Term
| inhibits enzyme required for synthesis of purines (adenine and guanine) |
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Definition
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Term
| inhibits purine and thymidine synthesis through inhibiting enzymes |
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Definition
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Term
| inhibits DNA synthesis by blocking de nove (from new) guanine synthesis |
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Definition
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Term
| pro-drug gets converted in liver to alkylating agent--> binds to DNA and cross-links it--> prevents DNA replication and protein production |
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Definition
| Cyclophosphamide and Chlorambucil |
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Term
| prevent proliferation or kill rapidly-dividing cells; target actively dividing cells |
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Definition
| Cytotoxic and Anti-proliferative Immunosuppressive Drugs |
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Term
| Block T cell activation and proliferation by inhibiting IL-2; work by binding immunophilins-->cyclophilin and FK-BP |
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Definition
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Term
| inhibits T cell activation by blocking IL-2 production |
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Definition
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Term
| Inhibits Calcineurin activation |
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Definition
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Term
| Blocks signals from IL-2 receptor in T cells; often over-expressed in cancer cells |
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Definition
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Term
| more specific for immune cells, selective for T cells, less hematotoxic, myelotoxic |
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Definition
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Term
| all specific for same epitope/antigeon; antigen specificity is high, cross reactions are low |
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Definition
| monoclonal antibodies (mAb) |
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Term
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Definition
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Term
| can opsonize, fix C, ADCC < block |
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Definition
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Term
| can block, can deliver cytotoxic conjugates to target cell; better tissue penetration and less immunogenic |
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Definition
| Fab, or fab2 fragments (mAb drugs) |
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Definition
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Definition
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Definition
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Definition
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Definition
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Term
| destroys T cells: recognizes CD3, causes T cell to be opsonized |
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Definition
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Definition
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Term
| serves as spong by binding TNF alpha which sequesters it and prevents it from activating TNF alpha receptors |
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Definition
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Term
| binding TNF alpha to block it (chimeric mAb) |
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Definition
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Term
| binding TNF alpha to block it from binding its receptors (human mAb) |
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Definition
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Term
| Pegylated humanized fab to TNF alpha; Fab fragment is able to block TNF alpha |
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Definition
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Term
| recombinant form of a naturally occuring IL-1 receptor antagonist |
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Definition
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Term
| humanized mAb binds IL-6 receptor to keep IL-6 from binding |
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Definition
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