Term
| primary defect in Paget's disease: |
|
Definition
| abnormal bone remodeling: activation of osteoclasts and osteoblasts leads to transformation of normal lamellar and woven bone into a chaotic "mosaic" pattern of irregularly juxtaposed pieces of lamellar bone interspersed with woven bone. |
|
|
Term
| what laboratory value is elevated in Paget's disease? |
|
Definition
alk phos
as well as urinary n telopeptide |
|
|
Term
|
Definition
| low testosterone and low gonadotropin (LH and FSH) levels in the presence of a significant systemic illness. |
|
|
Term
| Pituitary tumor less than 10 mm = |
|
Definition
|
|
Term
| What is the treatment for prolactinoma? |
|
Definition
| Medical treatment with bromocriptine or cabergoline. Cabergoline is a new drug which has fewer side effects. Medical therapy not only controls prolactin levels, but reduces the tumor size. |
|
|
Term
| Most common thyroid maliganancy? |
|
Definition
| Papillary thyroid carcinoma |
|
|
Term
| Hypertension in hyperthyroid disease is primarily __________(systolic/diastolic) and caused by _________. |
|
Definition
- systolic
- hyperdynamic circulation as well as catecholemine sensitivity. |
|
|
Term
Elevated DHEA-S levels are specifically seen in pts c:
(Dehydroepiandrosterone-sulfate) |
|
Definition
| androgen producing ADRENAL tumors |
|
|
Term
| PAS positive material in the lamina propria of the small intestine: |
|
Definition
Wipple's disease.
- a multi systemic disease characterized by arthralgias, weight loss, fever, diarrhea, and abdominal pain. |
|
|
Term
| Massive doses of ASA and NSAIDS can casue: |
|
Definition
| acute erosive gastritis and upper GI bleeding. Alcohol can aggravate their effect. |
|
|
Term
| 7 things a/w chronic hep C |
|
Definition
1. cryoglobulinemia
2. B cell lymphomas
3. plasmacytomas
4. autoimmune diseases like Sjogren's and thyroiditis
5. lichen planus
6. porphyria cutanea tarda
7. idiopathic thrombocytopenic purpura |
|
|
Term
| Where do pheochromocytomas arise? |
|
Definition
| - From the chromaffin cells of the adrenal medulla. These secrete excess catecholamines such as epinephrine and norepinephrine. |
|
|
Term
| What is the treatment for a prolactinoma? |
|
Definition
| - Dopamine agonists like bromocriptine. These not only decrease the secretion of prolactin but also decrease the size of the tumor to avoid surgery. |
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