Term
| another name for headache |
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Definition
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Term
| pain in the head shares features with what kind of pain? |
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Definition
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Term
| pain in the head is mediated by what receptors? |
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Definition
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Term
| nocicptors can be activated by what 3 things? |
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Definition
| chemical, temp, mechanical |
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Term
| what can make a hyperalgesic state in the brain? |
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Definition
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Term
| endogenous alterations of neuronal funct is called? |
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Definition
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Term
| other parts of the head with somatic nociceptors-2 |
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Definition
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Term
| these structures of the brain can produce pain-4 |
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Definition
| dura matter, cerebri, dural sinuses,proximal pial arteries (ie middle meninigeal artery) |
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Term
| structurs of the brain that cant cause pain-4 |
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Definition
| ependymal of ventricles, choroid plexus, pial veins, brain parenchyma |
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Term
| intracranial nerve stimuli comes from what nerve? |
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Definition
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Term
| trigeminal pain is referred to _ portions of the head |
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Definition
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Term
| posterior regions pain (occipital) is form what nerves?-3 |
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Definition
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Term
| nocicpetors synpase on 2nd order neurons in the _ of the brainstem |
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Definition
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Term
| the 2nd order neurons then ascend where: |
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Definition
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Term
| 3rd order neurons in thalmus send axons to where |
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Definition
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Term
| descnding _ pathways can regulate the neurons in the TCC |
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Definition
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Term
| what provides the descending inhibiton for pain modulatin?-3 |
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Definition
5HT (Raphe)
periaquadatl duct (PAG)
NE (locus correlus) |
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Term
| where do autonomic symptoms from headaches come from? -2 |
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Definition
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Term
| what are the headache autonomic symtpoms?-4 |
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Definition
tearing
nasal congestion
nasuea
vomiting |
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Term
irritaiton of _ creates pain
what is the other name for this? |
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Definition
meninigeal structures
vasospasm |
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Term
| migraine a vascular or brain disorder? |
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Definition
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Term
trigeminal nerves release _ coumpunds at brain vessels
-three examples? |
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Definition
inflammaotry
prostoglandins, CGRP, NO |
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Term
| what is the reason for continued pain even tho meningeal irrtaiton is gone |
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Definition
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Term
| CGRP is shown to be invovled in migraines why? |
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Definition
| bc CGRP antagonists are shown to be effective against them |
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Term
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Definition
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Term
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Definition
| results from antoher underlying medical conditoins |
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Term
| what is the thrid category of headache? |
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Definition
| cranial neurlagia and facial pain |
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Term
| cranial neuralgias and central face pain can be caused by-4 |
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Definition
cranial nerve damage
herpes
ocular diabetic neuropathy
cold stimulus |
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Term
| secondary headaches can be due to-6 |
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Definition
head tramua
vascualr disorder (ie thrombus)
substance withdrawl
infeciton
disorder of eeys/teeth
altered homeostasis |
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Term
| what are the 4 categories of primary headache |
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Definition
migraine
tension type
cluster/tirgeminal autonomic
other (stabbing, cough, sex related)`` |
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Term
| what are the characteristics about a migraine |
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Definition
pulsing
unilateral
pulsating |
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Term
| how long cna migraines last |
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Definition
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Term
what is most common headche?
second most |
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Definition
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Term
| which is more common and sidabling, auro or no auroa migraine |
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Definition
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Term
| can you expereince na aurora without a headache? |
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Definition
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Term
| what is the premonitory period? |
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Definition
| 2 dayas pre migraine with depression, craving, and altered activity |
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Term
a migraine can be followed by a _ phase
what is it? |
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Definition
resolution
-person feel either euphoric or depressed |
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Term
| what are some triggers fro a migraine?-5 |
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Definition
| bright light, hunger, lack of sleep, alcohol, caffeine |
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Term
| one hypothesis for migraine is that it is a _ disorder |
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Definition
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Term
| one hypothesis of migraine is that vasospasms in an artery result in-3 |
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Definition
brief ischemic artery
stretch receptor acitvatingpulsating blood stretchingt he vessle->pain |
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Term
| one genetic risk factor for migraines is a polymorphism in- |
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Definition
| EAAT2 (glu uptake transporter) |
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Term
| the familial hemiplegic migraine is where the person feels- |
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Definition
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Term
| what are the 3 genes in FMH (famil hemi migraine) |
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Definition
CACNa1a (P/Q Ca channel)
ATP1a2 (Na/K atpase
SCN1a (volt gate Na channel) |
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Term
which gene for familial hemi migraine is most common?
which activates, leading to hyperexicting GABAinterneurons? |
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Definition
CACN
SCN1 (the hyperxcite->cortical spreding depression) |
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Term
cortical spreading depression a loacilized _ occurs
behind this the neurons are_ hence the name |
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Definition
depression
silent spreading |
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Term
| when does cortical spreading depression occur? |
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Definition
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Term
| * movement of the visual field during aurura matches hte abnormla eletrical activty across the occiptla cortex |
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Definition
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Term
| *CSD has been proven to disrupt arterial function of vessels feeding noccieptors |
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Definition
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Term
| what is the % prevelance of tension type headaches |
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Definition
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Term
| characteristics of tension type headaches-3 |
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Definition
bilateral
non pulsating
bandlike discomfort (pressing) |
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Term
infrequet tension headches
frequent
chronic |
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Definition
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Term
cluster headaches are characterized by -
examples |
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Definition
autonomic sysmtpoms
tearing, runny nose |
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Term
| which hedache type are ppl given decongestant which doenst work |
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Definition
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Term
| characteristics of cluster hedaches-4 |
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Definition
sever pain
unilateral
attaks cluster
hyperactive/pacing |
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Term
| whcih type of headache to the headches go into remission for wks-yrs |
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Definition
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Term
| cluster has more men or woemn |
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Definition
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Term
| a sporadic genetic association has been shown to relate to cluster headaches- what is it? |
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Definition
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Term
| the pathophys of cluster headacehs involves the activaiton of what system? |
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Definition
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Term
| what activaiotn explains the phasic cyclicng of cluster headaches |
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Definition
| posterior hypothalmus/circadian rythm/sleep cycle |
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