Term
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Definition
| {(%neutrophila +%bands) xWBX]/100 |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| the degree of neutropenia shows your- |
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Definition
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Term
| chemo induced neutropenia depdns on what factors?-4 |
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Definition
type of chemoc
pretreatment
presence of cancer in bone marrow
age |
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Term
| what is the most common DOSE LIMITNG tox of chemo? |
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Definition
| neutropenia/infection (morbidity and mortality) |
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Term
most chemo cause nadir btwn days-
recovery by day |
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Definition
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Term
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Definition
| there is lowest amnt of neutrophils |
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Term
| consequuences of neutropenia is increased-3 |
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Definition
| infx, ANX, hospitlization |
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Term
| conseq. of neutropenia is compromised- |
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Definition
| tx effiacy due to dose decreases |
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Term
| to prevent neutropeniawhat two things cna be done |
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Definition
dose reeduction
hematooeotic growth factors (CSF) |
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Term
| For tx of neutropenia, what 3 things are done |
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Definition
hospitlization
ABX if febrile
hematopeotic growth factors |
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Term
| the G-CSF (gnulocytte stim factor) is 3 things-3 |
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Definition
glycoportine
growth factor
cytokine |
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Term
| G-CSF is normally produce by? |
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Definition
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Term
| G-CSF recpt is on bone marrow, if stimualted what can it do-2 |
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Definition
proliferation of granulocuytes
bone marrow cell rlease |
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Term
| G-CSF signal pathway invovles what molcules-3 |
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Definition
JACK/STAT
RAS/MAPK
PI3K/Protein kinase B (Akt) |
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Term
| _ G CSF stimulates rpoduction of neutrophuls |
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Definition
| filgrastim (and pegylates form pregrilgrastim) |
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Term
| _ G cSF stimulates myelopoeisis |
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Definition
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Term
|
Definition
psot chemo febrile nuetropenia
post inducer of hematopeotic stem cells for stem cell trnasplantation |
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Term
| G CSf is used for chemo febril enutropenia when-3 |
|
Definition
risk is 20% and no other regimen
doesnt compromise dose intensity
reduces dose delya |
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Term
| G CSF is sued in primary prophylaxis when- |
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Definition
| POSt -CT before neutropenia |
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Term
| G CSF is used as secdonary prophylaxis when- |
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Definition
| post CT pt with previeoius neutropenia from CT |
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Term
Use primary prohpylaxis G CSF when:
CT and risk of FN >20% |
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Definition
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Term
Use primary prohpylaxis G CSF when:
CT and risk of FN 10-20% |
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Definition
| use if other risk factors (age, hx, etc) |
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Term
Use primary prohpylaxis G CSF when:
CT and risk of FN <10% |
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Definition
| Never (only if complications start) |
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Term
| when is C-CSF agents used after chemo? |
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Definition
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Term
filgrastim is dosed how mnay times per day and howmnay days?
how long does a dose last? |
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Definition
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|
Term
filgrastim is for inpt/outpt
which med is for the other? |
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Definition
inpatient
pegylated is for outpat |
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Term
| Pegylated filgrastim is dosed how much? |
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Definition
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Term
| Sargromostim us used when? |
|
Definition
| after BM tnrasplant if pt has fungal infx |
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Term
|
Definition
post chemo as primary prevetnion of FN
chronic neutropenia
stem cell trnaspl
pierpiheral mobilization |
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|
Term
| sargamostim is only indicated in pediatrics/adults after _ indcution therapy |
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Definition
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Term
Filgrastim dosing
how admin?
max if <132 lbs, if >? |
|
Definition
5 mcg/kg per day
SQ
300, 480 |
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Term
Dosing pegfilgrastim
admin? |
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Definition
|
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Term
| whcih G CSf has longest half life |
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Definition
|
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Term
dosing of Sargramostim
admin? |
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Definition
|
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Term
|
Definition
sickel cell
anaphylaxis
resp
splenic rupture |
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Term
| Chemo Tx with high risk for nuetropenia:-6 |
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Definition
(Non- Hgokins CHOP, ICe, RICE)
cyclophosphamide, etoposide, cisplatin, paclitexal +cisplatin,
topotecan
Taxane +dox +/- cyclpphos |
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|
Term
clincial pearls about G CSFs-
are admin _ chemo
no change in infx/overall omrtality w/?
which is better? |
|
Definition
24 hrs post
treat,ent
prevention! |
|
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Term
| what is proimary issue with G CSFs? |
|
Definition
|
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Term
|
Definition
| esophagus, duodenum, ileum, colon, rectum, stomach |
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Term
|
Definition
| infalmm of mucus surfaces in body |
|
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Term
| what disease invovles red ulcerative sores? |
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Definition
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|
Term
| oral mucosisits manifests as-3 |
|
Definition
| erythemia, ulcers, hemorrhage |
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|
Term
mucosisits is damage to_ of what places
why? |
|
Definition
epitheloum
GI, oralpharyngeal
chemo affects the rapid dividing cells of muscus |
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Term
|
Definition
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Term
|
Definition
| signaling with messengers |
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Term
|
Definition
| amplificaiton of apopotosis/bacterium invades |
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Term
|
Definition
| fungus invades/ulceration |
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Term
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Definition
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Term
| oral mucosists is most common* *also more aggreive in this one |
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Definition
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Term
| *can get nasal and vaginal mucosistis |
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Definition
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Term
Grade _ mucosists:
painless ulcers, mild soreness |
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Definition
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Term
Grade _ mucosists:
painrful esema or ulvers but eating possible |
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Definition
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Term
Grade _ mucosists:
painful edema/ulcers, require IV eating |
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Definition
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Term
Grade _ mucosists:
severe ulcers requiring TPN or intubaiton for feeds |
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Definition
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Term
|
Definition
pain
diff eating
adb pain
diarrhea |
|
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Term
| complicaitons of mucosistis-3 |
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Definition
bactermia/sepsis
poor nutrition
decrease activty/QOL |
|
|
Term
| what class of agnets are used to tx mucosistis |
|
Definition
| keratinocyte growth factor (KGF) |
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Term
|
Definition
decrease DNA damage
increase detox enzyme to protect from ROS
decrease pro inflamm cytokines
decrease apoptosis |
|
|
Term
KGF doesnt have evidence for use in what-2
why? |
|
Definition
chemo only regimens
solid tumors
may increase tumor growth |
|
|
Term
| KGF jas indicaitons for us in-3 |
|
Definition
hametologic malignancy
high dose chemo + total body irridation
stem cell trnasplant |
|
|
Term
| Palifermin (Kepivance) is- |
|
Definition
|
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Term
|
Definition
60 mcg/kg/day x 3 day before
and smae x 3 days after |
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Term
|
Definition
|
|
Term
| plaifermin shoundlnt be admin _ chemo |
|
Definition
| 24 hrs before, during, or after meyelotoxic |
|
|
Term
| palifermin is contradinciated ni what person |
|
Definition
| allergic to E. coli protein |
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Term
|
Definition
thick tongue/discolor
taste disturbance
amylase/lipase elevation |
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