Term
| What are the 3 major phases of wound healing? |
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Definition
| 1. Inflammation 2. Proliferation 3. Re-epithelialization |
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Term
| What happens in the Inflammation phase of wound healing? |
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Definition
| 1. Platelets accumulate and form a clot. 2.Fibrin and serum proteins are trapped, and growth factors form. 3. Neutrophils go to the area for debridement and act as an antibacterial agent. 4. Monocytes continue with debridgement. 5. Mast cells release cytokines and express proteinases to clean up. |
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Term
| What happens during the proliferation phase of wound healing? |
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Definition
| 1. Granulation tissue forms. 2. Fibroblasts, endothelial cells and macrophages travel to the area. 3. Fibroblas production occurs to make collagen and elastin. 4. Tissue contracts and closes in. 5. There is new formation of blood vessels to the area. |
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Term
| What happens during the re-epithelialization phase of wound healing? |
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Definition
| 1. Collagen is broken down. 2. Keratinocytes migrate from the wound edges. 3. CT-degrading enzymes are released. 4. Granulation tissue is rapidly covered. |
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Term
| In what stage of healing will you see granulation tissue form? What does it look like? |
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Definition
| In the proliferation stage. It looks cobbled, and is a beefy red color. |
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Term
| How long after injury does proliferation start? |
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Definition
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Term
| How long does proliferation last? |
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Definition
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Term
| What are the local factors that can impede wound healing? (5) |
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Definition
| 1. Eschar and dessication. 2. Foreign bodies/infection. 3. Necrotic tissue. 4. Debris 5. Sutures |
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Term
| What systemic factors can impede wound healing? (4) |
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Definition
| 1. Stress 2. Obesity 3. Nutrition 4. Temperature |
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Term
| What comorbidities can impede wound healing? (5) |
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Definition
| 1. Diabetes 2. Immunodeficiency 3. Cancer 4. Peripheral vascular disease 5. Age |
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