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| ectoderm, mesoderm, endoderm |
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| --> epidermis, CNS, PNS, retina, etc. |
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| ---> smooth muscle, connective tissue (blood, bone, bone marrow, striated muscle), vessels, CV system, reproductive system, excretory organs |
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| ---> epthelial linings of GI/respiratory tracts, glandular cells (liver, pancreas, GI tract) |
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| thickened linear band of epiblast arising early 3rd week; appears caudally, develops caudally, then rostrally; forms mesoderm and endoderm layers |
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| proliferation of epiblastic cells at the cranial end; contains primitive pit |
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| narrow groove that forms in primitive streak resulting from invagination of epiblastic cells |
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| develops after appearance of primitive streak; epiblastic cells of deep surface that migrate; tissue consists of loosely arranged cells in gelatinous matrix |
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| ameboid, actively phagocytic cells forming mesenchyme; proliferate and differentiate widely |
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| forms from some mesenchymal cells; undifferentiated mesoderm, also embryonic mesoderm |
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| germ layer in the roof of yolk sac formed from epiblastic cells that displace hypoblastic cells |
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| cells remaining in epiblast after differentiation of 2 other germ cell layers |
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| median cellular cord of mesenchymal cells migrating cranially ---> notochordal canal |
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| notochordal process + lumen; grows cranially between endoderm/ectoderm until prechordal plate |
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| fate of prechordal plate; future site of oral cavity |
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| mesenchymal cells migrate around the prechordal plate and meet to form cardiogenic mesoderm; forms heart primordium late 3rd week |
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| caudal to primitive streak; future sitw of anus |
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| cellular rod developing from transformation of notochordal process; defines axis, basis for axial skeletal development, primary inducer of neuroectoderm, lends rigidity in absence of spinal cord |
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| thickening embryonic ectoderm induced by notochord to form neuroectoderm; primordium of CNS |
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| outpouching of yolk sac extending into connecting stalk w/ respiratory, urine storage functions, later assoc. w/ urinary bladder |
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| formation of neural tube; completed 4th week |
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| openings at rostral and caudal ends of fusing neural tube; close by end of 4th week (hopefully) |
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| invagination of the neural plate along the longitudinal median |
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| raised areas of neural plate bilateral to neural groove; first signs of brain development |
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| tube developed as neural folds fuse together |
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| neuroectodermal cells at folds that lose epithelial affinities and migrate dorsolaterally to neural tube; form neural crests |
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| flattened irregular mass of neural crest cells; give rise to sensory ganglia, ANS ganglia, meninges, pigment cells, etc. |
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| congenital abnormalities may arise from incomplete fusion of neural folds |
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| columns of embryonic mesoderm on each side of notochord; @ late 3rd week differentiates into somites |
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| blocks of mesoderm on each side of developing neural tube; develop craniocaudally, give rise to most of axial skeleton + assoc muscles + adj. dermis |
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| = embryonic body cavity; later divided into pericardial, pleural, and peritoneal cavities |
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| forms embryonic gut or splanchnopleure |
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| vasculogenesis and angiogenesis |
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| development of blood vessel |
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| mesenchymal cells that differentiate into vessel-forming cells; aggregate to form blood islands |
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| isolated angiogenic cell clusters |
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| endothelial cells of early vessels on allantois and yolk sac that form blood cells |
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| paired longitudinal endothelial-lined channels that have fused to form primordial heart tube; 3rd week |
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| 1st organ system to reach function state? |
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| cardiovascular system; 5th week |
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| secondary chorionic villi |
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| protrusions of syncytio- and cytotrophoblastic cells that now contain mesenchyme |
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| protrusions of syncytio- and cytotrophoblast containing mesenchyme and capillaries; connects embryonic cardiovascular system w/ maternal |
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| cytotrophoblastic cells that have proliferated through syncytiotrophoblast to surround chorionic sac; anchors to endometrium |
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