Term
| what classes of drugs commonly cause constipation? |
|
Definition
| Calcium blockers, anti-hypertensives, anti-depressants, pain meds |
|
|
Term
| What is the MOA of Linaclotide as an Osmotic agent? |
|
Definition
| Through microbial mimicry, it acts like cholera toxin to activate cGMP |
|
|
Term
| Why is Methylnaltrexone good as a laxative |
|
Definition
| while not affecting analgesic effects of opioids?,It cannon cross the BBB so it acts on GI mu receptors, antagonizing them without affecting central analgesia |
|
|
Term
| What is the effect of 5HT2 antagonists and what are the 5 of theM? |
|
Definition
|
|
Term
|
Definition
| Odanestron, dolasetron, Alosetron, Cilansetron |
|
|
Term
| What are the 4 5HT4 agonists? |
|
Definition
| cisapride, Norcisapride, Purcalopride, *Tegaserod |
|
|
Term
| What cells are responsible for the primary secretion of Serotonin? |
|
Definition
|
|
Term
| Is IBS a disorder of function or structure? |
|
Definition
|
|
Term
| Who does IBS affect more commonly? |
|
Definition
|
|
Term
| Where is the most common site of Chron's disease? |
|
Definition
|
|
Term
| Is Chron's or Ulcerative Colitis full thickness? |
|
Definition
|
|
Term
| When is Budesonide more effective than Mesalamine for Chron's? |
|
Definition
| When it is in the ileum or ascending colon or both |
|
|
Term
| how are the biologic agents such as Infliximab |
|
Definition
| Adalimumab, Certolizumab, and Natalizumab, which are used for Inflammatory Bowel Disease, administered?,injected because they are Ig's |
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