Term
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Definition
| process by which mature blood cells develop from precursor cells |
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Term
| vascular sinuses of bone marrow of certain bones esp. flat bones of skull, ribs, sternum, vertebrae, pelvis and some long bones |
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Definition
| location of hematopoiesis in adult humans |
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Definition
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Term
| blood islands in yolk sac |
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Definition
| where hematopoiesis occurs in fetus 1st (during first trimester) |
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Term
| liver and lymphatic tissue |
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Definition
| where hematopoeisis occurs in second trimester of fetus |
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Term
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Definition
| where hematopoeisis occurs in last month of pregnancy |
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Term
| restricted primarily to marrow cavities |
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Definition
| where hematopoeisis occurs at birth |
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Term
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Definition
| what happens to number of active hematopoeisis sites with age |
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Term
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Definition
| type of marrow that is active, contains large number of RBC's |
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Term
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Definition
| inactive bone marrow, more in adults |
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Term
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Definition
| specialized CT in fluid extracellular matrix (plasma) |
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Term
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Definition
primary vehicle for transport of nutrients, O2, CO2, waste products, and hormones
also functions in thermo regulation and homeostasis |
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Term
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Definition
| average volume of blood in adults |
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Term
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Definition
| liquid, extracellular matrix, ~55% of blood volume |
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Term
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Definition
| percentages of contents of blood(plasma?) ____% water, ____% electrolytes(Na, Ca, K, HCO3), ____% protein |
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Term
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Definition
| plasma without clotting factors |
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Term
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Definition
| albumin, globulins, fibrinogens |
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Term
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Definition
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Term
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Definition
| location of albumin synthesis |
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Term
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Definition
| function as transport protein for insoluble metabolites (ex: fatty acids) |
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Term
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Definition
| responsible for maintaining colloid osmotic pressure in blood vessels |
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Term
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Definition
| large molecules, used as transport proteins for lipids and heavy metal ions |
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Term
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Definition
| largest fraction of globulins, aka antibodies |
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Term
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Definition
| location of antibody/immunoglobulin synthesis |
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Term
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Definition
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Term
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Definition
| polymer of fibrinogen that forms during clotting |
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Term
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Definition
| location of fibrinogen synthesis |
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Term
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Definition
| cleaved to thrombin to catalyze fibrinogen to become fibrin |
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Term
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Definition
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Term
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Definition
| where formed elements are made via hematopoeisis |
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Term
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Definition
| volume of RBC's ___% in males, ____% in females |
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Term
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Definition
| same as hematocrit (+/- buffy coat depending on source) |
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Term
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Definition
| WBC's and platelets (1-2%) |
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Term
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Definition
| drop of blood smeared, air dried, stained with modified Romanovsky method (ex: Wright Giemsa) |
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Term
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Definition
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Term
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Definition
| diameter of a RBC, used as a reference to measure other things |
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Term
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Definition
| shape of RBC's that allows deformability and resiliency, also increase surface area for gas exchange |
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Term
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Definition
| primary structural protein in RBC's |
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Term
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Definition
| binds to inner surface of RBS plasma membrane |
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Term
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Definition
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Term
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Definition
| iron containing pigment involved in O2 and CO2 transport in RBC's |
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Term
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Definition
| Hemoglobin has __ # polypeptide chains with __ # Fe containing heme groups |
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Term
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Definition
| number of Hb molecules which transport O2 in RBC's |
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Term
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Definition
| results from decreased iron or blood loss |
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Term
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Definition
| disease resulting from a single AA substitution (Valine for Glutamic Acid) causing change in structure of Hb molecule |
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Term
| position 6 of beta globulin chain |
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Definition
| where AA is substituted in sickle cell anemia |
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Term
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Definition
| causes damage to endothelial cells of capillary walls due to rough edges, more fragile, easily damaged |
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Term
| enucleated & organelles degenerate |
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Definition
| what happens to RBC's b4 they are released into blood stream |
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Term
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Definition
| occasional basophillic nuclear remnants visible within cytoplasm of RBC's |
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Term
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Definition
| immature RBC's with stippled cytoplasm, still have some rRNA. Slightly larger than mature RBC's |
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Term
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Definition
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Term
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Definition
| trends in RBC production cell size ___, loss of nucleus and organelles, ____ in Hb |
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Term
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Definition
| increased number of reticulocytes in circulation associated with chronic blood loss, or hemlytic anemia (left shift) |
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Term
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Definition
| on a scale of RBC maturity with most mature to the right and least mature to the left, what happens with chronic blood loss/hemolytic anemia |
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Term
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Definition
| with iron deficient anemia, RBC's are small ( _____) and pale staining (_______) |
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Term
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Definition
| outer cell membrane with cytoplasm, Hb, and a few enzymes. No mitochondria |
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Term
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Definition
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Term
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Definition
| the only way RBC's can make energy |
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Term
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Definition
| remove senescent(old) RBC's from circulation |
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Term
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Definition
| another name for platelets |
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Term
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Definition
| small non-nucleated cells containing few organelles |
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Term
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Definition
| large polyploid cells in bone marrow with single multi-lobed nucleus |
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Term
| megakaryocytes in bone marrow |
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Definition
| where/what platelets come from |
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Term
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Definition
| pleated areas in the cytoplasm of megakaryocytes where platelets tear off. |
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Term
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Definition
| lifespan of human platelets |
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Term
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Definition
| function in blood clotting, form physical plugs at the site of vascular damage |
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Term
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Definition
result of cascade interaction between plasma proteins and coagulation factors
occurs only if endothelial lining of vessel is injured |
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Term
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Definition
| faster pathway of coagulation |
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Term
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Definition
| slower pathway of coagulation because it requires numerous clotting factors (von Willebrand's, factor VIII) and longer cascade reaction |
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Term
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Definition
| initiated by release of tissue thromboplastin as a result of tissue damage |
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Term
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Definition
| initiated by exposure of collagen |
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Term
| Factor 12 -> factor 11 -> factor 9 -> (with help of factor 8) |
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Definition
| intrinsic pathway of coagulation cascade to factor X |
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Term
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Definition
| extrinsic pathway of coagulation cascade to factor X |
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Term
| 10-> 5 -> 2 (prothrombin to thrombin) -> 1 (fibrinogen) |
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Definition
| coagulation cascadde from factor X onward |
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Term
| when wall of blood vessel breaks, tissue injury results |
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Definition
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Term
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Definition
| what platelets mechanically adhere to |
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Term
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Definition
| potent vasoconstrictor-constricts sm muscle in damaged vessel to minimize blood loss |
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Term
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Definition
| point where factor X is activated in coagulation cascade |
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Term
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Definition
| results in conversion of prothrombin to thrombin, which converts soluble fibrinogen to insoluble fibrin |
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Term
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Definition
| results in conversion of prothrombin to thrombin, which converts soluble fibrinogen to insoluble fibrin |
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Term
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Definition
| net that forms and traps platelets and RBC's |
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Term
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Definition
| exhaustion of fibrinogen and removal of thrombin from blood during conversion of fibrinogen to fibrin |
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Term
| antithrombin 3 and heparin |
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Definition
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Term
| heart attack, stroke, disseminated intervascular coagulation (DIC) |
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Definition
| result of inappropriate clot formation |
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Term
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Definition
| deficiency of clotting factors, so blood can't clot |
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Term
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Definition
| hemphilia is due to a defect in (intrinsic or extrinsic) pathway |
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Term
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Definition
| deficiency in clotting factor 8 |
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Term
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Definition
| deficiency in clotting factor 9 |
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Term
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Definition
| deficiency in clotting factor 11 |
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Term
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Definition
| deficiency in von willebrand's clotting factor |
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