Term
| What is the rate limiting step in purine synthesis? |
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Definition
| Glutamine PRPP Aminotransferase |
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Term
| What is the rate limiting step in pyrimidine synthesis? |
|
Definition
| Carbamoyl phosphate synthetase II |
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Term
| What are the sources of carbons in the formation of purines? |
|
Definition
| CO2, Tetrahydrofolate, Glycine |
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Term
| What are the sources of carbons in pyrimidine synthesis? |
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Definition
|
|
Term
| What accounts for the positive charge of histones? |
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Definition
|
|
Term
| What accounts for the negative charge of DNA? |
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Definition
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Term
| How many adenin residues are found in a molecule of DNA is one strand contains A=2000, G=500, C=1500, T=1000 |
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Definition
|
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Term
| What strand of DNA nucleotides opposes this strand of DNA: 5'-ATTGCGTA-3' |
|
Definition
always written 5'-3'
TACGCAAT |
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Term
| What medication inhibits ribonucleotide reductase? |
|
Definition
|
|
Term
| What medication inhibits dihydrofolate reductase? |
|
Definition
| Methotrexate, trimethoprim |
|
|
Term
| What medication inhibits thymidylate synthase? |
|
Definition
|
|
Term
| What medication inhibits inosine monophosphate dehydrogenase? |
|
Definition
|
|
Term
| What medication inhibits PRPP synthetase |
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Definition
|
|
Term
| What are the characteristic features of orotic aciduria |
|
Definition
| Megaloblastic anemia that doesn't improve with B12 or folate administration, failure to thrive, orotic acid in urine |
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|
Term
| What antibiotics inhibit 50S peptidyltransferase? |
|
Definition
| Chloramphenicol, Streptogramins |
|
|
Term
| What antibiotics binds 50S blocking translocation? |
|
Definition
|
|
Term
| What antibiotics bind 30S preventing attachment of tRNA? |
|
Definition
|
|
Term
| What antibiotics inhibit prokaryotic RNA polymerase |
|
Definition
|
|
Term
| What antibiotics inhibit prokaryotic topisomerase |
|
Definition
|
|
Term
| What antibiotics inhibit prokaryotic dihydrofolate reductase |
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Definition
|
|
Term
| What are the 3 different mechanisms cells employ to break down proteins? |
|
Definition
Ubiquitin mechanism
Lysosomal degradation mechanism
Calcium dependent enzyme mechanism |
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|
Term
| What enzyme catalyzes peptide bond formation during protein synthesis? |
|
Definition
|
|
Term
| What enzyme matches amino acids to tRNA? |
|
Definition
|
|
Term
| What are the mRNA stop codons? |
|
Definition
|
|
Term
| What are the different RNA polymerases in eukaryotes? |
|
Definition
RNA polymerase I: codes for rRNA
RNA polymerase II: transcribes mRNA
RNA polymerase III: transcribes tRNA |
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|
Term
| What amino acid frequently has more coding sequences in the mRNA than are represented in the peptide that is created from the mRNA? |
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Definition
|
|
Term
| How is hnRNA processed before it leaves the nucleus? |
|
Definition
Gets a 5' cap
Poly-A tail
Splicing out of introns |
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|
Term
| What is the characteristic sequence of the promotor region? What does a mutation in this sequence cause? |
|
Definition
-25 TATA box
-75 CAAT box
decrease in the amount of gene that gets transcribed |
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|
Term
| What enzyme is deficient in Lesh-Nyhan syndrome? What is the tx? |
|
Definition
|
|
Term
| What structural motifs allow for proteins to bind DNA? |
|
Definition
Helix turn helix
Helix loop helix
Leucine zippers
Zinc fingers |
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