Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
-Myopathy
-Increased liver enzymes |
|
|
Term
|
Definition
Absolute: liver disease
Relative: use with certain drugs (P450)
Pregnancy (women wanting to get preg should be removed off of statins 6-12 months in advance) |
|
|
Term
| 4 Statins with least drug-drug interactions |
|
Definition
-Pravastatin
-Fluvastatin
-Rosuvastatin
-Pitavastatin |
|
|
Term
|
Definition
-Cholestyramine
-Colestipol
-Colesevelam |
|
|
Term
|
Definition
-GI distress
-Constipation |
|
|
Term
|
Definition
| Raised TG (especially >400 mg/dL) |
|
|
Term
|
Definition
Increases levels of:
Digoxin, Warfarin, Thyroxine, and Thiazides |
|
|
Term
| Nicotinic Acid Side effects |
|
Definition
| Flushing, hyperglycemia, hyperuricemia, upper GI distress, hepatoxicity |
|
|
Term
| Nicotinic Acid Contraindications |
|
Definition
| Liver disease (use w/ caution), severe gout, peptic ulcer, uncontrolled diabetes |
|
|
Term
|
Definition
| First line agent or an alternative for tx of Hypertriglyceridemia and Diabetic hyperlipidemia. |
|
|
Term
| Nicotinic Acid: cutaneous flushing and itching |
|
Definition
| Appears to be prostaglandin mediated and can be reduced by aspirin 325mg given 30 mins before Niacin ingestion. |
|
|
Term
|
Definition
| Produces large reductions in LDL and increases in HDL. |
|
|
Term
| Niacin associated Hepatitis |
|
Definition
| More common wtih sustained release preparations. |
|
|
Term
|
Definition
-Gemfibrozil
-Fenofibrate
-Fenofibric Acid |
|
|
Term
|
Definition
| dyspepsia, gallstones, myopathy (slight myopathy) |
|
|
Term
| Fibric Acid Contraindications |
|
Definition
| Severe renal or hepatic disease |
|
|
Term
| Fenofibric Acid and Statins COMBO |
|
Definition
| Reduces TG levels and increases HDL levels in pt with mixed dyslipidemia and CHD or a CHD equivalent. |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Lowers LDL, May raise HDL, Doesnt have anything to do with TG |
|
|
Term
| Ezetimibe Contraindications |
|
Definition
-Hypersensitivity
-Pts with active liver disease or unexplained persistent elevations in serum transaminases (AST, ALT)
-Pregnant and nursing women |
|
|
Term
|
Definition
|
|
Term
|
Definition
Omega-3 fatty acids
-EPA
-DHA
Approved by FDA for the tx of high triglyceride levels
NOT used as monotherapy, ,ALWAYS used as adjunctive therapy. |
|
|
Term
| Lovaza (fish oil) Side effects |
|
Definition
| GI (burping, taste perversion, dyspepsia) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Atorvastatin + Amlodipine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Statins Monitoring Parameters |
|
Definition
Baseline: Lipids, LFT's, CPK
Test @ 6wk: Lipids, LFT's
Maintenance: Lipids and LFT's |
|
|
Term
| Niacin Monitoring Parameters |
|
Definition
Baseline: Lipids, LFT's, Glucose
Test @ 6wk: Lipids, LFT's, Glucose
Maintenance: Lipids and LFT's |
|
|
Term
| Fibrates Monitoring Parameters |
|
Definition
Baseline: Lipids, LFT's, CBC
Test @ 6wk: Lipids, LFT's, CBC
Maintenance: Lipid and LFT's, CBC |
|
|
Term
| BAS Monitoring Parameters |
|
Definition
Baseline: Lipids
Test @ 6wk: Lipids
Maintenance: Lipids |
|
|
Term
| Simvastatin with Fibrates & Nictonic Acid |
|
Definition
| Lower the dose of Simvastatin (max dose should be 10mg of Simvastatin when using with these drugs) |
|
|
Term
| Simvastatin with Amiodarone or Verapamil |
|
Definition
| Max dose of Simvastatin is 20mg when used with these drugs. |
|
|
Term
| Rosuvastatin with Fibrates and Nicotinic Acid |
|
Definition
| Lower dose of rosuvastatin when using fibrates and nicotinic acid, EXCEPT for fenofibrate (Tricor) |
|
|
Term
|
Definition
-Clinical CHD
-Symptomatic carotid artery disease
-Peripheral arterial disease
-Abdominal aortic aneurysm |
|
|
