Term
| The complement system is made up of how many globulins (Plasma proteins)? |
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Definition
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Term
| Where are globulins of the Complement System synthesized? |
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Definition
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Term
| Where are globulins of the Complement System always present in an active state? |
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Definition
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Term
| What activates globulins of the Complement System? |
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Definition
| the presence of a pathogen |
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Term
| What mechanism is similar to the Complement System and why? |
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Definition
| Blood Clotting Mechanism because it happens in steps. |
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Term
| What are the three routes of activation of the Complement System? |
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Definition
1. Classic Pathway
2. Alternative Pathway
3. Lectin Pathway |
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Term
| Any substance that illicits an immune reaction |
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Definition
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Term
| This is present most of the time on the surface of cells |
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Definition
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Term
| What do Pathogens contain that illicit a response? |
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Definition
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Term
| what produces an antibody to join with Foreign Antigens |
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Definition
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Term
| Antibodies joined with Antigens make? |
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Definition
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Term
| This attracts complement to bind to it and begin a chemical cascade |
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Definition
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Term
| What acts as a neon sign that says "Foreigner here!" so that Complements will know where to bind? |
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Definition
| Antigens (Ours not foreign) |
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Term
| Antigen + Antibody + Complements =? |
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Definition
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Term
| what causes the chemical activation of the complement |
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Definition
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Term
| The Classic Pathway is what type of Defense |
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Definition
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Term
| Antibodies have what kind of targets? |
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Definition
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Term
| Anytime an Antibody is present it is what type of Defense? |
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Definition
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Term
| C3 is part of what pathway? |
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Definition
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Term
| An Antibody is part of what pathway? |
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Definition
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Term
| C3 breaks into smaller fragments that bind directly to? |
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Definition
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Term
| What is the result of all three pathways? |
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Definition
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Term
| The Alternative Pathway is what type of method? |
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Definition
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Term
| These are plasma proteins that tend to bind to carbohydrates but also bind to the surface of pathogens and cause a chemical cascade |
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Definition
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Term
| What are the four methods that Activated Complements use to destroy pathogens |
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Definition
1. Inflammation
2. Immune Clearance
3. Phagocytosis
4. Cytolysis |
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Term
| Which is the only method that activated complment uses to destroy pathogens that is a DIRECT Method? |
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Definition
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Term
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Definition
| Compliment stimulates Basophils and Mast Cells to release Histamine and other inflammatory chemicals. Complement activates and attracts Neutrophils and Macrophages because they will eat the pathogen. |
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Term
| during imglammation, why does complement activate and attract Neutrophils and Macrophages to the area? |
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Definition
| so that they will eat the pathogen |
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Term
| In inflammation, what does complement stimulate to release histamind and other inflammatory chemicals? |
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Definition
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Term
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Definition
| Complement causes antigen antibody complexes to attach to RBC's. As RBC's go thru the liver and spleen, macrophages remove and destroy the pathogens leaving the RBC's unharmed. |
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Term
| During Immune CLearance, what does complement cause antigen antibody complexes to attach to? |
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Definition
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Term
| During Immune Clearance, RBC's with antigen antibody complex attached, travel thu what organs? |
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Definition
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Term
| During Immune Clearance, what removes the pathogen in the liver and spleen? |
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Definition
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Term
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Definition
| Neutrophils and Macrophages perform this. The complement promotes phagocutosis by a process called opsonization which caots the pathogen making them easier to phagocytize. |
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Term
| the process of placing an outer coating on a pathogen for easier phagocytizing |
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Definition
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Term
| what performs Phagocytosis? |
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Definition
| Neutrophils and Macrophages |
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Term
| Complement promotes phagocytosis by what process? |
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Definition
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Term
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Definition
| Splitting/Breaking of cells. A group of complement proteins form a ring called a membrane attack complex (MAC). THis MAC attaches to the membrane of the pathogen and punches a hole to cause the cell to rupture. |
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Term
| In Cytolysis, A group of complement proteins form a ring called? |
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Definition
| a Membrane Attack Complex (MAC) |
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Term
| What does a MAC do to a pathogen in Cytolysis? |
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Definition
| Attaches to the membrane of the pathogen and punches a hole in it causing the cell to rupture. |
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