Term
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Definition
| brick shaped; dumbbell or complex shaped nucleocapsids; replicates in cytoplasm by virion encoded enzymes; has predilection for epidermal cells |
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Term
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Definition
| man only known host; extinct in 1979; seeds lungs and seeds skin after two rounds of viremia; major (15-40%rtality) and minor (1%). rash pattern is on legs and |
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Term
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Definition
| centrifugal rash pattern with vesicles all at same stage |
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Term
| small pox vaccine is based on what virus |
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Definition
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Term
| pox virus with clear pustules; direct contact |
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Definition
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Term
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Definition
| HSV-1, HSV-2, VZV; latency in trigeminal nerve, sacral ganglia and posterior root thoracic ganglia or cervical ganglia respectively |
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Term
| How does HSV get to the neuron cell body? |
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Definition
| It moves via retro-axonal flow; it integrates into cell body DNA and goes into latency; stress, age, immune activation triggers acute infection |
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Term
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Definition
| Epstein-Barr Virus; Human Herpes 8 virus |
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Term
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Definition
| infects B cells, oropharyngeal epithelial cells and other susceptible lymphocytes; CR2 receptor and MHC II coreceptor for attachment |
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Term
| how does EBV affect B and T cells |
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Definition
| It acts as a B cell mitogen and a lot of IgM termed heterophile antibody is produces; prevents B cell apoptosis; Cytotoxic T cells replicate into abnormal T cells to control B cell proliferation |
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Term
| swollen glands, fever, malaise, pharyngitis and extreme fatigue |
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Definition
| heterophile antibody positive infectious mononucleosis |
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Term
| what are some consequences of heterophile antibody production |
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Definition
| the antibodies can be directed at self, non-self, medications etc. |
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Term
| In EBV lymph swelling is caused from what? |
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Definition
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Term
| what cancers are associated with EBV? |
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Definition
| Burkitt's Lymphoma in Africa (tumor of jaw and abdomen); nasopharyngeal cancer in China; Many Hodgkin's lymphomas; lymphomas in the immunocompromised |
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Term
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Definition
| the primary and necessary factor in this sarcoma is HHV-8; also associated with lymphoproliferative disorders; transmitted sexually; asymptomatic in immunocompetent people |
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Term
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Definition
| heterophile negative mono in some healthy people; mostly immunocompromised --> jaundice hepatoslenomegaly; severe neurological damage to fetus in utero |
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Term
| latency in monocytes; reactivation results in shedding in urine |
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Definition
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Term
| women who might be pregnant should exercise caution in daycare setting |
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Definition
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Term
| most common febrile exabthum in infants under 2 yrs |
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Definition
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Term
| marked tropism for CD4 cells, epithleial cells, salivary glands and latent in PBMC; 3-5 days of high fever and macupapulary rash |
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Definition
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Term
| salivary gland chronic infection |
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Definition
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Term
| enveloped icosahedral nucelocapsids; ; assembled in nucleus; intranuclear inclusion bodies; bud through the innder nuclear membrane; latent or chronic infection |
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Definition
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Term
| dsDNA; naked icosahedral nucleocapsids; 49 serotypes; prolonged survival time outside the body |
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Definition
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Term
| ARD in military; common cold and LRTI, conjunctivitis; occasionally causes left ventricular dysfunction; latent and persistent infection in tonsils |
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Definition
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Term
| what is on the outside of adenovirus capsid? |
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Definition
| fiber knob and pentone base |
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Term
| cause the croup pneumonia and the common cold |
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Definition
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Term
| can adenovirus make it down through the GI? |
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Definition
| yes silly its a naked virus; gastroenteritis and cystitis |
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Term
| naked icosahedral nucleocapsids; integrate into host genome |
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Definition
| Papovaviridae; oncogenic potential |
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Term
| oncogenic potential; latent or chronic infections in host; naked |
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Definition
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Term
| has circular double stranded DNA |
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Definition
| HPV; cancerous strains 16 and 18, wart strains 6 and 11 |
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Term
| describe oncogenesis of HPV cervical cancer |
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Definition
| chromosome integrates into host DNA and this disrupts the E2 gene on virus DNA. The E2 gene is what downregulates gene expression of E6 and E7. E6 and E7 bind to Rb and p53 and inhibit the inhibitors of cell division |
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Term
| can skin warts become cancer? |
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Definition
| yes... epidermosdysplasia verruciformis -- multiple skin warts exposed to sun can become squamous carcinoma |
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Term
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Definition
| localize in kidney; localize in kidney monocytes and B cells; latency; recurrence can lead to serious diseas; JC recurrence can lead to progressive multifocal encephalopathy |
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Term
| naked icosahedral; 5th disease; aplastic anemia in those with sickle cell; fetal infection canbe fatal-hydrops fetalis; adult polyarticular arthritis |
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Definition
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Term
| grows in erythropoetic cells |
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Definition
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Term
| icosahedral enveloped virus; nicked circular DNA; reverse transcriptase |
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Definition
| Hep B virus; serum hepatitis or long-incubation hepatitis |
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Term
| what is the vaccine for Hep B made of |
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Definition
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Term
| Two possible mechanisms for Primary hepatocellular carcinoma |
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Definition
| repeat damage to hepatocytes due to immune activation; insertion of viral DNA into chromosome and disruption of regulatory genes |
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Term
| how is disease progress different between perinatal contraction and adult contraction |
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Definition
| 70-90% develop chronic hep b and 5-10% respectively |
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Term
| How does chronic HBV develop? |
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Definition
| weak cell mediated immunity |
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Term
| what is responsible for liver damage in HBV infection |
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Definition
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Term
| 2 outcomes of HBV infection? or latenct carrier state? |
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Definition
| chronic liver disease and/or PHC |
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Term
| in what type of cells do DNA viruses typically cause cancer? |
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Definition
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