Term
|
Definition
| metabolizes nitrates to NO and S-nitrothiols |
|
|
Term
|
Definition
| converts GTP to cGMP, activated by NO and S-nitrothiols |
|
|
Term
|
Definition
| metabolizes ranolazine, statins |
|
|
Term
|
Definition
| two dimers, starts to rise after 2h of MI, peaks at 24h, normal by 72h |
|
|
Term
|
Definition
| in skeletal and cardiac m, elevated at same time as CKMB, remains elevated 7-10d |
|
|
Term
|
Definition
| rate-limiting step in cholesterol synthesis, inhibited by statins and monacolins |
|
|
Term
|
Definition
| activated by statins, upregulates LDL-R to increase serum LDL uptake |
|
|
Term
|
Definition
|
|
Term
|
Definition
| coverts fibrinogen to fibrin |
|
|
Term
|
Definition
| cross-links adjacent fibrin monomers |
|
|
Term
|
Definition
| serine protease, digest fibrin, A-chain is lysine binding site, B-chain has enzymatic activity, indiscriminate fibrin lysis leads to systemic lytic state |
|
|
Term
|
Definition
| inactive zymogen of plasmin, synthesized in liver, converted by cleavage of Arg560, binds fibrin ad lysine-rich residues at N-terminus |
|
|
Term
|
Definition
| binds same site as fibrin, fibrin-bound plasmin is protected, forms a covalent complex with plasmin |
|
|
Term
|
Definition
| serine proteases, released from ECs, rapidly cleared from blood, inhibited by PAI-1/2, convert plasminogen to plasmin, very poor activator without fibrin |
|
|
Term
|
Definition
| inhibit ternary fibrin/plasminogen/tPA complex |
|
|
Term
|
Definition
| deleted in Alagille Syndrome |
|
|
Term
|
Definition
| deleted in Noonan Syndrome |
|
|
Term
|
Definition
| deleted in Holt-Oram syndrome |
|
|
Term
|
Definition
| deleted in DiGeorge Syndrome |
|
|
Term
|
Definition
| deleted in Williams Syndrome |
|
|
