Term
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Definition
| mushroom toxin, binds between F-actin molecules and prevents depolymerization |
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Term
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Definition
| Blocks binding of aminoacyl-tRNA to A-site of ribosome (only prokaryotes) |
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Term
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Definition
| Prevents the transition from initiation complex to elongation complex (prokaryotes only) |
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Term
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Definition
| Blocks the peptidyl transferase reaction (prokaryotes only, 50S) |
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Term
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Definition
| Blocks the translocation step (A-site to P-site)(prokaryotes only, 50S) |
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Term
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Definition
| Causes premature release of polypeptide chain from ribosome (Prokaryotes and Eukaryotes) |
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Term
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Definition
| Blocks the translocation step (tRNA from A-site to P-site) (Eukaryotes only) |
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Term
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Definition
| Blocks the peptidyl transferase reaction (handoff of polypeptide from one tRNA to next) (Eukaryotes only) |
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Term
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Definition
| inhibits mRNA synthesis by preventing RNA pol II from moving down DNA |
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Term
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Definition
| Treatment for malaria. Destroys malaria lysosomes. |
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Term
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Definition
| Inhibits polymerization of actin filaments. Disruption of cell morphology |
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Term
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Definition
| Inhibits polymerization of actin filaments. Disruption of cell morphology |
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Term
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Definition
| Long acting human insulin. Stabilization of insulin hexomers by methylparaben |
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Term
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Definition
| Microtubule polymerization inhibitor. Binds to tubulin subunits. Treatment for GOUT |
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Term
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Definition
| fast acting insulin. AA inversion at carboxy-terminus prevents dimer formation |
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Term
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Definition
| Anti-microtubule drug. Prevents spindle formation during mitosis. |
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Term
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Definition
| Anti-bacterial class. Inhibit protein synthesis by attacking ribosomes |
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Term
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Definition
| Treatment for Chronic Myeoloid Leukemia. Prevents the phosphorylation of Bcr-Abl. Inhibits its kinase activity. |
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Term
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Definition
| Prevents microtubule depolymerization. Anti-mitotic. |
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Term
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Definition
| Ex: Cipril, target bacterial topoisomerases. Arrest bacteria DNA replication |
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Term
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Definition
| Eukaryotic topoisomerase II inhibitor. Anti-cancer |
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Term
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Definition
| Target Zonula Occludens protein. Zoluna occludens dissociates allowing huge amount of water through the intestinal epithelium (severe diarrhea). |
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Term
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Definition
| Reduces TGF-B growth factor that is normally sequestered by fibrillin-1. (Implications in treatment for Marfan's) |
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