Term
| meds that increase risk of gallstone formation.. |
|
Definition
1. oral contraceptive (estrogen therapy)
2. octreotide
3. fibrates (clofibrate)
4. ceftriaxone |
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Term
| Meds that increase risk of pancreatitis.. |
|
Definition
1. 5-aminosalicyclic acid
2. asparaginase
3. azathioprine
4.didanosine
5.estrogen
6. furosemide
7. mercaptopurine
8. methyldopa
9.metronidazole
10. pentamidine
11. sulfonamide
12.sulindac
13.tetracycline
14.thiazides
15. valproic acid |
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Term
| meds that may induce liver toxicity... |
|
Definition
1.apap
2. valproate
3. iron |
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|
Term
| cyp inducers.. (food and meds) |
|
Definition
| 1. brussel sprouts 2. cabbage 3. charcoal foods 4. chronic alcohol ingestion 5. phenytoin 6. carbapazepine 7. phenobarbital 8. rifampin |
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Term
| inhibition of cyp.. (food and meds) |
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Definition
| 1. grapefruit juice 2. erythromycin 3. clarithromycin 4. azoles 5. protease inh 6. cimetidine 7. omperazole 8. esomeprazole |
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|
Term
| age has an effect on phase 1, phase 2 or both? |
|
Definition
|
|
Term
| decreased albumin may lead to increase or decrease of free drug for phase 1 &2 metabolism? |
|
Definition
|
|
Term
| Phase II enzyme activity does not appear to be altered in most liver disease.. true or false? |
|
Definition
|
|
Term
| liver disease will effect which phase of metabolism... |
|
Definition
|
|
Term
| what can cause cholestatic jaundice? |
|
Definition
1. high dose of estrogen
2.amiodarone |
|
|
Term
| what can cause veno-occlusive disease? |
|
Definition
| androgens, estrogen, danazol |
|
|
Term
| what can cause steatohepatitis? |
|
Definition
1. tetracycline
2.valproate
3. amiodarone
4. TPN |
|
|
Term
| Toxic hepatocellular injury may be devided into two broad groups.. (name them and the subgroup) |
|
Definition
1. direct chemical rxn
a) intrinsin hepatotoxins
b)toxic metabolites
2. idiosyncratic reactions
a) immune-mediated hypersensitivity |
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|
Term
| Drugs that have intrinsic hepatotoxicity in lare doses.. |
|
Definition
| 1. apap 2. iron sulfate 3. methotrexate (other chemo's) 4. IV tetracycline |
|
|
Term
| Drugs that have intrinsic hepatotoxicity in large doses.. |
|
Definition
| 1. apap 2. iron sulfate 3. methotrexate (other chemo's) 4. IV tetracycline |
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|
Term
| meds that produce toxic metaobolite.. |
|
Definition
| 1. isoniazid 2. apap 3. ketoconazole 4. amiodarone 5. valproate |
|
|
Term
| symptoms of hypersensitivity rxn and the the onset (time frame)... |
|
Definition
| sx: 1. rash 2. fever 3. joint pain 4. inflammation 5. eosinophilia 6. leukocytosis |
|
|
Term
| severe case of hypersensitivity rxn called.. |
|
Definition
stevens-johnson syndrome
body attacks own skin and you become immuno comprimised |
|
|
Term
| Drugs that induce hypersensitivity rxns.. |
|
Definition
| 1. phenytoin 2. carbamazepine 3. allopurinol 4. most abx a. augmentin b. sufamethaxozole c. dapsone d. flouroquinolines |
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|
Term
| liver biopsy will reveal what during a hypersensitivity rxn? |
|
Definition
| eosinophils or inflammation of the liver |
|
|
Term
| meds that can cause cholestasis... |
|
Definition
1. estrogen
2. amiodarone
3.chlorpromazine
4.captopril
5.antiobiotics (sulf, rifamipin, eryth) |
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|
Term
| meds that can cause steatosis.. |
|
Definition
| 1. tetracycline 2. valproate 3. amiodarone 4. methotrexate 5. zidovudine 6. stavudine 7. didanosine 8. tpn |
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