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| function of endocrine system |
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controls internal environment responds to chance copes with stress regulates growth and development regulates phases of reproduction |
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| chemical messenger secreted into blood stream to reach cells |
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| ductless gland that secrets a hormone |
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| gland that secretes into a duct |
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| glycoprotein molecules that bind to hormone |
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there is a lack of hormones receptor proteins are produced cell becomes more sensitive |
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excess of hormones causes receptors to decrease decreases cell sensitivity |
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| steroids, biogenic amines, peptides/proteins, eicosanoids |
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type of hormone lipid derived from cholesterol made in smooth ER testosterone, estrogen, progesterone |
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simplest hormone modified amino acids thyroid, epinephrine, histamine, serotonin |
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hormone composed of 3-200AA made in rough ER glycoproteins like oxytocin, insulin, thyroid stimulating |
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hormones lipid derived from 20 carbon fatty acid prostaglandins-tissue inflammation and repair |
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| lipid soluble and water soluble |
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| lipid soluble hormone mechanism |
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diffuses into cell from blood binds to receptors in cell changes gene expression new protein alters cell activity |
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peptide and protein hormones hormone (first messenger) delivers message to receptor receptor stimulates enzyme that converts ATP to cAMP cAMP (second messenger) stimulates activity cAMP is deactivated after period of time |
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| hypothalamus, pituitary, pineal, thymus, thyroid, parathyroid, adrenal, pancreas and gonads |
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next to pituitary gland in brain link between nervous system and endocrine makes hormones that regulate other glands and autonomic system |
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makes hormones that act on other endocrine glands follicle stimulating hormone (weird names) makes hormones that act directly (prolactin, growth) |
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directly connected to hypothalamus doesnt produce hormones stores and releases hypothalamus hormones |
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in brain that regulates biorhythyms melatonin-connected to high insulin, typeII diabetes, and prostate/breast cancer |
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butterfly shaped gland in throat secretes thymo- hormones |
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| thyroid hormone and calcitoning (deposits calcium in bones) |
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| 4-8 glands in the back of the thyroid |
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produces corticosteroids mineral corticoids, glucocorticoids, gonadocorticoids |
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produced in adrenal cortex controls concentration of minerals in blood |
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produced in adrenal cortex regulates metabolism and resistance to stress mostly cortisol |
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produced in adrenal cortex androgens-male sex hormone |
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part of sympathetic nervous system epeinephrine, norepinephrine |
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long organ glucagon-causes liver to release glucose insulin-inhibits release of glucose |
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produces egg and sperm secondary sexual characteristics |
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| erythrocytes, leukocytes, platelets, plasma |
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non nucleated, lack mitochondria use anaerobic metabolism contributes to blood viscosity functions to transport O2 and CO2 |
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hemoglobin is protein-iron complex four heme groups that contain one iron molecule iron(heme) binds to one O2 each erythrocyte has 250 million hemoglobin molecules 20% CO2 transported by binding to globin |
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lifetime 100-120 days cant synthesize new proteins becomes rigid, degenerates, and recycled by macrophages in spleen |
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fewer than RBC nucleated with organelles use diapedesis-amoebic movement chemotaxis-movement based on chemicals granulocytes and agranulocytes |
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| neutrophils, eosinophils, basophils |
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granulocyte 50% of WBC 2x larger as RBC 3-6 lobes granules contain hydrolytic enzymes ingest bacteria and fungi with antibiotic proteins |
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1-4% of WBC nucleus resembles old telephone receiver kills parasites and worms phagocytizes foreign proteins |
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.5% of WBC smaller than neutrophil histamine containing granules that dilate blood vessels and attracts other WBC's |
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agranulocyte 3-8% of WBC oval nucleus fixed or wandering, first responder to take apart trash |
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agranulocytes 20-25% of WBC immediate immune response T-attach viruses cancer cells, transplants B-develop into plasma antibiodies |
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large membrane bounded cell fragments formed in red blood marrow 2k-3k pieces lack nucleus clotting response |
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55% of blood 91% water, 1.5% solutes, 7% proteins |
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substance that triggers immune response antibodies attack antigens |
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| protein that attacks specific antigens |
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| antigen/antibody reaction |
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antigens become agglutinated and destroye no O2 carry, blocks veins and arteries |
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| space containing the heart |
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| blood flow from right side of the heart to lungs and back to body |
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| from the body to the right side to the lungs |
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self exciting can be modified by nervous and endocrine system coordinate heart contraction |
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| autorhythmic characteristics |
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plasma membrane connected at intercalated disks connected at desmosomes. prevents cells from separating gap junctions, large mitochondria (25% of cell volume), fewer T Tubles, wider |
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| resting potential of heart |
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fibers brought to threshold by neighboring fibers voltage gated fast Na+ gates open for fast depolarization |
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AP generated by sinoatrial node travels down conduction system |
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voltage gated slow Ca+ channels open in cell membrane and SR starts system of muscle contraction K+ opens and leaves the cell balancing Ca+ inflow (250ms) |
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voltage gated K+ open and rapidly exits Ca+ closes restores membrane potential |
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| longer than skeletal, longer than contraction |
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| autonomic control of heart rate |
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medulla oblongata cerebral cortex, hypothalamus sensory receptors (chemo and baro) |
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R atrium goes to R ventricle and L atrium through foramen ovale blood from pulmonary artery through ductus arteriosus to aorta foramen ovale ->fossa ovalis ductus arteriosus->ligamentum arteriosum umbilical vein->ligamentum teres (round ligament) umbilical arteries-> lateral umbilical ligaments |
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