Term
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Definition
chlorpromazine
fluphenazine
thioridazine |
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Term
| CHLORPROMAZINE (THORAZINE) |
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Definition
ANTIPSYCHOTIC (PHENOTHIAZINE DERIVATIVE WITH aliphatic side chain)
Machanism by D2 receptor: antagonist of D2, inhibit adenylate cyclase, block PKA, inhibit NMDAR mediated glutamate transmission and LTP |
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Term
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Definition
ANTIPSYCHOTIC (PHENOTHIAZINE DERIVATIVE WITH piperazine side chains)
Machanism by D2 receptor: antagonist of D2, inhibit adenylate cyclase, block PKA, inhibit NMDAR mediated glutamate transmission and LTP |
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Term
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Definition
ANTIPSYCHOTIC (PHENOTHIAZINE DERIVATIVE WITH piperidine side chains)
Machanism by D2 receptor: antagonist of D2, inhibit adenylate cyclase, block PKA, inhibit NMDAR mediated glutamate transmission and LTP |
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Term
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Definition
ANTIPSYCHOTIC (THIOXANTHENE DERIVATIVE)
Machanism by D2 receptor: antagonist of D2, inhibit adenylate cyclase, block PKA, inhibit NMDAR mediated glutamate transmission and LTP |
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Term
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Definition
ANTIPSYCHOTIC (BUTYROPHENONES)
Machanism by D2 receptor: antagonist of D2, inhibit adenylate cyclase, block PKA, inhibit NMDAR mediated glutamate transmission and LTP |
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Term
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Definition
NEW GENERATION ANTIPSYCHOTIC
Mechanism by 5-HT receptors - antagonist of 5-Ht, activate PLC, activate PKC, CK1 and PP2B, interfere with glutamate transmission |
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Term
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Definition
NEW GENERATION ANTIPSYCHOTIC'
Mechanism by 5-HT receptors - antagonist of 5-Ht, activate PLC, activate PKC, CK1 and PP2B, interfere with glutamate transmission |
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Term
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Definition
NEW GENERATION ANTIPSYCHOTIC
Mechanism by 5-HT receptors - antagonist of 5-Ht, activate PLC, activate PKC, CK1 and PP2B, interfere with glutamate transmission |
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Term
| PROMETHAZINE (PHENERGANL) |
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Definition
ANTIPSYCHOTIC
USE: antiemetic
Mechanism: blcosk H1 receptor blocker - antihistamine
- phenothiazine nucleaus |
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Term
| PROCHLORPERAZINE (COMPAZINE) |
|
Definition
ANTIPSYCHOTIC
USE: antiemetic
MechanismL D1 and D2 receptor blocker
-phenothiazine nucleus |
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Term
| ANTIEMETICS (ANTIPSYCHOTICS) |
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Definition
promethazine
prochlorperazine |
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Term
|
Definition
variety of metnal disorders
- disturbance of perception, impaired cognitive function
- schizo, dementias, bipolar |
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Term
|
Definition
to split the mind
- affects 1% with early onset and a life long progressive disease
- brain abnormality and NT imbalance
10% with a genetic factor
- can develop due to prenatal viral infections and revealed due to stress and changes in lifestyle |
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Term
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Definition
Positive: chronic psychotic condition characteried by marked disorganized thinking with loosely connected thoughts or hallucinations, false ideas or delusions, paranoid delusions, mood disturbances, condusion and suicidal thoughts
Negative: loss of normal function, social withdrawal, reduced speech and though, loss of enegy and inability to experience mental or physical pleasure |
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Term
| Etiolgoy of schizophrenia |
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Definition
1. biochemical abnormalities with increased dopamine receptors
2. structural abnormalities like enlarged ventricles, atrophy of cortical layers and decreased basal ganglia volume
3. functional abnormalities with reduced blood flow and decrease glucose used in prefrontal cortex
4. genetics |
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Term
| DOPAMINE HYPOTHESIS FOR SCHIZOPHRENIA |
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Definition
symptoms are due in part to the increase in activity of Dopaminergic neurons
- correlation of therapuetic potency and binding affinity as antagonist for dopamine receptors (D2), drugs enhancing dopamine tranmission can cause schizophrenic symptoms (l-DOpa, chronic amphetamines, apomorphine)
- D2 receptors are increased in brain sof schizophrenics |
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Term
| dorsal mesostriatial path (nigrostriatal) |
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Definition
| controls motor path - dopamine path |
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Term
| ventral mesostriatal (mesolimibic) |
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Definition
| dopamine path - controls behavior and emotion and increased in schizophrenia |
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Term
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Definition
| dopamine path - controls behavior and emotiona nd increase din schizophrenia |
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Term
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Definition
| dopamine path inhibiting prolactin secretion |
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Term
| Antipsychotic cholinergic muscarinic block |
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Definition
chlorpromazine and thioridazine
- dry mouth, urinary retention, memory impairment, blurred vision, constipation and confusion, increased HR |
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Term
| antipsychotic a-adrenoceptor block |
|
Definition
chlorpromazine
- orthostatic hypotension, light headed, reflex tachy, sex dysfunction |
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Term
| antipsychotic pituitary D2 receptor blcok |
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Definition
all but predominately haloperidol
- increase prolactin and lead to infertility and impotence |
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Term
| H1 histamine receptor block by antipsychotics |
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Definition
chlorpromazine and clozapine
- sedation and weight gain |
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Term
| Neuroleptic malignant syndrome |
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Definition
collapse of autonomics
- fever, daiphoresis, cardio instability
- 1-2% of patients and fatal in 10%
treat with BROMOCRIPTINE (D agonist) |
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Term
| Other Antipsychotic side effects |
|
Definition
1. cholinergice muscarine block
2. a-adrenoceptor block
3. H1 histamine block
4. pituitary D2 receptor block
5. nausea and vomiting
6. striatal dopamine receptor block - parkinsonia effects like tremor, bradykinesia, muscle rigidity and dystonias
7. dopamine receptor upregulation and supersensitivity after several month - tardive dyskinesia
8. increased drug metabolis, increase analgesia effect, anesthetics and CNS depressants, block efficacy of L-DOPA, decreased BP, seizure, coma, tachy |
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Term
|
Definition
| more selective for D2 receptors and high potential for extrapyramidal effects |
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Term
|
Definition
newer drugs
as/more pttent and selective for 5-HT receptors
some more effective at a lower dose and low incidence of extrapyramidal effects
no prolatcin elevation but high risk of agranulocytosis and weight gain |
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