Term
| what binds to Fc receptors (of macrophages)? |
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Definition
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Term
| what happens when antibodies bind to Fc receptors? |
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Definition
| antibody-mediated phagocytosis |
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Term
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Definition
| several Fc receptors are bound by antibodies at the same time. Allows for phagocytosis. |
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Term
| what are one of the most important Fc receptors to remember? |
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Definition
| Fc-gamma RI. while one is inhibitory: Fc-gamma RII |
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Term
| what is an "immune complex" ? |
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Definition
| pathogen coated with antibodies |
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Term
| great summary review on slide 14 |
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Definition
| describes how different immune cells react to immune complexes |
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Term
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Definition
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Term
| what is the main phagocytic antibody? |
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Definition
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Term
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Definition
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Term
| what is the function of IgM? |
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Definition
| initiate complement cascade (since there is a short distance between the molecules) |
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Term
| what are the 3 activation pathways of complement? |
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Definition
| 1) classical, 2) mannose-binding lectin, 3) alternative |
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Term
| what does the classical pathway rely on? |
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Definition
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Term
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Definition
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Term
| what is the first step in the lectin pathway? |
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Definition
| binding of mannose-binding-lectin. |
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Term
| what happens once the MBL binds to the bacterial surface? |
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Definition
| proteases cleave C2a and C4b to then cleave C3 into C3a and C3b |
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Term
| what is the alternative pathway? |
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Definition
| spontaneous cleavage of C3 |
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Term
| what is common amongst all 3 pathways? |
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Definition
| convertase cleaves C3 into C3b which is the major component in the complement pathway |
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Term
| what is the membrane attack complex [also known as: MAC] . (PS: its at the end of the 3 different pathways) ? |
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Definition
| C5b-9 is a pore that forms in the cell membrane |
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Term
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Definition
| are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. |
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Term
| what are some of the membrane complement regulatory proteins and what do they do? |
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Definition
| keep us from killing our own cells. Some are: DAF, MCP, CR1, CD59. Found on cell surfaces. Accelerate degradation of the convertases in the 3 pathways. |
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Term
| what happens when C3b attaches to a host cell? |
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Definition
| factors H and I attach and deactivate it. |
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Term
| what happens when C3b attaches to a bacterial cell? |
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Definition
| Factors H and I do not recognize it and it becomes activated. |
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