Term
| What are the mediators of acute inflammation |
|
Definition
1. Histamine 2. 5-HT 3. Bradykinin 4. PG 5. LKT |
|
|
Term
| Which of the acute inflammatory mediators are the best vasodilators |
|
Definition
|
|
Term
| Which of the acute inflammation mediators is the best at preventing vacular permeability |
|
Definition
|
|
Term
| This acute inflammatory mediator causes pain |
|
Definition
|
|
Term
| What's the effect of IL-1, 2, 3 |
|
Definition
| Lymphocyte activation & PGE production |
|
|
Term
| What are the mediators of chronic inflammation |
|
Definition
IL-1, 2, 3
GM-CSF
TNF-a
Interferons
PDGF |
|
|
Term
|
Definition
| Macrophages and grunlocytes |
|
|
Term
| TNF-a increase the production of |
|
Definition
|
|
Term
| This chronic inflammatory mediator is a fibroblastic chemotaxis |
|
Definition
|
|
Term
|
Definition
1. Inhibit COX
2. Prevent formation of PG, TXA & Prostacyclin |
|
|
Term
| What's the rate limiting step in the formation of AA |
|
Definition
|
|
Term
| Are NSAID pain mediators? |
|
Definition
|
|
Term
| How are NSAIDs anti-inflammatory |
|
Definition
| Decrease vasodilator PG and this decreases edema |
|
|
Term
| How are NSAID a analgesic? |
|
Definition
| Decreases PG desensitizing nerve endings to bradykinin and 5-HT |
|
|
Term
| How do NSAID act as a Antipyretic |
|
Definition
| the cytokines cannot inflict a PG response |
|
|
Term
| How do NSAID work as an Antiplatelet |
|
Definition
| Induces reseresible inhibition of thromboxane synthesis |
|
|
Term
| What is the most common adverse reaction of NSAID |
|
Definition
| GI ulceration and renal injury |
|
|
Term
| How is Acetylsalicyclic acid eliminated? |
|
Definition
|
|
Term
| How is Acetylsalicylic acid metabolized? |
|
Definition
|
|
Term
| What is the MOA of aspirin |
|
Definition
| Binds irreversibly to COX |
|
|
Term
| Name the uses of Acetysalicylic acid |
|
Definition
Analgesia: Mild to moderate pain
Antipyretic
Anti-inflammatory
Prevent ischemic attacks, unstable angina |
|
|
Term
| What are the adverse effect of asprin |
|
Definition
Upper GI bleeding
Salicylism: vomiting, tinnitus, decrease hearing
Reyes syndrome |
|
|
Term
| This NSAID is used in gout |
|
Definition
|
|
Term
| What's the adverse reaction of Indomethacin |
|
Definition
| It's more toxic than aspirin |
|
|
Term
| What advantage does Ibuprofen have over aspirin? |
|
Definition
|
|
Term
| Name the 2 NSAIDs w/ Long half lives |
|
Definition
|
|
Term
| What advantage does Diclofenac have as an NSAID |
|
Definition
|
|
Term
| Which NSAID is used for Ocular |
|
Definition
|
|
Term
| Which NSAID is used for acute attacks and flare ups |
|
Definition
|
|
Term
| Name the Aniline derivative |
|
Definition
|
|
Term
| Does Acetaminophen have anti-inflammatory effects |
|
Definition
|
|
Term
| How is acetaminophen metabolized? |
|
Definition
|
|
Term
| What's the MOA of acetoaminophen |
|
Definition
| Might be due to the inhibition of CNS type of COX |
|
|
Term
| What are the uses for Acetaminophen |
|
Definition
| Analgesic and antipyretic |
|
|
Term
| What are the adverse reactions of acetaminophen |
|
Definition
Skin rash
Liver necrosis due to N-acetyl-p-benzoquinone |
|
|
Term
| What's the antidote for over dosing on acetaminophen |
|
Definition
|
|
Term
| Which COX is the enzyme that produces prostanoid mediator of inflammation |
|
Definition
|
|
Term
| _____ is a potent COX-2 inhibitor that is used in Osteoarhritis & rheumatoid arthritis |
|
Definition
|
|
Term
| What's an adverse effect of Celecoxib |
|
Definition
|
|
Term
| How do Golden salts treat rheumatoid arthritis |
|
Definition
| Might inhibit macrophage function |
|
|
Term
| when would you not use golden salts |
|
Definition
Pregnancy
Gold allergy
Impaired renal or liver |
|
|
Term
| What are some adverse reactions of golden salts |
|
Definition
Pruritic skin rash
Hematological ab.
Proteinuria
Peripheral neuropathy |
|
|
Term
| Golden salts are used when? |
|
Definition
Rheumatoid arthritis
Sjogren syndrome |
|
|
Term
|
Definition
Aurothiomalate
Aurothioglucose
Auranofin |
|
|
Term
| Which golden salt do you give PO |
|
Definition
|
|
Term
| Aurothiomalate and aurothioglucose are given how? |
|
Definition
|
|
Term
| What would you give w/ hydroxychloroquine for rheumatoid arthritis |
|
Definition
|
|
Term
| What are the adverse effects of Hydrooxychloroquine |
|
Definition
1. Ocular toxicity (irreversible)
2. Dyspepsia, nausea, ab pain |
|
|
Term
| How does hydroxychloroquine work for rheumatoid arthritis |
|
Definition
| Might act as a non-specific leukocyte function inhibitor |
|
|
Term
| Penicilliamine is a ______ of penicillin |
|
Definition
|
|
Term
| What's the MOA of Penicillamine? |
|
Definition
|
|
Term
| What are the major side effects of Penicillamine |
|
Definition
Decreases B6
Bone marrow depression |
|
|
Term
| When would you use Penicillamine for RA |
|
Definition
|
|
Term
| Name the two Immunosuppressive |
|
Definition
|
|
Term
| What's the MOA of Mehotrexate |
|
Definition
Potent immunosuppressive drug at anti-cancer doses
Dihydrofolase reductase inhibitor |
|
|
Term
| What are the adverse effects of Mehotrexate |
|
Definition
| Nausea, vomitting, rash, urticaria, renal damage |
|
|
Term
| What's the MOA of Azathioprine? When is it used? |
|
Definition
Inhibits DNA synthesis
Used in renal transplants |
|
|
Term
| What drugs are used for Anklosing Spondylitis |
|
Definition
Etanercept
Infliximab
Adalimumba
Abatacept |
|
|
Term
| Ethanercept is a recombinate protein made of what? |
|
Definition
|
|
Term
| When does Ethanercept peak? |
|
Definition
|
|
Term
| What's the MOA of Etanercept |
|
Definition
|
|
Term
| What are the adverse effects of Etanercept |
|
Definition
| Erythemia, local pain at the site of injection |
|
|
Term
| What kind of antibody is infliximab? |
|
Definition
|
|
Term
| Can you use Infliximab for RH |
|
Definition
| Yes, for those that do not respond to Infliximab |
|
|
Term
| What's the MOA of infliximab |
|
Definition
|
|
Term
| What's the adverse effect of Infliximab |
|
Definition
|
|
Term
| Adalimumba is what kind of antibody |
|
Definition
monoclonal
full IgG anti-TNF |
|
|
Term
| The clearance of Adalimumba is decreased by this drug |
|
Definition
|
|
Term
|
Definition
RA
Ankylosing spondylitis
Psoriati arthritis |
|
|
Term
| What are the adverse effects of Adalimumba |
|
Definition
Opportunistic infections
Rare luekopenia
Rare vasculitis |
|
|
Term
| What's the MOA of Abatacept |
|
Definition
1. Binds to CD80 & CD86
2. Inhibits activation of T cells by blocking B7-1 & B7-2 interaction w/ CD28 |
|
|
Term
| What condition is Abatacept used for? |
|
Definition
|
|
Term
| What's the adverse reactions of Abatacept |
|
Definition
Increase risk of URT
Anti-abaticpet antibodiy |
|
|
