Term
|
Definition
| Work on GABA A channels (ionotropic); amplify effects of GABA (inactive alone); high therapeutic index; good for anxiety in the short term; also short term for insomnia; must be weaned off; withdrawals can mean seizure, death |
|
|
Term
|
Definition
| work on GABA system; have action even with no endogenous GABA (but more with GABA); higher risk of toxicity than benzos (resp and CV function); used as anesthesia inducer, anti-convulsant); can induce metabolism of other useful drugs too quickly |
|
|
Term
|
Definition
| benzodiazepine; short half-life |
|
|
Term
|
Definition
| benzodiazepine, long half-life |
|
|
Term
|
Definition
| benzodiazepine, long half life; IV use for status epilepticus |
|
|
Term
|
Definition
| benzodiazepine for insomnia, very short half life for no hangover |
|
|
Term
|
Definition
| benzo for insomnia, shortest half life |
|
|
Term
|
Definition
| benzo antagonist for overdoses; causes severe withdrawal in dependent pts |
|
|
Term
|
Definition
| barbiturate; inducer of anesthesia |
|
|
Term
|
Definition
| barbiturate; induction of anesthesia |
|
|
Term
|
Definition
| used for generalized anxiety disorder; partial serotonin receptor agonist; less sedation/interaction with depressants, more selective anxiolytic |
|
|
Term
|
Definition
| ultrashort t1/2 for sleep induction |
|
|
Term
|
Definition
|
|
Term
|
Definition
| for spasticity; acts on GABA-B receptor |
|
|
Term
|
Definition
| anti-psychotic, EP side effects |
|
|
Term
|
Definition
| anti-psychotic; best TI, EP side effects, good for cardiovascular pts. |
|
|
Term
|
Definition
| anti-psychotic; reduces EPS, may induce arrhythmias |
|
|
Term
|
Definition
| anti-psychotic; blocks 5HT and D2 receptor; no EPS, induces hunger (and diabetes) |
|
|
Term
|
Definition
| anti-psychotic; atypical (blocks 5HT/D2/alpha adrenergic receptors); few EPS |
|
|
Term
|
Definition
| anti-psychotic; atypical, few EPS, AGRANULOCYTOSIS |
|
|
Term
|
Definition
| thorazine, earliest anti-psychotic; dirty drug, bad TI |
|
|
Term
| desipramine, nortiptyline |
|
Definition
| has more potency for NE reuptake inihbition; tricyclic antidepressant |
|
|
Term
|
Definition
| blocks NE reuptake; antidepressant (no effect on 5HT, so it can be combined with an SSRI |
|
|
Term
| clomipramine, imipramine, amitryptyline |
|
Definition
| tricyclic antidepressants; more potent blockage of 5HT reuptake |
|
|
Term
| tricyclic antidepressants |
|
Definition
| all block reuptake of NE and 5-HT; also all block muscarinic receptos and alpha1 and 2 adrenergic receptors; side effects are weight gain, drowsiness, blurred vision, can cause cardiac arrythmias due to Na channel blockage; high risk of inducing mania when treating bipolar disorder |
|
|
Term
|
Definition
| inhibit MAOA and B (A important for depression); tyramine and other amines are not metabolized in liver on MAOIs and hypertensive crisis can result; also drowsiness, orthostatic hypotension, blurred vision, dry mouth, disuria, constipation |
|
|
Term
|
Definition
| similar efficacy to other antidepressants; fewer side effects; less toxicity; therapeutic after2-6 weeks; desensitization of different 5HT receptors causes increased firing rate and more 5HT release into cleft; side effects: insomnia, GI, sex dysfunction, akathesia, discontinuation syndrome |
|
|
Term
|
Definition
| SSRI; when used for bipolar has relatively low risk of producing mania |
|
|
Term
|
Definition
| SSRI, long acting; when used for bipolar has relatively low risk of producing mania |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Atypical antidepressant; blocks NE and DO reuptake; no sexual side effects; lowest risk of inducing mania when treating bipolars |
|
|
Term
|
Definition
| mood stabilizer, depletes intracellular messengers (PIP2, etc), also lowers cAMP, decreases activity of protein kinase C; augments serotonin effect (antidepressant effect) and stabilizes membranes (effects Na influx); used for episodes of mania and depression, not for rapid cycling |
|
|
Term
|
Definition
| mood stabilizer; used for rapid cycling and mixed states; acts by increasing GABA transmission + release |
|
|
Term
|
Definition
| mood stabilizer (also used for tonic clonic seizures and trigem. neuralgia); binds Na channels to decrease neuronal excitation; causes SJS |
|
|
Term
| oxacarbazepine (trileptal) |
|
Definition
| mood stabilizer; same as carbemazepine but without blood, liver symptoms |
|
|
Term
|
Definition
| mood stabilizer; effective for prevention of depressive episodes rather than mania, also effective for rapid cycling bipolar and mixed states, doesn't increase risk of switching into mania; inhibits Na channels; severe allergic rxns possible (ex SJS) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| mood stabilizer; primarily for seizures, weight loss, migranes and neuropathic pain, also for bipolar, PTSD, eating disorders (binges); acts by inhibiting Na channels, increases GABA concentration |
|
|
