Term
| What is the most common connective tissue disease? |
|
Definition
| systemic lupus erythematosus |
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Term
| What is the second most common connective tissue disease? |
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Definition
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Term
|
Definition
|
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Term
| What three general factors determine lupus? |
|
Definition
genetic
enviornmental
immunologic |
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Term
| What type of hypersensitivity is lupus? |
|
Definition
|
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Term
| What are the four most common causes of death in a lupus patient? |
|
Definition
Renal Failure
Infection
CNS complications
Coronary artery disease |
|
|
Term
| What occurs to the small vessels in lupus? |
|
Definition
|
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Term
| What disease presents with palpable purpura and why? |
|
Definition
| Lupus due to the small vessel vasculitis |
|
|
Term
| What characteristic finding of lupus is sensitive to light? |
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Definition
|
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Term
| What is the difference between the joint disease of lupus and rheumatoid arthritis? |
|
Definition
RA is destructive synovitis
Lupus in non-destructive |
|
|
Term
| What does the synovitis in lupus cause? |
|
Definition
|
|
Term
| What is the most common manifestation of lupus? |
|
Definition
| symmetric polyarthralgias |
|
|
Term
| What disease presents with serous membrane inflammation? What are the common sites? |
|
Definition
Lupus
Pericarditis
Pleuritis
Peritonitis |
|
|
Term
| Why do lupus patients have an increase risk of Coronary Artery Disease? |
|
Definition
| b/c they have accelerated artherosclerosis |
|
|
Term
What disease presents with antiphospholipid antibody syndrome and what does it cause?
What disease does this make this disease often get confused with? |
|
Definition
Lupus
Anitphospholipid antibody syndrome causes and increase in coagulation
Syphilis |
|
|
Term
| What are the most diagnositic tests for lupus? (2) |
|
Definition
dsDNA
Smith antigen (small nuclear ribonucleoprotien) |
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Term
| 45 y/o Female presents with arthralgia in both knees. She has also noticed a rash under her eyes. In addition, she notes that when she is in the sun, this rash often is painful. What is the most likely diagnosis? What tests would you want to order? |
|
Definition
Systemic Lupus erythematosus
order smith antigen and dsDNA test |
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Term
| What disease presents with scaring of the skin and organs due to narrowing of vessels? |
|
Definition
| systemic sclerosis (scleroderma) |
|
|
Term
| What are the two categories of scleroderma? What are the general characterisitics of both? |
|
Definition
diffuse: rapid progression, generalized skin lesions, organ involvement
limited- less skin involved, slower progression, CREST |
|
|
Term
| What does CREST stand for? |
|
Definition
Calcinosis of skin
Reynauds phenomenum
Esophageal dysfunction(dysphagia, large diverticuli)
Sclerodactyl
Telengiectasia
|
|
|
Term
| What disease presents with antibody to centrosome? |
|
Definition
|
|
Term
| What is true of the skin in scleroderma? |
|
Definition
|
|
Term
| Where are the most likely locations (2) that scleroderma will present in skin? |
|
Definition
|
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Term
|
Definition
|
|
Term
| What disease presents with stone facies or mask like face? |
|
Definition
|
|
Term
| What is Reynauds Phenomenon? |
|
Definition
vasoconstriction leading to ishemia and thus causing triple color change
white to blue to red |
|
|
Term
| What are the two most common GI manifestations of Scleroderma? |
|
Definition
dysphagia
large mouth diverticula |
|
|
Term
| What is the most likely cause of death in scleroderma? |
|
Definition
|
|
Term
| What is sclerodermal renal crisis? |
|
Definition
| ischemia in kidney leads to renal hypertension and eventually renal failure |
|
|
Term
| What connective tissue diseases have risks of malignancy? |
|
Definition
|
|
Term
| What disease is associated with B-cell lymphoma risk? |
|
Definition
|
|
Term
| What is keratoconjunctivitis sicca? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What occurs to lacrimal and salivary glands in Sjogren's Syndrome? |
|
Definition
| they atrophy, fibrosis, and eventually destruct |
|
|
Term
| What two antibodies are seen in Sjogren's? |
|
Definition
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