Term
|
Definition
| myelin destruction out of proportion to axonal damage |
|
|
Term
| define actutes, disseminated excephalomyelitis |
|
Definition
| a single episode, with inflammatory CSF, that does not nec evolve to MS, can be recurrent in kids |
|
|
Term
| what is a clinically issolated syndrome? |
|
Definition
| a single episode of demyelination (ie, optic neuritis) |
|
|
Term
| Compare and contrast MS and Acute disseminated encephalomyelitis |
|
Definition
| ADE = acute, MS = chronic |
|
|
Term
|
Definition
| a chronic, progressive immune-mediated CNS disease characterized by demylination and axonal loss leading to neurological impairment and disability. early treatment is key. |
|
|
Term
| Is MS itself often directly fatal? |
|
Definition
|
|
Term
| Which viruses are suspected to cause MS? |
|
Definition
| Rabies, EBV, HHV-6, HTLV Lyme Disease |
|
|
Term
| Which deficiency may cause MS? |
|
Definition
|
|
Term
| Is there a genetic component to MS? |
|
Definition
|
|
Term
| Where is there highest concentration of people with MS? Lowest? |
|
Definition
Highest- N. US/Canada, Western Europe
Lowest--africa |
|
|
Term
| Where are the most susceptible parts of the CNS to MS demylenation? |
|
Definition
| MS can involve any area of CNS, but optic nerve and spinal cord are most symptomatic. |
|
|
Term
|
Definition
| Yes--from single episode of demyelination (monosymptomatic demyelinating disease of clnical isolated syndrome) to a continous neurological deterioration with or without occasional acute worsening. |
|
|
Term
| What are the 2 classic symptoms of MS? |
|
Definition
| visual symptoms and difficulty of ambulation |
|
|
Term
| What are the 2 other symptoms of MS? |
|
Definition
| cognitive problems, and sensitivity to high temp (symptoms get worse. |
|
|
Term
| what is average age of onset |
|
Definition
|
|
Term
| Do more men than women get it? |
|
Definition
|
|
Term
| Name the 4 MS classification: |
|
Definition
Monosymptomatic demyelination (Not MS, but it can predispose)
2. Relapsing remitting
3. Secondary progressive (fewer "episodes," just get progressively worse)
4. Primary progressive. No relapses, just get worse. It's a bad type of MS--not much inflammation--and we only have drugs to treat the inflammation. |
|
|
Term
| Define MS related optic neuritis |
|
Definition
Monocular loss of vision,
2. pain
3. Optic swelling followed by atrophy
4. prolonged visual evoked responses (VERs)
5. recovery with time. |
|
|
Term
| List Optic symptoms of MS |
|
Definition
1. Looks at a pattern reversal (checked squares)
2. prolonged delay indicative of visual dysfuction.
3. internuclear ophthalmoplegia |
|
|
Term
| define internuclear ophthalmophegia |
|
Definition
| VOR doesn't work--2 eyes can't follow finger |
|
|
Term
| Does prescence of oligoclonal bands suggest normal or MS? |
|
Definition
|
|
Term
|
Definition
| sensory complaints (pain, LOsens), ambulatory difficulties, loss of upper extremity coordination |
|
|
Term
| What are the 3 different types of MS Path, and what do they mean? |
|
Definition
1. Contrast Enhancing Lesion--inflammation
2. White Matter Lesion--demyelination
3. Black Hole--axonal loss/gliosis |
|
|
Term
|
Definition
| lesions=areas of demyelination = lymphocytes, macrophages |
|
|
Term
| what is the biggest change over time in terms of how the disease manifests itself? Ie, early vs late main components. |
|
Definition
1. Early--inflammation, demylenation (relapse)
2. Late--atrophy, axonal loss, increasing tissue destruction (disability) |
|
|
Term
|
Definition
| IFN--Betas--shown to have fewer lesions |
|
|
Term
| what effects do we want to have future MS treaments? |
|
Definition
| agents that decrease lymphocitye and monocyte recruitment into CNS |
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