Term
|
Definition
| nitrogen mustards, platinum analogs; MOA: cross linking DNA or base pairs, cell cycle non-spec. |
|
|
Term
|
Definition
| cyclophosphamides, ifosfamide, melphalan, bendamustine, chlorambucil |
|
|
Term
|
Definition
| cisplatin (platinol), carboplatin (paraplatin), oxaliplatin (eloxatin) |
|
|
Term
|
Definition
| neuropathy; cold sensitivity, pharyngo-laryngeal dysthesia |
|
|
Term
| myelosupression of platinums |
|
Definition
| carboplatin= thrombocytopenia, cisplatin= anemia |
|
|
Term
|
Definition
| nitrosureas, ethylenines, alkyl sulfonates, triazenes |
|
|
Term
|
Definition
| type I and II toperisomerase inhibitors, |
|
|
Term
| topoisomerase II inhibitors (cell cycle non-specific) |
|
Definition
| anthracyclines; daunorubacin, doxorubaci, epirubacin, valrubicin |
|
|
Term
| topoisomerase II inhibitors (G-phase specific) |
|
Definition
| epidophyllotoxins; etoposide, teniposide |
|
|
Term
| myelosuppression-pancytopenia |
|
Definition
| topo I (irinotecan, topotecan) topo II (rubacins, etoposide and teniposide), folate antagonists, |
|
|
Term
|
Definition
| drug to protect against cardiotoxicity and vesicant effects seen in rubacin administration; iron chelator that binds free radicals |
|
|
Term
| non-specific cell cycle inhibitors |
|
Definition
| nitrogen mustards, platinum agents, anthracyclines (rubacin/topo II inhib) |
|
|
Term
| S phase specific cell cycle inhibitors |
|
Definition
| topo I inhibitors (irinotecan, topotecan), purine analogues, pyrimidine analogs, folate analogues |
|
|
Term
| m phase specific cell cycle inhibitors |
|
Definition
| vinka alkaloids, taxanse, eribulin, exabepilone |
|
|
Term
| G phase specific cell cycle inhibitors |
|
Definition
| topo II ihibitors (etoposide, teniposide) and bleomycin |
|
|
Term
|
Definition
| diarrhea, acute; use atropine, delayed; use loperamide |
|
|
Term
|
Definition
| cladribine, clofarabine, fludabarine, pentostain, thoguanine, mercaptopurine (6-MP) |
|
|
Term
|
Definition
| capecitabine, cytarbine, gencetabin, fluoruracil (5-FU) |
|
|
Term
|
Definition
| methotrexate, pralatrexate, premetrexed |
|
|
Term
|
Definition
| mucosal damage, nephrotoxicity, pancytopenia, |
|
|
Term
|
Definition
| drug to decrease or prevent methotrexate toxicity |
|
|
Term
|
Definition
| vincristine,vindesine, vinblastine, vinorelbine |
|
|
Term
|
Definition
| mylosuppression (vinorelbine, vinblastine), vesicant, fatal if intrathecal admin, neurotoxicity, dose adjust for hepatic |
|
|
Term
| topoisomerase I inhibitors |
|
Definition
| canptotheicins; irinotecan, topotecan |
|
|
Term
|
Definition
| paclitaxel, docetaxel, cabazitaxel |
|
|
Term
|
Definition
| infusion HS caused by crephor; premedicate with H2, H1, steroid |
|
|
