Term
|
Definition
| Often precedes squamous cell carcinoma |
|
|
Term
|
Definition
| Primary adrenocortical deficiency |
|
|
Term
|
Definition
| Polyostotic fibrous dysplasia, precocious poo-berty, cafe-au-lait spots, short stature, young girls |
|
|
Term
|
Definition
| Hereditary nephritis with nerve deafness |
|
|
Term
| Anti-basement membrane antibodies |
|
Definition
|
|
Term
| Anticentromere antibodies |
|
Definition
|
|
Term
| Anti-double-stranded DNA antibodies (ANA antibodies) |
|
Definition
| SLE (type III hypersensitivity) |
|
|
Term
| Anti-epithelial cell antibodies |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Antimitochondrial antibodies |
|
Definition
| Primary biliary cirrhosis |
|
|
Term
| Antineutrophil antibodies |
|
Definition
|
|
Term
|
Definition
| Idiopathic thrombocytopenic purpura |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Arnold-Chiari malformation |
|
Definition
| Cerebellar tonsillar herniation |
|
|
Term
|
Definition
|
|
Term
| Atrophy of the mammillary bodies |
|
Definition
| Wernicke's encephalopathy |
|
|
Term
|
Definition
| Acute myelogenous leukemia (especially the promyelocytic type) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Basophilic stippling of RBCs |
|
Definition
|
|
Term
| Becker's muscular dystrophy |
|
Definition
| Defective dystrophin; less severe than Duchenne's |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Multiple myeloma (kappa or lambda Ig light chains in urine), Waldenstrom's macroglobulinemia (IgM) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Defect in platelet adhesion |
|
|
Term
| Bilateral hilar adenopathy, uveitis |
|
Definition
|
|
Term
|
Definition
| Histiocytosis X (eosinophilic granuloma) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Fibrocystic change of the breast |
|
|
Term
|
Definition
|
|
Term
| Boot-shaped heart on x-ray |
|
Definition
|
|
Term
|
Definition
| Osteoarthritis (PIP swelling secondary to osteophytes) |
|
|
Term
|
Definition
|
|
Term
| Branching rods in oral infection |
|
Definition
|
|
Term
|
Definition
Hemorrhage causes brown color of osteolytic cysts:
1. Hyperparathyroidism
2. Osteitis fibrosa cystica (von Recklinghausen's disease) |
|
|
Term
|
Definition
| X-linked agammaglobulinemia |
|
|
Term
|
Definition
| Posthepatic venous thrombosis |
|
|
Term
|
Definition
| Small/medium-artery vasculitis |
|
|
Term
|
Definition
| 8:14 translocation; associated with EBV; "starry sky" appearance on histology |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Wegener's granulomatosis, microscopic polyangiitis |
|
|
Term
| Cafe-au-lait spots on skin |
|
Definition
|
|
Term
|
Definition
| Duchenne's muscular dystrophy |
|
|
Term
|
Definition
| Granulosa-theca cell tumor of the ovary |
|
|
Term
| Cardiomegaly with apical atrophy |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Primary syphilis (not painful) |
|
|
Term
|
Definition
| Haemophilus ducreyi (painful) |
|
|
Term
|
Definition
| Multiple sclerosis (nystagmus, intention tremor, scanning speech), cholangitis (jaundice, RUQ pain, fever) |
|
|
Term
|
Definition
| Bronchial asthma (eosinophil membranes) |
|
|
Term
|
Definition
|
|
Term
| Cherry-red spot on macula |
|
Definition
| Tay-Sachs and Niemann-Pick disease |
|
|
Term
| Cheyne-Stokes respirations |
|
Definition
| Central apnea in CHF and increased intracranial pressure |
|
|
Term
|
Definition
| Endometriosis (frequently involves both ovaries) |
|
|
Term
| Chronic atrophic gastritis |
|
Definition
| Predisposition to gastric carcinoma |
|
|
Term
|
Definition
| Hypocalcemia (facial muscle spasm upon tapping) |
|
|
Term
| Clear cell adenocarcinoma of the vagina |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Codman's triangle on x-ray |
|
Definition
|
|
Term
|
Definition
| Mycoplasma pneumoniae, infectious mononucleosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Continuous machinery murmur |
|
Definition
|
|
Term
|
Definition
| Debranching enzyme deficiency |
|
|
Term
| Cough, conjunctivitis, coryza + fever |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Crescents in Bowman's capsule |
|
Definition
| Rapidly progressive crescentic glomerulonephritis |
|
|
Term
|
Definition
| Congenital unconjugated hyperbilirubinemia |
|
|
Term
|
Definition
| Acute gastric ulcer associated with severe burns |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Bronchial asthma (whorled mucous plugs) |
|
|
Term
|
Definition
| Acute gastric ulcer associated with CNS injury |
|
|
Term
|
Definition
|
|
Term
| Depigmentation of neurons in substantia nigra |
|
Definition
| Parkinson's disease (basal ganglia disorder-rigidity, resting tremor, bradykinesia) |
|
|
Term
| Dermatitis, dementia, diarrhea |
|
Definition
| Pellagra (niacin, vitamin B3 deficiency) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Post-MI fibrinous pericarditis |
|
|
Term
|
Definition
| Post-MI fibrinous pericarditis |
|
|
Term
|
Definition
| Congenital conjugated hyperbilirubinemia (black liver) |
|
|
Term
| Duchenne's muscular dystrophy |
|
Definition
| Deleted dystrophin gene (X-linked recessive) |
|
|
Term
|
Definition
| Osteoarthritis (polished, ivory-like appearance of bone) |
|
|
Term
|
Definition
| Trisomy 18 associated with rocker-bottom feet, low-set ears, heart disease |
|
|
Term
|
Definition
| Late cyanosis shunt (uncorrected L --> R shunt becomes R --> L shunt) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Superior trunk (C5-C6) brachial plexus injury ("waiter's tip") |
|
|
Term
| Erythema chronicum migrans |
|
Definition
|
|
Term
|
Definition
| Genetically inherited aplastic anemia |
|
|
Term
|
Definition
| Proximal tubular reabsorption defect |
|
|
Term
| "Fat, female, forty, and fertile" |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Colon polyps with osteomas and soft tissue tumors |
|
|
Term
|
Definition
| Glucocerebrosidase deficiency |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Benign congenital unconjugated hyperbilirubinemia |
|
|
Term
| Glanzmann's thrombasthenia |
|
Definition
| Defect in platelet aggregation |
|
|
Term
|
Definition
| Autoantibodies against alveolar and glomerular basement membrane proteins |
|
|
Term
|
Definition
| Duchenne's (use of patient's arms to help legs pick self off the floor) |
|
|
Term
|
Definition
|
|
Term
| "Hair-on-end" (crew-cut) appearance on x-ray |
|
Definition
| B-thalassemia, sickle cell anemia (extramedullary hematopoiesis) |
|
|
Term
| Hand-Schuller-Christian disease |
|
Definition
| Chronic progressive histiocytosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Choriocarcinoma, hydatidiform mole (occurs with and without embryo) |
|
|
Term
|
Definition
| Osteoarthritis (DIP swelling secondary to osteophytes) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Hypersensitivity vasculitis associated with hemorrhagic urticaria and URIs |
|
|
Term
|
Definition
| Infections mononucleosis (EBV) |
|
|
Term
| High-output cardiac failure (dilated cardiomyopathy) |
|
Definition
| Wet beriberi (thiamine, vitamin B1 deficiency) |
|
|
Term
|
Definition
| Reiter's syndrome, ankylosing spondylitis |
|
|
Term
|
Definition
| Diabetes mellitus type 1 (caused by autoimmune destruction of Beta cells) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Ptosis, miosis, and anhidrosis |
|
|
Term
|
Definition
| Splenectomy (or nonfunctional spleen) |
|
|
Term
|
Definition
| Caudate degeneration (autosomal dominant) |
|
|
Term
| Hyperphagia + hypersexuality + hyperorality + hyperdocility |
|
Definition
| Kluver-Bucy syndrome (amygdala) |
|
|
Term
| Hyperpigmentation of skin |
|
Definition
| Primary adrenal insufficiency (Addison's disease) |
|
|
Term
| Hypersegmented neutrophils |
|
Definition
|
|
Term
| Hypertension + hypokalemia |
|
Definition
|
|
Term
|
Definition
| Esophageal webs with iron deficiency anemia |
|
|
Term
|
Definition
| Gout (MP joint of hallux) |
|
|
Term
|
Definition
| Iron deficiency anemia, lead poisoning |
|
|
Term
| Increased alpha-fetoprotein in amniotic fluid/maternal serum |
|
Definition
| Anencephaly, spina bifida (neural tube defects) |
|
|
Term
| Increased uric acid levels |
|
Definition
| Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics |
|
|
Term
|
Definition
|
|
Term
| Jarisch-Herheimer reaction |
|
Definition
| Syphilis -- overaggressive treatment of an asymptomatic patient that causes symptoms due to rapid lysis |
|
|
Term
|
Definition
| Neutrophil chemotaxis abnormality |
|
|
Term
|
Definition
| AIDS in MSM (men who have sex with men) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Kimmelstiel-Wilson nodules |
|
Definition
|
|
Term
|
Definition
| Bilateral amygdala lesions |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Gastric adenocarcinoma with ovarian metastases |
|
|
Term
|
Definition
|
|
Term
| Lens dislocation + aortic dissection + joint hyperflexibility |
|
Definition
| Marfan's syndrome (fibrillin deficit) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Endocarditis associated with SLE |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Neurofibromatosis (von Recklinghausen's disease) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| "Lumpy-bumpy" appearance of glomeruli on immunofluorescence |
|
Definition
| Poststreptococcal glomerulonephritis |
|
|
Term
| Lytic bone lesions on x-ray |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Esophagogastric lacerations |
|
|
Term
|
Definition
| Muscle phosphorylase deficiency |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Monoclonal antibody spike |
|
Definition
| Multiple myeloma (called the M protein; usually IgG or IgA), MGUS (monoclonal gammopathy of undetermined significance), Waldenstrom's (M protein = IgM) macroglobulinemia |
|
|
Term
|
Definition
|
|
Term
| Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis |
|
Definition
| Wegener's and Goodpastoooor's (hemoptysis and glomerular disease) |
|
|
Term
| Needle-shaped, negatively birefringent crystals |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Nephritis + cataracts + hearing loss |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Sphingomyelinase deficiency |
|
|
Term
|
Definition
| Sheehan's syndrome (pituitary infarction) |
|
|
Term
|
Definition
|
|
Term
| Occupational exposure to asbestos |
|
Definition
|
|
Term
|
Definition
| Papillary carcinoma of the thyroid |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Paget's disease of bone (osteitis deformans) |
|
Definition
| Increased osteoblastic and osteoclastic activity |
|
|
Term
|
Definition
|
|
Term
| Palpable purpura on legs and buttocks |
|
Definition
|
|
Term
|
Definition
| Bronchogenic apical tumor associated with Horner's disease |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Nigrostriatal dopamine depletion |
|
|
Term
| Periosteal elevation on x-ray |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Philadelphia chromosome (bcr-abl) |
|
Definition
| CML (may sometimes be associated with AML) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Progressive dementia, similar to Alzheimer's |
|
|
Term
|
Definition
| Emphysema (centroacinar [smoking], panacinar [alpha1-antitrypsin deficiency]) |
|
|
Term
|
Definition
| Esophageal webs with iron deficiency anemia |
|
|
Term
|
Definition
| Gout (MP joint of hallux) |
|
|
Term
|
Definition
|
|
Term
| Polyneuropathy, cardiac pathology, and edema |
|
Definition
| Wet beriberi (vitamin B1 deficiency) |
|
|
Term
| Polyneropathy preceded by GI or respiratory infection |
|
Definition
|
|
Term
|
Definition
| Lysosomal glucosidase deficiency associated with cardiomegaly |
|
|
Term
|
Definition
|
|
Term
| Positive anterior "drawer sign" |
|
Definition
| Anterior cruciate ligament injury |
|
|
Term
|
Definition
|
|
Term
| Pseudopalisade tumor cell arrangement |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Ptosis, miosis, anhidrosis |
|
Definition
| Horner's syndrome (Pancoast's tumor) |
|
|
Term
|
Definition
| Seondary syphilis, Rocky Mountain spotted fever |
|
|
Term
|
Definition
| Recurrent vasospasm in extremities |
|
|
Term
|
Definition
|
|
Term
| Recurrent pulmonary Pseudomonas and S. aureus infections |
|
Definition
|
|
Term
|
Definition
| Paroxysmal nocturnal hemoglobinuria |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Urethritis, conjunctivitis, arthritis |
|
|
Term
| Renal cell carcinoma + cavernous hemangiomas + adenomas |
|
Definition
| von Hippel-Lindau disease |
|
|
Term
| Renal epithelial casts in urine |
|
Definition
| Acute toxic/viral nephrosis |
|
|
Term
| Rhomboid crystals, positively birefringent |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Congenital conjugated hyperbilirubinemia |
|
|
Term
| Rouleaux formation (RBCs) |
|
Definition
|
|
Term
|
Definition
| Left-to-right shunt (VSD, PDA, ASD), mitral regurgitation, LV failure (CHF) |
|
|
Term
|
Definition
| Aortic stenosis, hypertrophic subaortic stenosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Cutaneous T-cell lymphoma |
|
|
Term
|
Definition
| Postpartum pituitary necrosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Dry eyes, dry mouth, arthritis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Erythema infectiosum (fifth disease) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Membranous glomerulonephritis |
|
|
Term
|
Definition
|
|
Term
| Splinter hemorrhages in fingernails |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Subepithelial humps on EM |
|
Definition
| Poststreptococcal glomerulonephritis |
|
|
Term
| Suboccipital lymphadenopathy |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Swollen gums, bruising, poor wound healing, anemia |
|
Definition
| Scurvy (ascorbic acid, vitamin C deficiency) -- vitamin C is necessary for hydroxylation of proline and lysine in collagen synthesis |
|
|
Term
| Systolic ejection murmur (crescendo-decrescendo) |
|
Definition
|
|
Term
|
Definition
| Burkitt's lymphoma (c-myc activation) |
|
|
Term
|
Definition
| Follicular lymphomas (bcl-2 activation) |
|
|
Term
|
Definition
|
|
Term
| Tendon xanthomas (classically Achilles) |
|
Definition
| Familial hypercholesterolemia |
|
|
Term
| Thumb sign on lateral x-ray |
|
Definition
| Epiglottis (Haemophilus influenzae) |
|
|
Term
|
Definition
| Chronic bacterial pylonephritis |
|
|
Term
|
Definition
|
|
Term
| "Tram-track" appearance on LM |
|
Definition
| Membranoproliferative glomerulonephritis |
|
|
Term
|
Definition
|
|
Term
| "Tram-track" appearance on LM |
|
Definition
| Membranoproliferative glomerulonephritis |
|
|
Term
|
Definition
| Visceral cancer, pancreatic adenocarcinoma (migratory thrombophlebitis), hypocalcemia (carpal spasm) |
|
|
Term
|
Definition
| Left supraclavicular node enlargement from metastatic carcinoma of the stomach |
|
|
Term
|
Definition
| Pulmonary embolism (triad = blood stasis, endothelial damage, hypercoagulation) |
|
|
Term
| von Recklinghausen's disease of bone |
|
Definition
| Osteitis fibrosa cystica ("brown tumor") |
|
|
Term
| Waterhouse-Friderichsen syndrome |
|
Definition
| Adrenal hemorrhage associated with meningococcemia |
|
|
Term
|
Definition
| Chronic end-stage renal disease |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Malabsorption syndrome caused by Tropheryma whippelii |
|
|
Term
|
Definition
| Hepatolenticular degeneration |
|
|
Term
| "Wire loop" appearance on LM |
|
Definition
|
|
Term
| "Worst headache of my life" |
|
Definition
| Berry aneurysm- associated with adult polycystic kidney disease |
|
|
Term
|
Definition
|
|
Term
| Xerostomia + arthritis + keratoconjunctivities sicca |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Zollinger-Ellison syndrome |
|
Definition
| Gastrin-secreting tumor associated with ulcers |
|
|
