Term
| Name 6 anabolic effects of insulin |
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Definition
1. increase glucose transport in skeletal muscle and adipose
2. increase glycogen synthesis and storage
3. increase triglyceride synthesis and storage
4. increase Na+ retention (kidneys)
5. increase protein synthesis (muscles)
6. increase cellular uptake of K+ and amino acids |
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Term
| Name 6 tissues that don't require insulin for glucose uptake |
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Definition
BRICKL:
Brain
RBCs
Intestine
Cornea
Kidney
Liver |
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Term
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Definition
| transporter for glucose uptake into RBCs and brain |
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Term
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Definition
| bidirectional transporter for glucose uptake into β islet cells, liver, kidney, and small intestine |
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Term
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Definition
| Insulin responsive transporter for glucose uptake into adipose and skeletal muscle |
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Term
| 4 metabolic effects of glucagon |
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Definition
Glycogenolysis
Gluconeogenesis
Lipolysis and ketone production
Inhibition of insulin and further glucagon release |
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Term
| Affect of TRH (thyrotropin releasing hormone) from the hypothalamus (2) |
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Definition
| TSH and prolactin secretion |
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Term
| Affect of dopamine from the hypothalamus |
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Definition
| Suppresses prolactin secretion (dopamine is usually constitutively secreted to suppress prolactin) |
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Term
| Affect of CRH (corticotrophin releasing hormone) from the hypothalamus |
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Definition
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Term
| Affect of GHRH (growth hormone releasing hormone) from the hypothalamus |
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Definition
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Term
| Affect of Somatostatin from the hypothalamus (2) |
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Definition
| Suppresses GH and TSH secretion |
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Term
| Affect of GnRH (gonadotrophin releasing hormone) from the hypothalamus |
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Definition
Increases FSH and LH secretion
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Term
| Affect of prolactin from the ant. pituitary (besides milk production) |
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Definition
| Suppresses GnRH (gonadotrophin releasing hormone) secretion from the hypothalamus |
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Term
| Describe the process of prolactin regulation |
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Definition
| Prolactin secretion is inhibited by dopamine from the hypothalamus. Prolactin inhibits its own secretion by increasing dopamine secretion. |
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Term
| How to inhibit prolactin secretion in prolactinomas. (name a drug) |
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Definition
| Give dopamine agaonists like bromocriptine. |
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Term
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Definition
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Term
| Describe the secretion of Growth Hormone (somatotropin): when is it high vs low? |
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Definition
Released in pulses in response to GHRH
Increased during exercise and sleep |
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Term
| What 2 things can inhibit Growth hormone (somatotropin) release? |
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Definition
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Term
| What is the function of Growth hormone (somatotropin)? (2) How? |
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Definition
| Stimulates linear growth and muscle mass through somatomedin secretion |
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Term
| 2 affects of insulin on muscles |
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Definition
1. increase glucose transport
2. increase protien synthesis |
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Term
| Affect of insulin on kidneys |
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Definition
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Term
| 3 Affects of insulin on metabolism |
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Definition
Increases glycogen synthesis and storage
Increases triglyceride synthesis and storage
Increases cellular uptake of K+ and amino acids |
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