Term
| atropine and most of these are tertiary amine meaning they they are well absorbed in : gut, conjunctiva, possibly skin, and can go to CNS |
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Definition
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Term
| Muscarinic antagonist that is quaternary amine, therefore does not go in CNS and is developed for more peripheral applications like asthma |
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Definition
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Term
| Antimuscarinic agents like atropine are _____ at muscarinic receptors |
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Definition
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Term
| Tissues most sensitive to atropine |
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Definition
| salivary, bronchial, sweat |
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Term
| tissues least sensitive to atropine |
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Definition
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Term
| atropine is a _____ antagonist |
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Definition
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Term
| pirezepine is 5x more selective for ____ receptors than ___ receptors |
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Definition
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Term
| sweat glands have predominant tone of |
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Definition
| Sympathetic (cholinergic) |
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Term
| genital tract has predomoninant tone of |
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Definition
| Sympathetic and Parasympathetic |
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Term
| side effects of antimuscarinics in CNS |
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Definition
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Term
| at toxic doses ___ and to lesser extent atropine can cause excitment, agitation, hallucinations, and coma |
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Definition
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Term
| Antimuscarinics useful in tremor associated w/ ______ because they decrease cholinergic activity in basal ganglia and striatum |
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Definition
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Term
| can precipitate acute glaucoma in a patietn w/ narrow anterior chamber angle |
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Definition
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Term
| high doess of atropine to heart cause |
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Definition
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Term
| low doses of atropine to heart cause |
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Definition
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Term
| mechanism by which low doses of atropine cause bradycardia by increasing ACH release (vagal) |
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Definition
| blocking of autoreceptors |
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Term
| Blockade of this receptor has no clinical significance except in ATRIAL FLUTTER OR FIBRILLATION |
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Definition
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Term
| PS has little effect on ventricles , mostly on |
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Definition
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Term
| antimuscarnicis usually cause tachycardia on heart and ____ in blood pressure |
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Definition
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Term
| Useful for blocking or reversing effects of cholinergic excess in CV system |
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Definition
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Term
| use of muscarinic antagonists on respiratory system not as good as w/ B adrenergic agnoists and limited to |
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Definition
| inhalation anestheisa to reduce secretions and prevent laryngospasm |
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Term
| seretio nof acid, pepsin, and mucin are reduced but only at ____ doses of antagonist |
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Definition
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Term
no significant effects on uterus
useful for treating spasms
may worsen urinary retention |
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Definition
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Term
elevation of body temperature in infatnts and chilren is known as this:
occurs by blocking *sympathetic* stimulation of sweat glands (M2, M3) |
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Definition
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Term
| can be used to treat parkinsons or drug induced extrapyramidal syndromes |
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Definition
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Term
| Can be used to treat parkinsons, and is cogener of benadryl also used for mm pain |
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Definition
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Term
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Definition
| Benztropine, Biperiden, Orphenadrine, Trihexyphenidyl |
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Term
| If you want midraiasis w/ no cyclopelgia dont use antimuscarinic use... |
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Definition
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Term
Opthalmological disorders:
3-7 days action |
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Definition
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|
Term
Opthalmological disorders:
7-10 days action |
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Definition
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|
Term
Opthalmological disorders:
1-3 days |
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Definition
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Term
Opthalmological disorders:
1 day action |
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Definition
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|
Term
Opthalmological disorders:
.25 day |
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Definition
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Term
| Can be combined w/ sympathomimetic (hydroxyamphetamine) good for short term mydriasis |
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Definition
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Term
| Old school drugs to reduce airway secretions, laryngospasm by irritant anesthetics |
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Definition
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Term
antimuscarinic asthma treatment blocks vagal activation of muscarinic receptors
also COPD |
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Definition
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Term
| combines bronchodilator effects of muscarinic block and adrenergic stimulation |
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Definition
| Ipratropium and albuterol (Combivent) |
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Term
| Besides Ipratropium this is an antimuscarinic used for treatment of asthma/COPD |
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Definition
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Term
Reflex vagal discharge from pain of MI leads to brady cardia
also intraoperatively vagal reflexes can be stimulated this is indicated for thse two conditions though the amount needs to be just right... if too little can make worse |
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Definition
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|
Term
| reduce gastric emptying thus can exacerbate eptic ulcers despite reducing gastric secretions |
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Definition
|
|
Term
| Clinical use for peptic ulcers |
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Definition
| Atropine, Hyoscyamine, Glycopyrrolate |
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Term
| added to diphenoxylate to discourage use of opiate in antidiarrheal |
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Definition
|
|
Term
|
Definition
| atropine and diphenoxylate |
|
|
Term
| treats irritable bowel syndrome and spastic colon Dicyclomine and _____ |
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Definition
|
|
Term
| treats irritable bowel syndrome and spastic colin Hyoscyamine and ____ |
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Definition
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|
Term
| antimuscarinic to reduce bladder spasms and treat urge incontiance |
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Definition
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|
Term
antimuscarinic to reduce bladder spasms and treat urge incontiance
includes Oxybutynin, Tolterodine and____ |
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Definition
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|
Term
antimuscarinic to reduce bladder spasms and treat urge incontiance
includes Oxybutynin, Fesoterodine and____ |
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Definition
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|
Term
| M3 selective antimuscarnics can be better for over active bladder they include Darifenacin (enablex) and ____ |
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Definition
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|
Term
| M3 selective antimuscarnics can be better for over active bladder they include Solifenacin (Vesicare) and ____ |
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Definition
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Term
| anti-cholinestearase pesticides + wildmushrooms can cause cholinergic crisis treat w/ tertiary antimuscarnic such as |
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Definition
|
|
Term
| Pralidoximen (PAM) helps regenerate cholinesterase but does not cross blood brain barrier and will not regenerate |
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Definition
|
|
Term
| rapid onset mushroom poisoning (15-30 min after) caused by |
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Definition
|
|
Term
| deslayed onset mushroom poisoning is due to mushrooms that damage liver and kidney most likely due to |
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Definition
|
|
Term
| Atropine is only useful in treating this type of musrhoom poisoning |
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Definition
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|
Term
| effect of muscarniic agonists on CV in therapuetic dosages |
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Definition
| bradycardia followed by tachycardia |
|
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Term
| often symptomatic maintenance is only treatment needed for muscarnic antagonist overdose however if enough cholinesterase inhibition then treat with |
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Definition
|
|
Term
| atropine is a very safe drug but is contradited in patients w/ |
|
Definition
glaucoma (particuarly narrow angle closure) and can precipiate acute glaucoma
males w/ prostatic hyperplasia (precipitates urinary retention) |
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Term
| only ganglionic blocker available |
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Definition
|
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Term
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Definition
|
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Term
| besides mecamylamine (cns) other ganglionic blockers (non cns) |
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Definition
| TEA, hexamethonium, trimethaphan |
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Term
| orphan drug by FDA for Tourettes |
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Definition
|
|
Term
| useful for lowering blood pressure in emergency cases of acute dissecting aortic aneurysm |
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Definition
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