Term
| rank fat, muscle and liver in terms of insulin sensitivity |
|
Definition
fat > liver > muscle
(fat most sensitive) |
|
|
Term
| fat, liver and muscle response to insulin |
|
Definition
fat: inhibit lipolysis
liver: inhibit GNG
muscle: uptake glucose |
|
|
Term
| screening recommendations |
|
Definition
every 3yrs >35yo
every 1yr if risk factors+ |
|
|
Term
| normal FPG, 2hPG, and HbA1c |
|
Definition
FPG <100
2hPG <140
A1c < 5.7 |
|
|
Term
| pre-diabetic FPG, 2hPG, and HbA1c |
|
Definition
100 < FPG < 126
140 < 2hPG < 200
5.7 < A1c < 6.4 |
|
|
Term
| diabetic FPG, 2hPG, and HbA1c |
|
Definition
FPG > 126
2hPG > 200
A1c > 6.4 |
|
|
Term
|
Definition
| DKA, polyuria, polydypsia, polyphagia, muscle wasting, weight loss |
|
|
Term
| most common cause of death in diabetics |
|
Definition
|
|
Term
|
Definition
| retinopathies, renal disease, CAD, peripheral neuropathies |
|
|
Term
| type 1 DM is autoimmune and [cell/antibody] mediated |
|
Definition
|
|
Term
DM type 1 is associated with HLA-___?
Which HLA is protective? |
|
Definition
HLA-DR3 and DR4
DR2 is protective |
|
|
Term
| antibodies in type 1 DM target... |
|
Definition
|
|
Term
|
Definition
| beta cell dysfunction + insulin resistance |
|
|
Term
|
Definition
| HTN, dyslipidemia, pro-inflammatory, pro-coagulant state, endothelial dysfunction, obesity, insulin resistance |
|
|
Term
| diagnostic criteria for metabolic syndrome |
|
Definition
| any 3: waist >40"M or >35"F, LDL >40M or >50F, TAG>150, BP>130/85, FPG>100 |
|
|
Term
| 35yo thin pt with hx of type 2 DM presents with DKA and is positive for autoantibodies; dx? |
|
Definition
|
|
Term
| 25yo thin pt with hx of type 2 DM presents with DKA and is negative for autoantibodies; dx? |
|
Definition
|
|
Term
screening recommendations for gestational diabetes?
diagnostic criteria? |
|
Definition
screen during 2nd trimester
dx: 96 < FPG < 126 |
|
|
Term
| complications of gestational diabetes |
|
Definition
| fetal macrosomia, childhood metabolic syndrome |
|
|
Term
| when does gestational diabetes occur? |
|
Definition
|
|
Term
| pathogenesis of gestational diabetes? |
|
Definition
| HPL, estrogen, and progesterone increase insulin resistance |
|
|
Term
| autosomal dominant, monogenic disease of young adult that present with DKA |
|
Definition
|
|
Term
| 35yo obese pt with hx of type 2 DM presents with DKA; dx? |
|
Definition
|
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