Term
| cross linking of DNA between DNA strands or base pairs, cell cycle non specific, different toxicity profiles |
|
Definition
|
|
Term
| Cyclophosphamides, ifosfamide, melphalan, bendamustine, chlorambucil |
|
Definition
|
|
Term
| Cisplatin, Carboplatin, Oxaliplatin |
|
Definition
|
|
Term
| Inhibition of topoisomerases --> prevention of strand resealing |
|
Definition
|
|
Term
| Daunorubicin, epirubicin, valrubicin |
|
Definition
|
|
Term
| Anthracyclines, Epidophyllotoxins, Mixtoxantrone |
|
Definition
| Topoisomerase II inhibitors |
|
|
Term
|
Definition
|
|
Term
| Topoisomerase II inhibition, intercalation between base pairs, free radical formation, cell cycle non specific |
|
Definition
| Daunorubicin, epirubicin, valrubicin |
|
|
Term
| topoisomerase II inhibition, cell cycle specific G2 phase |
|
Definition
|
|
Term
|
Definition
| Topoisomerase I inhibitors |
|
|
Term
|
Definition
|
|
Term
| Prevent microtubule formation, cell cycle specific for M phase |
|
Definition
|
|
Term
| vincristine, vinblastine, vindesine |
|
Definition
|
|
Term
| paclitaxel, docetaxel,cabazitaxel |
|
Definition
|
|
Term
|
Definition
| Vinca Alkaloids, Taxanes, Eribulin, and Exabepilone |
|
|
Term
| Fludabarine, thoguanine, cladribine, clofarabine, mecaptopurine, pentostain |
|
Definition
|
|
Term
| Purine analogues, Pyrimidine analogues |
|
Definition
|
|
Term
| Incorporated directly into DNA (replace adenine, guanine) cell cycle specific S phase |
|
Definition
| fludabarine, thoguanine, cladribine, clofarabine, mercatopurine,pentostain |
|
|
Term
| Cytarbine, fluouracil, capecitabine, gemcitabine |
|
Definition
|
|
Term
| resemble pyrimidine base cytosine-- incorporated directly into DNA and inhibit DNA synthesis, and DNA polymerase |
|
Definition
| Cytarabine and gemcitabine |
|
|
Term
| given as Bolus RNA related effects, given as infusion DNA related effects |
|
Definition
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|
Term
| resemble pyrimidine bases uracil and thymine, multiple mechanisms |
|
Definition
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|
Term
| Major drug interaction between 6-MP and allopurinol |
|
Definition
|
|
Term
| methotrexate, premetrexed, pralatrexate |
|
Definition
|
|
Term
| cell cycle specific S phase, inhibition of dihydrofolate reductase FH2-->FH4 via DHFR |
|
Definition
| methotrexate, pemetrexed, pralatrexate |
|
|
Term
| Drug interaction with NSAIDS, significant decreased clearance of MTX |
|
Definition
|
|
Term
|
Definition
|
|
Term
| cell cycle specific for G2 phase, generation of free radicals |
|
Definition
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|
Term
| Intravesicular instillation (put into bladder, let it roll around, suck it out) for bladder cancer; max effect in late G and early S phases |
|
Definition
|
|
Term
| Selective estrogen receptor modifiers (competitively binds estrogen receptors) |
|
Definition
|
|
Term
|
Definition
| anastrozole, letrozole, exemestane |
|
|
Term
|
Definition
|
|
Term
|
Definition
| bicalutamide, flutamide, nilutamide, abiraterone, enzalutamide |
|
|
Term
| Rituximab, trastuzumab, bevacizumab,cetuximab, alemtuzumab, brentuximab, ipilmumab, ofatumumab, pantitumumab |
|
Definition
|
|
Term
| Recognizes CD20 antigen on cancerous B cells, most commonly, non-hodgkins lymphoma, serious infusion related rxns |
|
Definition
|
|
Term
| binds+ tumor cells and flags them for destruction by immune system to HER2 |
|
Definition
|
|
Term
| Binds vascular endothelial growth factor inhibiting tumor angiogenesis |
|
Definition
|
|
Term
| Binds epidermal growth factor receptor (EGFR) |
|
Definition
|
|
Term
| Used for metastatic prostatic cancer-- process where you can take own APC cells out, get modified to stimulate T cells, then reinfused to have T cell attack prostate cancer |
|
Definition
|
|
Term
| Stops phosphorylation and cell signaling that would result in tumor survival and proliferation and result in apoptosis and G1 arrest |
|
Definition
| Tyrosine Kinase Inhibitors |
|
|
Term
| BRAF kinase inhibitor -- oral agent |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Hedgehog pathway inhibitor |
|
Definition
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