Term
|
Definition
| short duration benzodiazepine (anesthesia) |
|
|
Term
|
Definition
| intermediate duration benzodiazepine (hypnotic, anxiolytic, anesthesia, withdrawal suppressant, status epilepticus) |
|
|
Term
|
Definition
| intermediate duration benzodiazepine (anxiolytic) |
|
|
Term
|
Definition
| long duration benzodiazepine (anxiolytic, anticonvulsant, anesthesia, withdrawal suppressant, muscle relaxant) |
|
|
Term
|
Definition
| intermediate duration barbituate (hypnotic-insomnia) |
|
|
Term
|
Definition
| intermediate duration barbituate (hypnotic-insomnia) |
|
|
Term
|
Definition
| ultra short duration barbituate (anesthesia) |
|
|
Term
|
Definition
| partial 5-HT1A receptor agonist (anxiolytic, hypnotic-insomnia, muscle relaxant--especially in patients with history of drug abuse) |
|
|
Term
|
Definition
| enhance GABA effects (hypnotic-insomnia) |
|
|
Term
|
Definition
| enhance GABA effects (hypnotic-insomnia) |
|
|
Term
|
Definition
| enhance GABA effects (hypnotic-insomnia) |
|
|
Term
|
Definition
| melatonin receptor agonist (sleep aid) |
|
|
Term
|
Definition
| benzodiazepine antagonist (post anesthesia, benzo poisoning) |
|
|
Term
|
Definition
| GABA analog at GABA-B receptors in spinal cord (spasticity from MS and spinal cord injuries) |
|
|
Term
| cyclobenzaprene (flexeril) |
|
Definition
| inhibits gamma and alpha motor systems (muscles spasms of local origin--strains) |
|
|
Term
|
Definition
|
|
Term
| chlorpromazine (throrazine) |
|
Definition
| low potency phenothiazine--D2 antagonist (antipsychotic) --sedation, CV, AC effects |
|
|
Term
| fluphenazine (prolixin, prolixin decanoate) |
|
Definition
| high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects |
|
|
Term
| trifluoperazine (stelazine, suprazine) |
|
Definition
| high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects |
|
|
Term
| haloperidol (haldol, haldol decanoate) |
|
Definition
| high potency NONphenothiazine--D2 antagonist (antipsychotic) --EPS effects |
|
|
Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (2nd line therapy as antipsychotic) --grunulocytopenia, agranulocytosis, seizures, metabolic SE's |
|
|
Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) --AC effects, metabolic SE's |
|
|
Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (widely used antipsychotic) --metabolic SE's |
|
|
Term
|
Definition
| 2nd gen atypical antipsychotic--Partial AGONIST/ANTAGONIST at D2 and 5-HT1a (antipsychotic) |
|
|
Term
|
Definition
| 2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) |
|
|
Term
| imipramine (tofranil, janimine) |
|
Definition
| tricyclic--inhibits reuptake of NE and 5HT (BED WETTING, pain, 2nd line tx for depression) --decreases BETA receptors, AC and CV effects |
|
|
Term
|
Definition
| tricyclic--inhibits reuptake of NE and 5HT (pain, 2nd line tx for depression) --worst AC effects |
|
|
Term
|
Definition
| SSRI (depression, OCD, anxiety, PMDD, bulimia, anorexia) --drug interactions |
|
|
Term
|
Definition
|
|
Term
|
Definition
| SSRI (OCD, depression) --short half life, wt gain |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
venlafaxine (effexor)
desvenlafaxine (pristiq) |
|
Definition
| SNRI--inhibits reuptake of NE, 5HT, and DA (depression, anxiety) --stimulant activity, decreased BETA receptors |
|
|
Term
|
Definition
| 2nd gen antidepressant--inhibits reuptake of 5HT, also blocks 5HT-2 receptors (depression) --PRIAPISM, sedating |
|
|
Term
|
Definition
| 2nd gen antidepressant--inhibits DA reuptake (depression, nicotine/cocaine/amphetamine addictions) --SEIZURES |
|
|
Term
|
Definition
| selective NE reuptake inhibitor (ADHD) --decreases BETA receptors, INCREASED BP |
|
|
Term
|
Definition
| MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma |
|
|
Term
| tranylcypromine (parnate) |
|
Definition
| MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma |
|
|
Term
| lithium carbonate (eskalith) |
|
Definition
| mood stabilizer--alters phosphoinositol pathway? (manic depressive disorders) --hypothyroidism, nephrotoxic, teratogenic, toxicity=drunkenness |
|
|
Term
| valproic acid analogs (depakene/depakote) |
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
|
|
Term
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
|
|
Term
|
Definition
| antiepileptic (epilepsy, manic depressive disorders) |
|
|
Term
| L-DOPA (larodopa, sinemet) |
|
Definition
| dopamine precursor (parkinsons) |
|
|
Term
|
Definition
| DOPA decarboxylase inhibitor in periphery (combo with L-DOPA for parkinsons) |
|
|
Term
|
Definition
| ergot derivative--nonspecific DA receptor agonist (parkinsons) |
|
|
Term
|
Definition
| non-ergot dopamine receptor agonist (parkinsons, restless leg syndrome) |
|
|
Term
|
Definition
| non-ergot dopamine receptor agonist (parkinsons, restless leg syndrome) |
|
|
Term
|
Definition
| stimulates dopamine release (parkinsons, antiviral) |
|
|
Term
| selegiline/deprenyl (eldepryl, zelapar) |
|
Definition
| MAO-B inhibitor--prevents DA breakdown in CNS (late parkinsons) |
|
|
Term
|
Definition
| COMT inhibitor--inhibits metabolism of DA (parkinsons) |
|
|
Term
|
Definition
| anticholinergic (iatrogenic parkinsonism--drug induced) |
|
|
Term
| diphenhydramine (benadryl) |
|
Definition
| antihistamine w/ anticholinergic activity (iatrogenic parkinsonism) |
|
|
Term
|
Definition
| mu opioid agonist (severe pain) |
|
|
Term
| hydromorphone (dilaudid, palladone) |
|
Definition
| mu opioid agonist (severe pain) |
|
|
Term
|
Definition
| opioid, mild-moderate pain, antitussive |
|
|
Term
| oxycodone (roxicodone, percodan, oxycontin) |
|
Definition
| opioid, moderate-severe pain, oxycontin for severe chronic pain |
|
|
Term
| hydrocodone (lortab, lorcet, vicodin, norco) |
|
Definition
| opioid, mild-moderate pain, antitussive |
|
|
Term
|
Definition
| opioid, moderate-severe pain |
|
|
Term
| heroin (diacetylmorphine) |
|
Definition
| opioid,more potent and euphoric than morphine |
|
|
Term
|
Definition
| opioid, analgesic and treatment for opioid addiction |
|
|
Term
| fentanyl (sublimaze, duragesic, innovar) |
|
Definition
| opioid, very potent mu agonist (surgical anesthesia, transdermal prep for chronic pain, lozenge for breakthrough pain) |
|
|
Term
|
Definition
| opioid, kappa agonist, partial mu agonist (severe pain) |
|
|
Term
| buprenorphine (buprenex, subutrex, suboxone) |
|
Definition
| opioid, partial mu agonist (office based opioid addiction) |
|
|
Term
|
Definition
| opioid, weak mu agonist, inhibits reuptake of NE and serotonin (mild-moderate pain) |
|
|
Term
|
Definition
| opioid antagonist (opioid poisoning) |
|
|
Term
|
Definition
| long acting opioid antagonist ("immunizing" addicts, alcoholism) |
|
|
Term
| valproic acid (depakote, depakene) |
|
Definition
| increases GABA synthesis, modulates glutamate and inhibits sodium channel reactivation and T-type Ca+ channels (prophylaxis of migraine, absence, myoclonic, partial and tonic/clonic seizures) |
|
|
Term
|
Definition
| facilitates GABA neurotransmission, modulates glutamate and inhibits sodium and calcium channel activity (prophylaxis of migraine, partial seizures, neuropathic pain) |
|
|
Term
|
Definition
| long acting barbituate--GABA receptor agonist (generalized tonic-clonic and partial seizures, status epilepticus) |
|
|
Term
| Phenytoin (dilantin, diphenylan) |
|
Definition
| prolong recovery rate of voltage-gated Na+ channels (generalized tonic-clonic and partial seizures, status epilepticus) |
|
|
Term
| carbamazepine 1974 (tegretol, carbatrol) |
|
Definition
| prolong recovery rate of voltage-gated Na+ channels (generalized tonic-clonic and partial seizures, manic-depressive patients) |
|
|
Term
| ethosuximide 1960 (zarontin) |
|
Definition
| inhibits T-type Ca+ channels (absence seizures) |
|
|
Term
| lamotrigine-1994 (lamictal) |
|
Definition
| prolong recovery rate of voltage-gated Na+ channels (partial and generalized tonic/clonic seizures, "broad spectrum" AED) |
|
|
Term
|
Definition
| maybe acting on cannabinoid receptors in brain (recreational) --lipid soluble, suppresses immune fxn, decreased testosterone, teratogenic, amotivational syndrome, lung damage |
|
|
Term
|
Definition
| (nausea and vomiting during chemo, prevention of wasting in AIDS, maybe useful in glaucoma and asthma) |
|
|
Term
|
Definition
| non-depolarizing NMJ blocker -intermediate duration (GA adjunct) --apnea, histamine release, use in patients with LIVER or RENAL failure |
|
|
Term
|
Definition
| non-depolarizing NMJ blocker -intermediate duration (tracheal intubation) |
|
|
Term
| succinylcholine (anectine) |
|
Definition
| depolarizing NMJ blocker -opens nicotinic ACh receptors allowing Na influx and slightly depolarizing neuron (short procedures such as rapid intubation) --initial fasciculations |
|
|
Term
|
Definition
| amide LA -inhibits voltage gated Na channel (infiltration, nerve block, spinal, epidural, topical, IV, MOST USED) |
|
|
Term
|
Definition
| long duration amide LA-inhibits voltage gated Na channel mainly on sensory neurons (LABOR) |
|
|
Term
|
Definition
| amide LA-inhibits voltage gated Na channel (anesthesia) --prolonged numbness |
|
|
Term
| benzocaine (americaine, hurricaine, chloraseptic) |
|
Definition
| ester LA-inhibits voltage gated Na channel (topically for surface anesthesia) --methemoglobinemia!!!!! |
|
|
Term
|
Definition
| ester LA-inhibits voltage gated Na channel (topical use only) --abuse potential, nervousness, convulsions, cardiac failure, only LA with VASOCONSTRICTIVE effect |
|
|
Term
| lysergic and diethylamide (LSD) |
|
Definition
| indole hallucinogen--presynaptic 5HT agonist (trippin) --sympathomimetic, psychic changes, sensory distortions |
|
|
Term
| methylenedioxymethamphetamine (MDMA; ecstasy) |
|
Definition
| phenylethylamine hallucinogen w/ amphetamine like effects--presynaptic 5HT agonist (trippin) --sympathomimetic, psychic changes, sensory distortions |
|
|
Term
| phencyclidine (PCP; angel dust; KETAMINE) |
|
Definition
| hallucinogen/stimulant at high doses--NMDA antagonist (trippin) --psychotic rxns, hyperreflexia, increased muscle tone, hypertension, VERTICAL NYSTAGMUS |
|
|
Term
| d-amphetamine, d,l-amphetamine (adderall) |
|
Definition
| mixture of amphetamine salts--stimulates release and inhibits reuptake of NE and DA (ADHD) --sympathomimetic, tremors, appetite suppression |
|
|
Term
|
Definition
| inhaled general anesthetic-weak, but rapid induction and recovery (induce analgesia) --colorless, odorless, air pocket expansion, depress ventillation |
|
|
Term
|
Definition
| inhaled GA-potent, but slow induction (analgesia) --sweet odor, decrease in BP, contractility, and vent. rate, produces electrical SEIZURE activity |
|
|
Term
|
Definition
| inhaled GA-slow induction (analgesia) --pungent odor, decreases BP, vent rate, metabolic rate of brain, and renal blood flow; preferred for NEUROSURGERY |
|
|
Term
|
Definition
| inhaled GA-rapid induction (maintain analgesia) --irritating to lungs, so not used for induction; decrease BP and vent rate |
|
|
Term
|
Definition
| inhaled GA-rapid induction (induce/maintain analgesia) --decrease BP; preferred for patients prone to MI; reacts with soda lime |
|
|
Term
|
Definition
| IV GA-enhances GABA effects (induce anesthesia, most commonly used) --decreases BP, contractility, and vent rate; anti-emetic, safe in pregnant |
|
|
Term
|
Definition
| IV GA-NMDA antagonist, inhibits voltage sensitive Na/K channels (profound analgesia in battlefield/vet medicine) --emergence delirium, hallucinations, bronchodilator, increases CO, BLADDER deterioration in addicts |
|
|
