Term
| Prostaglandin are formed from what precursor |
|
Definition
|
|
Term
| NSAIDs target ______ preventing what |
|
Definition
| Cyclooxygenase preventing Archidonic acid conversion to Prostaglandins |
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|
Term
| Name the function of PGE2 |
|
Definition
Vasodilator Fever inducer Cytoprotective |
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|
Term
| What is the function of PGI2 |
|
Definition
Vasodilator Platelet inhibitor |
|
|
Term
| What's the function of TXA2 |
|
Definition
Vasoconstrictor Platelet activator |
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|
Term
| What's the function of PGF2 a |
|
Definition
Contracts the uterus Lowers intraocular P |
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Term
|
Definition
|
|
Term
| What class of drug is Vioxx |
|
Definition
|
|
Term
| What's the problem w/ Vioxx |
|
Definition
| inhibits PGI2 and not TXA2 so it disinhibitis platelet aggregation form PGI2 and TXA2 just exaberates it |
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|
Term
| Prostaglandin & Thromboxane act as potent local _____ |
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Definition
|
|
Term
| cyclooxygenase is an enzyme used for the production of |
|
Definition
| Prostaglandins and Thromboxane |
|
|
Term
|
Definition
| Leukotriene from archnidonic acid |
|
|
Term
| Are leukotriene inhibited by COX inhibitors? |
|
Definition
|
|
Term
| leukotriene is synthesized by |
|
Definition
|
|
Term
| Prostagladins act on what kind of receptors |
|
Definition
|
|
Term
| PGE2 is removed from the body how? |
|
Definition
|
|
Term
| What enzymes are used to deactive PGE2 |
|
Definition
| PG reductase and 15 hydroxyl PG hydrogenase |
|
|
Term
| What's the inactive form of PGE2 |
|
Definition
|
|
Term
| when are PGD2, PGE2 and PGI2 produce in unusal circumstances |
|
Definition
PGD2 by Mastocytosis PGE2 by solid tumors w/ metastasis to bone PGI2 by pregnancy |
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Term
| What are the 8 clinical uses for Prostaglandins |
|
Definition
1. Penile dysfunction 2. Menstration 3. Induce labor 4. Termination of labor 5. Gastric secretion 6. Ductus Arteriosus 7. Pulmonary HTN 8. Glucoma |
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|
Term
| which prostaglandin is used to treat penile dysfunction |
|
Definition
|
|
Term
| What's the mechanism of action of PGE1 on penile dysfuction |
|
Definition
| Relaxes smooth muscle and dilators major arteries in the penis enchancing blood flow |
|
|
Term
| What are some side effects of treating penile dysfuction w/ PGE1 |
|
Definition
| Penile pain and prolonged erection |
|
|
Term
| Which two prostaglandins are used to stimulate menstration? |
|
Definition
|
|
Term
| What are the MOA of PGE2 and PGF2 on menstration |
|
Definition
| increases endometrial synthesis of PGE2 and PGF2 which contracts the uterus |
|
|
Term
| Which prostaglandin is used to induce labor? |
|
Definition
|
|
Term
| Which Prostaglandins are used to induce labor at any term |
|
Definition
|
|
Term
| Which type of Prostaglandins are used as protective agsinst gastric uclers produced by steriods and NSAIDs |
|
Definition
|
|
Term
| Prostaglandins stimulate the production of ___ in the stomach |
|
Definition
|
|
Term
| Why does the ductus arterioles remain open in premature deliveries |
|
Definition
| Due to the high production of prostaglandins |
|
|
Term
| Neonates w/ congenital heart disease depnd on ____ for survival |
|
Definition
|
|
Term
| What are the side effects of Alprostadil. What is it used for? |
|
Definition
Fever, flushing, bradycardia or tachycardia Used to maintain the patency of the ductus arteriosus |
|
|
Term
| Which Prostaglandin is used in Pulmonary HTN |
|
Definition
|
|
Term
| Epoprestenol increase cardiac ____ & ____ |
|
Definition
|
|
Term
| Epoprestenol decreases pulmonary _____ |
|
Definition
| pulmonary vascular resistance, total pulmonary resistance |
|
|
Term
| Which two Prostaglandins are used to treat Glaucoma |
|
Definition
|
|
Term
|
Definition
| Lower intraocular pressure due to the increase outflow of aqueous humor |
|
|
Term
|
Definition
Alprostadil Dinoprostone Epoprostenol Latanoprostol Misoprostol |
|
|
Term
| What effects does Alprostadil have? |
|
Definition
| Increase blood flow and oxygenation by vessel relaxation |
|
|
Term
| What are the uses of Alprostadil |
|
Definition
| Neonatal defects and Penile erection |
|
|
Term
| What's the MOA of Dinoprostone |
|
Definition
| Increase uterine contraction |
|
|
Term
| When would you use Dinoprostenol |
|
Definition
| Induction of labor and Abortion |
|
|
Term
| What is the effect of Epoprostenol and what is it used for |
|
Definition
Reduce platelet aggregation Peripheral vascular disease |
|
|
Term
| What's the effect of Latanprostol and it's use |
|
Definition
| Reduce intraocular pressure and is used to treat glaucoma |
|
|
Term
| Misoprostol is used to ____ ____ ____ ____ thus allowing _____ ____ to heal |
|
Definition
Suppress gastric acid secretion
gastric uclers |
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|
