Term
| What the most common ABO type? |
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Definition
| 45% O (whites) 49% O (blacks) |
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Term
| What is the most common Rh antigen? |
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Definition
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Term
| What genotypes make up A1 phenotype? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Age of patient as a practical consideration for transfusion |
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Definition
| Newborns always get O cells AB plasma because antigens not developed yet, |
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Term
|
Definition
| O, because no antigens on cells |
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Term
|
Definition
| AB patients, because they have no antibodies in their plasma |
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Term
|
Definition
| AB plasma, because no antibodies in the plasma |
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Term
| Universal Plasma receiver |
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Definition
| O patients, because no antigens on their cells |
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Term
| Perfect match transfusion |
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Definition
| A pos patient get A pos blood |
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Term
| ABO compatible transfusions |
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Definition
patient get product which is compatible but not perfect match
A pos patient gets O positive |
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Term
| When are ABO incompatible transfusions considered? |
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Definition
| when you run out of compatible product |
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Term
|
Definition
| cellular and plasma, need to consider antigens and antibodies |
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Term
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Definition
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Term
|
Definition
| D+ for transfusion purposes |
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Term
| Rh negative patient with Rh positive cells? |
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Definition
| male, or female out of child baring age (+50) |
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Term
|
Definition
| need to consider what you will need for the rest of the day |
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Term
| How long until platelets outdate? |
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Definition
|
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Term
| What plasma do you need for a trauma? |
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Definition
|
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Term
| What are the regulatory agencies involved in Blood Banking? |
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Definition
|
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Term
|
Definition
| blood is a drug, blood banks modify drug, need to licensed if you ship product |
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Term
|
Definition
| regulate BB labs by using standards, monitor best practices |
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Term
|
Definition
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Term
| Other agencies involved in BB |
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Definition
| joint commission, OSHA, CMS |
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Term
|
Definition
| Anti-Ig reagent +/- complement reagent |
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Term
|
Definition
patient plasma + LISS + reagent red cells
Testing for antibodies in patient plasma, AHG binds antibody that bound to red cells = agglutination |
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Term
|
Definition
| patient cells (already have IgG) + AHG to agglutinate = auto antibody in patient |
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Term
|
Definition
| control for negative tests, react and bind to AHG to create agglutination, confirms true negative |
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Term
| factors that influence tests |
|
Definition
| washing steps, technique, reagents, temp |
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Term
|
Definition
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Term
|
Definition
| Antibody screens. IDs and Xm |
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Term
|
Definition
| transfusion reaction investigations (alloantibody) |
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Term
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Definition
| On all red cells except with bombay phenotype, H antigen is precursor to A and B antigens, amount of H depends on ABO type |
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Term
|
Definition
| GalNac=GALactosainyl transferase adds N-ACetyl-galactosamine |
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Term
| H antigen is highly expressed on O cells |
|
Definition
| because they have no A or B antigens |
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Term
|
Definition
| Rare, Autosomal Recessive phenotype characterized by the absence of H, A and B antigens |
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Term
|
Definition
| O positive, reacts with every cell |
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Term
| Rh antibodies sensitization |
|
Definition
| can only occur through pregnancy, IgG |
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Term
|
Definition
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Term
|
Definition
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Term
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Definition
| IgG coated red cells- react with anti-IG reagent |
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Term
|
Definition
| derived from one clone of plasma cells |
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Term
| Which of the following is a clinically significant antibody whose detection has been reported in some instances to be dependent on anticomplement activity in polyspecific AHG? |
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Definition
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Term
| False-positive DAT results are most often associated with: |
|
Definition
| use of refrigerated, clotted blood samples in which complement components coat RBCs in vitro |
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|
Term
| Polyethylene glycol enhances antigen-antibody reactions by |
|
Definition
| concentrating antibody by removing water |
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Term
| solid-phase antibody screening is based on |
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Definition
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Term
| Which factor can affect AHG testing, yet it controllable in the lab? |
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Definition
|
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Term
|
Definition
| cross-links sensitized cells, resulting in visable agglutination |
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Term
|
Definition
| causes agglutination by adjusting zeta potential between RBCs |
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Term
|
Definition
| - low ionic strength environment causes RBCs to take up antibody more rapidly |
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Term
|
Definition
| increses test sensitivity, aggregates RBCs causing closer proximity of RBCs to one another, assisting in antibody cross-linking |
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Term
|
Definition
| - Reduce RBC surface charge, destroys or depresses some RBC antigens, enhances other RBC antigens |
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