Term
| At what cell count are most tumors clinically detectable? |
|
Definition
|
|
Term
| What weight is considered the lethal tumor burden? |
|
Definition
|
|
Term
| In what type of cancer is surgery often used to control metastatic disease? |
|
Definition
|
|
Term
| What is the most common type of cancer emergency requiring surgical treatment? |
|
Definition
|
|
Term
| What is the genetic mutation disorder that may cause some patients to elect for colectomy? |
|
Definition
|
|
Term
| When is neo/adjuvant chemo used in relation to sugery? |
|
Definition
Neo: before to "shrink" tumor
Adjuvant: after to eradicate remaining cancer |
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Term
| Which type of chemo agents have a plateau killing effect, meaning a dose beyond which the increase will not result in further cell death: cell cycle specific or nonspecific? |
|
Definition
|
|
Term
| How is the plateau killing effect of cell cycle specific agents overcome? |
|
Definition
| Continuous infusion or daily boluses over several days --> maximizes exposure to cells in that phase of the cycle |
|
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Term
| What are some of the long-term effects associated w/ cell cycle nonspecific chemo? |
|
Definition
| Fertility, secondary cancers |
|
|
Term
| What types of cancers usually involve rescue therapy? |
|
Definition
|
|
Term
| What is febrile neutropenia? |
|
Definition
Oncologic emergency
Fever of 100.4 for more than 1hr OR single temp of 101.4 PLUS ANC (absolute neutrophil count) <500 or <1,000 and expected to fall |
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Term
| In which phase of the cell cycle do antimetabolites exert their effect? |
|
Definition
| S phase (DNA replication) |
|
|
Term
| In which phase of the cell cycle do taxanes exert their effect? |
|
Definition
| M phase (arrest microtubule movement) |
|
|
Term
| Is chemo-induced peripheral neuropathy more sensory or motor? |
|
Definition
|
|
Term
| From what fungus are the anthracyclines (antitumor abx) derived? |
|
Definition
|
|
Term
| What NT is most involved in acute chemo-induced N/V? |
|
Definition
|
|
Term
| What meds target the vomiting center in the medulla to prevent CINV? |
|
Definition
| Dopamine antagonists; histamine antagonists; cannabinoids |
|
|
Term
| What med targets the higher cortical centers of the brain contribution to CINV (fear, anticipation, etc.)? |
|
Definition
|
|
Term
| What substances are most associated with delayed CINV? |
|
Definition
|
|
Term
| How do we prevent CINV with high-risk agents? |
|
Definition
| NK-1 antagonists + 5HT antagonists + steroid (dexamethasone) |
|
|
Term
| In what types of cancer are cytokine therapies used? |
|
Definition
| Renal cell carcinoma, melanoma |
|
|
Term
| For what type of cancer is the BCG vaccine used? |
|
Definition
|
|
Term
| In what type of cancer is Sipuleucel-T therapy used? |
|
Definition
|
|
Term
| What region of the monoclonal antibody mediates its affinity for a particular antigen? |
|
Definition
|
|
Term
| What region of the monoclonal antibody mediates its ability to recruit other immune cells and molecules? |
|
Definition
|
|
Term
|
Definition
| VEGF inhibitor --> inhibits angiogenesis |
|
|
Term
| What disease state is rituximab targeted against? |
|
Definition
|
|
Term
| In what type of cancer do we use Ado-Trastuzumab Emtansine? |
|
Definition
|
|
Term
| Which Mabs are most likely to cause hypersensitivity rxn? |
|
Definition
| Murine (mouse) derived: Tositumomab, Ibritumomab |
|
|
Term
| Which Mab is least likely to cause hypersensitivity rxn? |
|
Definition
| Human derived: Panitumumab |
|
|
Term
| Targeted therapy rash most associated w/ what drug? |
|
Definition
| Cetuximab (EGFR inhibitor) |
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