Term
| prototype chemical convulsants |
|
Definition
| strychnine, picrotoxin, pentylenetratrazol |
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|
Term
| mech of action for chemical convulsants |
|
Definition
| dis-inhibition of inhibitory systems w/i the brain and spinal cord. |
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|
Term
|
Definition
| blocks postsynaptic inhibition produced by GLYCINE in the spinal cord |
|
|
Term
| presynaptic inhibition produced by GABA |
|
Definition
| picrotoxin and pentylenetretrazol |
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|
Term
| candidate for pharm treatment of learning and memory deficits in Down syndrome |
|
Definition
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|
Term
| commonly used in rodenticides |
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Definition
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|
Term
| toxic effects of strychnine |
|
Definition
| opisthotonic seizure (rigid arching of back) |
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|
Term
| treatment of stychnine poisoning |
|
Definition
IV admin. of diazepam
oral admin. of activated charcoal |
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|
Term
| prototype methylxanthines |
|
Definition
| caffeine, theophylline, and theobromine |
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|
Term
| effect of methylxanthines on CNS |
|
Definition
stimulation-study aid 80-250mg
increased cap for intellecual efford
decreased reaction time, fine motor, timing and math skills |
|
|
Term
|
Definition
high doses induce tachycardia
dilates peripheral vasculature
induces a constriction of cerebral blood vessels |
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|
Term
|
Definition
increased acid and pepsin
peristalsis-alleviates constipation |
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|
Term
| this effect occurs w/i normal dose range of methylx |
|
Definition
| antagonism of adenosine receptors |
|
|
Term
| what is the genetic variability of methylx due to |
|
Definition
| polymorphism of enzyme N-acetyltransferase |
|
|
Term
| drug half-life will be increased in |
|
Definition
hepatic dz
pregnant women
oral contraceptive |
|
|
Term
| drug half-life will be decreased |
|
Definition
smokers
phenytoin or barbiturates |
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|
Term
|
Definition
|
|
Term
|
Definition
nervousness
insomnia
delirium |
|
|
Term
| rapid IV fusion of methylx causes |
|
Definition
| sensory distortions- olfactory and gustatory |
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|
Term
|
Definition
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|
Term
|
Definition
| amphet, meth, cocaine, and methylphenidate |
|
|
Term
| which isomer of amphetamine is more potent on heart |
|
Definition
|
|
Term
| this psychostimulant produces little to no effect on the periphery |
|
Definition
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|
Term
| more potent enantiomer of amphetamine in CNS |
|
Definition
|
|
Term
| mech of action for psychostimulants |
|
Definition
| increased synaptic conc of dopamine, norep, and possibly serotonin |
|
|
Term
| amphetamine effect on monoamine trans |
|
Definition
| stimulation of released transmitters |
|
|
Term
| Cocaine and methylphenidate exception |
|
Definition
| they do NOT elicit monoamine release |
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|
Term
| pyschostimulants used in treatment of narcolepsy |
|
Definition
racemic amphetamine
d-amphetamine
methamphetamine |
|
|
Term
|
Definition
| weak affinity for dopamine reuptake transporters |
|
|
Term
| toxicity of pyschostimulants |
|
Definition
| true psychosis; misdiagnosed as schizophrenic reaction |
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|
Term
| chronic users of meth shows decreased binding of what |
|
Definition
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