Term
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Definition
| Mechanical, protective, organization |
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Term
| What is the second step of extracellular protein formation? |
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Definition
| Hydroxylation which occurs commonly on praline and hydroxylysine |
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Term
| What enzyme causes Hydroxylation of praline and lysine? |
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Definition
| prolyl or Lysol hydroxylase. The cofactor is vitamin C. Scurvy. |
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Term
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Definition
| Glycosylation. Hydroxylysine ad asparagine are glycosolated (galactose/glucose added). |
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Term
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Definition
| Disulfide bond formation at the C terminus align the three alpha chains before the triple helix |
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Term
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Definition
| The central protons of the chains zipper from C- to Ne-terminus to form the triple helix. |
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Term
| What is immature collagen called? |
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Definition
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Term
What are the n- and c- terminals called
/ |
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Definition
|
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Term
|
Definition
| tropocollogen molecules spontaneously assemble into a fibrin with holes. |
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Term
| What stabilizes the collagen maturation? Step 9? |
|
Definition
| Cross inks between aldehyde. (lysyl oxidase) |
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Term
|
Definition
| Stretchy skin, joints. 1. Deficient collagen fibrin formation. (defective peptidase) 2. Deficient crosslinking in collegian.(lysil oxidase) |
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Term
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Definition
| Lungs, skin, blood vessels |
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Term
| What elastin core is necessary for elastin? |
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Definition
| fibrillin. Crucial for integrity of elastic fibers. |
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Term
|
Definition
| Elastic fibers are weak, tall, crowded teeth, chest abnormalities, anyuerisns |
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Term
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Definition
| Long unbranched polysaccharides consisting of Disaccharides. |
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Term
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Definition
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Term
| Gags are hydrophilic. What happens in water? |
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Definition
| h20 sucked into matrix and a gel forms. |
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Term
| What is an example of gags: |
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Definition
|
|
Term
| proteoglycans are found where? |
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Definition
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|
Term
| What disease is associated with proteoglycans |
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Definition
|
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Term
| What is wrong with PROTEOGLYCANS in osteoarthritis? |
|
Definition
| Decreased GAG synthesis by chondroblasts. Decreases PROTEOGLYCANS made from gags. |
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Term
| What type of collagen is in the bone? |
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Definition
|
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Term
| whatcallogen types in dentin and cementum? |
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Definition
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|
Term
| What protein is in enamel |
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Definition
|
|
Term
| What protein is in dentin |
|
Definition
| Dentin sialophosphoprotein DSPP |
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Term
|
Definition
| Mutations in amelogenin gene which plays role in enamel formation during development.Causes enamel is abnormally thing. Yellow and brown. Enamel is easily damaged and sensitive to temp |
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Term
|
Definition
| Patients have mutations in collagen I and affects dentin mineralization. Bones are worse. |
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Term
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Definition
| It is the most common dentin inherited disease (1:8000) patients have mutations in non-collagen protein dentin sialophosprotein. Causes abnormal dentin matrix mineralization and discoloration |
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|
Term
| ECM is subject to turnover |
|
Definition
| Not only synthesized but degraded in a controlled fashion. By matrix metallproteases. |
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|
Term
| What protease is responsible for enamel turnover? |
|
Definition
| enamelysin is important for proteolytic processing of extracellular matrix proteins. |
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|
Term
| What does excessive MMP activity lead to? |
|
Definition
| Collagen breakdown of gingiv and bone destruction in periodontitis. Treated by periostat. Doxycylcine inhibits MMP activity |
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|
Term
| Excessive MMP activity in articular cartilidge caueses |
|
Definition
| Osteoarthritis. Excessive degradation of collagen II and PROTEOGLYCANS such as aggrecan by excessive MMP. |
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Term
| Extracellular matrix proteins are associated with |
|
Definition
|
|
Term
| Classes of molecules in ECM? |
|
Definition
| Fibrous proteins (colognes) 2. Polysaccharide chains 3. Proteins with glycosaminoglycans 4. Inorganic crystals. |
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Term
| What is a fibrous protein and most abundant in animal tissues? |
|
Definition
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|
Term
| Collagen are made up of what type of sequence? |
|
Definition
| Alpha chains mostly glycine. |
|
|
Term
| whatisthe difference between alpha helix and alpha chain? |
|
Definition
| 3 alpha chains are twisted together into a right handed super helix |
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|
Term
| What disease is caused by glycine mutations? |
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Definition
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