Term
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Definition
| serotonin xporter inhibitor |
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Term
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Definition
| irrersible cox1/2 inhibitors |
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Term
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Definition
| reversible cox1/2 inhibitors |
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Term
| iproniazid, phenelzine, tranylcypromine |
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Definition
| MAO A inhib. = antidepressent activity |
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Term
| captopril, enalapril, ramipril |
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Definition
| angiotensin converting enzyme inhibitors = antihypertensive drugs |
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Term
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Definition
| dihydropteroate synthetase inhib. = no folate made |
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Term
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Definition
| dihydrofolate reductase inhib. = anticancer |
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Term
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Definition
| parasympathomimetic (m3) - assist bladder empyting, GI motility |
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Term
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Definition
| parasympathomimetic (m3) - treat glaucoma, inc tear production, treat dry mouth |
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Term
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Definition
| mAChR antag - premed for anaesthesia, treat anti-ache poisoning, treat bradycardia, treat IBS + parkinsons |
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Term
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Definition
| same as atropine + treat motion sickness |
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Term
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Definition
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Term
|
Definition
| mAChR antag - bronchdilator |
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Term
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Definition
| mAChR antag = cause mydriasis |
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Term
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Definition
| mAChR antag - cause mydriasis + loss of ability to focus on near object (via m3) |
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Term
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Definition
| mAChR antag - reversal of non-depolarising nm block (along with antiAChE), reduce excessive secretions (via m3) |
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Term
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Definition
| mAChR antag - treat urinary incontinence (dont piss yourself) |
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Term
|
Definition
| mAChR antag. - cause relaxation of detrusor muscle of bladder (via m3) = dont piss yourself |
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Term
| neostigmine, pyridostigmine |
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Definition
| anti-ache - medium action, doesnt cross BBB = increased ach transmission (depolarising block in excess) |
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Term
|
Definition
| anti-ache = long acting + crosses BBB = increased ach transmission |
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Term
|
Definition
| anti-ache - organophosphate, very potent. effects reversed by pralidoxime |
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Term
|
Definition
prevents exocytosis of ACh.
treats focal spasticity, urinary incontinence, improves appearance of wrink, involutary blinking, involuntary movement of neck |
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Term
| tubocurarine, pancuronium, vecuronium, rocuronium, astracurium, cisatracurium, mivacurium |
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Definition
non depolarising blockers
(mivacurium - broken down by plasma cholinesterase)
side effects = histamine release = hypotension/bronchoconstriction etc
USE = intubation and mechanical ventilation |
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Term
|
Definition
dopolarising blocker
causes fasciculation - phase 1 block - phase 2 block
muscle relaxant for tracheal intubation |
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Term
|
Definition
| ache = short acting, used to diagnose myastenia gravis |
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Term
|
Definition
| ache/organophosphate = used to kill head lice/mites |
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Term
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Definition
| inhibit dopa decarboxyolase (doesnt pass BBB) = levo dopa can pass BBB and be converted to dopamine = parkinsons treatment |
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Term
|
Definition
| inhibits tyrosine hydroxylase = cant make dopa from tyr = treatment for phaeochromocytoma |
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Term
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Definition
| antidepressant = inc NA via inhibition of uptake 1/net |
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Term
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Definition
| inc A (inhibits uptake 2/emt) |
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Term
| isocarboxazid, tranylcypromine, phenelzine |
|
Definition
antidepressants
inhibit mao = inc NA |
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Term
|
Definition
antidepressant
reversible inhibitor of mao = inc NA |
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Term
| ephedrine, pseudoephedrine |
|
Definition
displacing agents = cause reverse uptake of NA = inc NA at postsynaptic receptors
used as decongestants |
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Term
|
Definition
| noradrenergic neuron blocking drug = prevents release of NA + depletes nerve endings of NA = used in emergency hypertension |
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Term
| phenylephrine, xylometazoline, oxymetazoline |
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Definition
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|
Term
| clonidine, moxonide, methyldopa |
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Definition
| alpha 2 adrenoR agonist = treat hypertension |
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Term
| isoprenaline, dobutamine, dopamine |
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Definition
| mixed beta adrenoR agonists = treat cardiogenic shock/bradycardia |
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Term
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Definition
| beta 2 adrenoR agonists = treat mild asthma via bronchodilation, delay premature labour |
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Term
|
Definition
| mixed adrenoR agonist = resus from cardiac arrest, treat analphylactic shock |
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Term
| phenoxybenzamine, phentolamine |
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Definition
| mixed alpha adrenoR antagonists = treat hypertension, preop for phaeochromocytoma surgery |
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Term
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Definition
| alpha 1 adrenoR antagonist = treat hypertension, urinary retention (block a1 in sphincter of bladder = less contraction), treat raynaud's syndrome |
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Term
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Definition
| beta adrenoR antagonist = treat hypertenion, glaucoma, angina, myocardial infarct |
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Term
|
Definition
| beta 1 adrenoR antagonist = treat angina, myocardial infarct, heart failure, hypertension, glaucoma |
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Term
|
Definition
| mixed alpha/beta adrenoR antagonist = treats heart failure/hypertension (antagonises b1 in heart and a1 in bv) |
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