Term
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Definition
-constant percentage of drug eliminated per unit time
-how most drugs are eiliminated |
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Term
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Definition
| time to reduce plasma levels by one half |
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Term
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Definition
| how many half lives does it take to reach a steady state? |
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Term
| capacity limited (zero order) elimination |
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Definition
-constant amount of drug eliminated per unit time
-can cause drug accumulation |
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Term
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Definition
| regulatory proteins that interact with a drug or hormone and initiate a cellular response |
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Term
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Definition
-dose that works in 50% of the population 50% of the time.
-threshold dose |
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Term
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Definition
| dose below which, no response |
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Term
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Definition
| half of possible maximum response |
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Term
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Definition
| does to produce 1/2 of the possible maximum response: ED50 |
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Term
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Definition
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Term
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Definition
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Term
| intrinsic activity (i.a.) |
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Definition
| ___________- the ability to produce a response |
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Term
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Definition
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Term
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Definition
| Agonists also have ________ and _________ |
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Term
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Definition
| how well the drug fits into binding sites |
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Term
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Definition
| how well the drug turns on the receptor after binding |
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Term
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Definition
| a partial agonist in the presence or a full agonist is an ___________ |
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Term
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Definition
| drugs that interact with a receptor to produce a response |
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Term
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Definition
| these can produce the full response I.A.= 1 |
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Term
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Definition
| these can produce a response less than that of full agonists. I.A> 0 and <1 |
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Term
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Definition
| these have affinity, no intrinsic activity, block the binding by an agonist to its receptor, blockade can be overcome, and reduce the potency of the agonist |
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Term
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Definition
| how well the drug turns on receptors |
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Term
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Definition
| how well a drug relieves symptoms |
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Term
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Definition
| what is the formula for the therapeutic index? |
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Term
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Definition
| What is the formula for the certain safety index? |
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Term
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Definition
| the difference between the therapeutic effect and the lethal effect. The further apart the curves are, the safer the drug. |
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Term
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Definition
| This tells you how far apart the tails of the curves are, the bigger the number, the safer the drug. |
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