Term
| Why are prostagladins named so? |
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Definition
| They were discovered by isolatinng human semen. Thinking they had come from the prostate gland, he named them prostaglandins. However, they are synthesized in every cell of the body. |
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Term
| How do prostaglandins function? |
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Definition
| Are like hormones in that they act as a chemical messenger, but do not move to other sites, but work right within the cells where they are synthesized. |
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Term
| What is the structure of prostaglandins? |
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Definition
| Unsaturated carboxylic acids, consisting of a 20 carbon skeleton that also contains a five member ring. Are biochemially synthesized from fatty acid, acrachidodnic acid. |
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Term
| What are the 4 possible prostaglandins? |
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Definition
| PGI2, PGE2, PGF2 alphs, TXA2 |
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Term
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Definition
| antiplatelet aggregation, vasodilation |
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Term
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Definition
| smooth muscle relaxation, vasodilation |
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Term
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Definition
| smooth muscle contraction, vasoconstriction |
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Term
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Definition
| platelet aggregation vasoconstriction |
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Term
| What function do leukotrienes perform? |
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Definition
| Responsible for the symptoms of asthma: Inflammation, Bronchoconstriction, Vasoconstriction. |
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Term
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Definition
| medicationi used to soften and thin the cervix. may be used if past due date, or havve a large baby near or past due date. |
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Term
| What does Prostaglandin E1 do? |
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Definition
| Prostaglandin is strong vasodilation, significant beneficial effects ovver placebo on ulcer healiing and pain relief. May be beneficial for patients with erectile dysfunction. |
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Term
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Definition
| prinncipal mediator of inflammation in rheumatoid arthirtis and ostoarthritis. Nonsteroidal Anti-Inflammatory Medications and selective cyclooxygenase-2 inhibitors reduce Prostaglandin E2 production. |
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Term
| What enzymes transform arachidonic acid into Prostaglandin E2? |
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Definition
| Cyclooxygenase enzymes and terminal prostaglandin E synthases (PGES) |
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Term
| What molecules promote tumor growth and metastasis through stimulation of cell proliferation, invasion, and angiongenesis? |
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Definition
| COX2-derived bioactive lipids, and Prostaglandin E2 |
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Term
| How do prostaglandins affect females? |
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Definition
| They have an impact on ovarian, uterine, placental, and pituitary function to regulate reproduction. |
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Term
| What roles in pregnancy do prostaglandins play? |
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Definition
| Important roles in ovulation, luteal function, implantation, maintenance of gestation, microbial-induced abortion, parturition, postpartum uterine and ovarian infections. |
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Term
| What medications are a prostaglandin inhibitor? |
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Definition
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Term
| What enzymes do NSAIDs target and what is the overall effect? |
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Definition
| cyclooxygenase enzymes (COX). Decrease incidence of malignancies, including colorectal, esophageal, breast, lung, and bladder cancers. |
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Term
| What enzyme does NSAID specifically inhibit? |
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Definition
| Cycloxygenase activity of PGH2. Inhibit formation of prosatglandins involved in fever, pain, and inflammation. Inhibit blood clotting by blocking thromboxane formation in blood platelets. |
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Term
| How do ibuprofens act specfically? |
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Definition
| By blocking hydrophobic channel by which arachidonate enter the cyclooxygenatse active site. |
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Term
| Where is the thymus located? |
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Definition
| In the upper anterior portion of the chest cavity just behind the sternum. |
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Term
| What do the hormones of the thymus do? |
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Definition
| Stimulate the production of infection-fighting cells. Central importance inn maturationn of T cells. |
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Term
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Definition
| Allows lymphocyte precursors from the bone-marrow to become thymocytes and mature into T cells. |
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Term
| What consequences will be seen from losing the thymus at an early age? |
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Definition
| Sever immunodeficiency and a high susceptibililty to infection. Ability of T cells to recognize foreign antigens is mediated by the T cell receptor. |
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