Term
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Definition
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Term
| brain recieves _% of CO an d-% of O2 |
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Definition
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Term
| *brain has little glycogen |
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Definition
|
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Term
| *flow to brain is autoregulated, what is |
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Definition
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Term
| *blood flow to brain is 50ml/min |
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Definition
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Term
hypoxia of BP < _ can stimulate blood flow to brain-
problem is _ causes loss of conciousness |
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Definition
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Term
|
Definition
| impaired blood flow to brain |
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Term
2 mian forms of stroke-
which is more common
whihc more severe |
|
Definition
hemorrhage
ischemia
ischemic
hemorrhagic |
|
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Term
| *risk factors for stroke overlap with cardiovasc disease like age, smoking, diabetes, htn |
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Definition
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Term
| stroke is _ leading cause of death |
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Definition
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Term
| in the US, strokes overlap with |
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Definition
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Term
| cardiac arrest= _ ischemia to brain |
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Definition
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|
Term
| stroke is _ ischemia to brain |
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Definition
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Term
| hemorrhagic can occur in what 2 placces |
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Definition
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Term
what test is good to diff hemorr and ischm
which appears earlier? |
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Definition
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|
Term
| 3 hemorrhages causes by tramua |
|
Definition
epidural
subduralsubarachnoid |
|
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Term
| most common cause of non tramutic hemorrhagic strokre- |
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Definition
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|
Term
| increases _ causes water influx in hemorrhagic stroke |
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Definition
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|
Term
| increased _ can collapse vessles in hemorr stroke |
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Definition
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Term
| what causes oxidative damamge in hemorr stroke |
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Definition
Fe (normal protection from O2 stress not present in this brain part)
(brain may be discolored for yrs) |
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|
Term
parenchymal hemorrhages are most often due to?
what parts of rain most often hit-3 |
|
Definition
HTN
basal ganglia, thalmus, pons |
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Term
| brain is supplies by what artiereis-2 |
|
Definition
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|
Term
| the arteris that supply the brain converge at the _ |
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Definition
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|
Term
what 2 arteries in the brain coem fromt he carotid?
which one comes from the basilar? |
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Definition
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|
Term
which artery supplies 80% of blood to hemispheres?
why is this important? |
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Definition
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|
Term
| characterisitcs of emboli in ACA |
|
Definition
| paresis loss contralateral in leg and foot |
|
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Term
|
Definition
| aphasia, unilateral motor dysfunction |
|
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Term
|
Definition
| visual distb, memory dysfnct |
|
|
Term
| basilary artery occulsion can cause occulomotor and balance problems |
|
Definition
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|
Term
| vertebral artey occulsion can produce effects like basilar artery |
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Definition
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Term
| major risk factor for thrombus is- |
|
Definition
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|
Term
chronic HTN causes waht to degenerate
-when the tissue around degnerates its called |
|
Definition
small vessesl deep in brain
lacunar infarcts |
|
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Term
| what are the prinicpal fidning of soeone with vascular demementia |
|
Definition
|
|
Term
| stroke is deficit that last sfor how long |
|
Definition
|
|
Term
| transient ischemic attack is deficit that- |
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Definition
|
|
Term
| 2 types of cell death in vessel occlusion for stroke- |
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Definition
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|
Term
| hich cell death occurs at the core |
|
Definition
|
|
Term
| which cell death has cell swelling and lysis |
|
Definition
|
|
Term
| which cell death invovles pro inflamm cytokines-> reactive oxygen species |
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Definition
|
|
Term
| after few days f the aute inflamm response of necrotic death it shofts to- |
|
Definition
| repair/anti infalmm molcecules |
|
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Term
| whihc cell death results in glial scar |
|
Definition
|
|
Term
| whcih cell death occurs in the penumbra |
|
Definition
|
|
Term
| *in apoptptisis cell death not all the cells in the area died and resume nromal funct, this si whn desicon is to program cell death or fix it |
|
Definition
|
|
Term
| main advtg of apoptoic cell death is- |
|
Definition
| no inflamm or collateral damage |
|
|
Term
| the most impt determingin factro if a cell lives or dies in the penumbra is- |
|
Definition
| excititoxicity/ excess glutamate in extra cell |
|
|
Term
| * in ischemia cell depolarize and rlease Glu, and astrocytes are impaired to be abel to uptake it |
|
Definition
|
|
Term
| Glu release in ischemia is followed by what electroyltes- |
|
Definition
|
|
Term
| the problme with too muhc Glu is- |
|
Definition
| activate NMDA-> Ca influx->apoptosis |
|
|
Term
| NMDA recpotr anatgs dont affect the core death, but can reduce size of infacrt thru penumbra* |
|
Definition
|
|
Term
| what 3 misc tx can reduce infarct size |
|
Definition
cannbinoids
adenosene
hypothermia |
|
|
Term
|
Definition
|
|
Term
| plastiicty can be inhibited by what-3 |
|
Definition
| glial scars and meylin and inflamm |
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