |
|
Definition
|
|
