Term
| For some dosage forms, the size of the drug particles _______ as the drug dissolve. |
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Definition
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Term
| In Noyes-Whitney’s equation, ________ _______ is assumed to ________ _________during the process of dissolution. |
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Definition
| surface area, remain constant |
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Term
| Hixson and Crowell equation is a modified form of equation in which ... |
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Definition
| the effect of changing surface area has been taken into account. |
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Term
| According to Hixson-Crowell Cube root law, a drug powder consisting of uniformly sized particles, the dissolution rate depends on .... |
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Definition
| the cube root of the weight of the particles. |
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Term
| Methods used to determine rate of dissolution is largely dependent on .... |
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Definition
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Term
This method is used for what dissolution apparatus?
– Tablet or capsule is placed inside a stainless steel wire basket, which is rotated at a fixed speed whilst immersed in the dissolution medium that is contained in a wide mouthed cylindrical vessel. |
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Definition
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Term
| What is the Rotating Basket Method used for? |
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Definition
| – Used for dissolution of capsules, suppositories and tablets that have low density and tend to float on the dissolution medium. |
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Term
This method is used for what dissolution apparatus?
– Dosage form is allowed to sink to the bottom of the dissolution vessel before agitation is commenced. The dissolution media is continuously stirred using a paddle. |
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Definition
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Term
| The Paddle Method is used for what? |
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Definition
| Used for tablets and capsules. |
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Term
| Dissolution study is performed in an apparatus that consists of vessel for __________ __________, device for _______ the media and motor for keeping _________constant and _______ the stirring device. |
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Definition
| dissolution medium, stirring,temperature, rotate |
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Term
| Dissolution vessel is filled with ... |
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Definition
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Term
| Dissolution medium is selected based on .... |
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Definition
| the drug or dosage form or as specified in the USP. |
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Term
________ or ________ are placed inside the dissolution vessel or stainless steel wire basket,
– The wire basket is rotated or medium is stirred using a paddle.
– Sample is collected periodically and analyzed for _______ ______ |
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Definition
| tablets or capsules, drug content |
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Term
| The ________ ________ provide specific details of dissolution studies depending on the drug, dosage forms, coated and uncoated tablets. |
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Definition
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Term
| Rate of dissolution may be affected by several factors.... |
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Definition
– Solubility
– Particle size
– Crystalline state
– Drug formulation
– Physiological factors |
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Term
| Noyes-Whitney equation shows that the of a ________ _______drug is the factor that determine the dissolution of the drug. |
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Definition
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Term
| Dissolution of a drug can be increased by increasing the ... |
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Definition
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Term
| The effective surface area of a drug can be increased by ______the particle size |
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Definition
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Term
| Because dissolution is thought to take place at the surface of the solute, the greater the surface area.... |
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Definition
| the more rapid the rate of drug dissolution. |
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Term
| Different crystalline forms have different ... |
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Definition
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Term
| What kind of drug dissolves more rapidly than the same drug in a crystalline form? |
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Definition
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Term
| Excipients in a drug product may alter ... |
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Definition
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Term
| tablet lubricants such as magnesium stearate may _______ the rate of dissolution. |
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Definition
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Term
| Excipients such as ________enhance dissolution of drug. |
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Definition
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Term
| What's the time it takes for nondigestable materials to pass through stomach? |
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Definition
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Term
| Gastric emptying time greatly affects .... |
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Definition
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Term
| Presence of food alters ________ of stomach contents thus affecting dissolution |
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Definition
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Term
| ________ varies in stomach depending on contents |
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Definition
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Term
| ________ _________in the fasted state and _______ with presence of food (3.5 or above) |
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Definition
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Term
| Weakly acidic drugs will have limited solubility in a _____ pH environment, s a basic drug will dissolve _______ |
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Definition
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Term
| What is Quality Control Testing important for? Who provides its detailed guidelines? |
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Definition
| Important for testing oral solid dosage forms, US Pharmacopeia |
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Term
| Dosage form intended for a particular site of absorption must release __________ _________ to be absorbed into ________ ________ |
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Definition
| active ingredient, systemic circulation |
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Term
| After dissolution drug, where is drug bsorbed into systemic circulation (Significance of Dissolution) |
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Definition
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Term
| Define rate-limiting step (Significance of Dissolution) |
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Definition
| itdetermines the rate at which the drug reaches systemic circulation |
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Term
| In ________ drugs the absorption process is the rate limiting step(Significance of Dissolution) |
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Definition
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Term
In ______ drugs, dissolution is the rate limiting step
(Significance of Dissolution) |
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Definition
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Term
| Case 1: High Solubility – High Permeability |
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Definition
| Bioavailability not limited by dissolution |
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Term
| Case 2: Low Solubility- High Permeability |
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Definition
| Drug dissolution is rate limiting |
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Term
| Case 3: High Solubility-Low Permeability |
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Definition
| Permeability is rate limiting |
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Term
| Case 4: Low Solubility-Low Permeability |
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Definition
| Significant problems for oral drug delivery |
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