Term
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Definition
| Vinca alkaloid.. ..M phase (microtubules).. ..testicular, hodgkins |
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Term
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Definition
| Vinca alkaloid.. ..M phase (microtubules).. ..MOPP hodgkins...less mylosupression but periph neuropathy |
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Term
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Definition
| semisynthetic vinca alkyloid...non-small cell lung cancer |
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Term
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Definition
| child ALL....structure like vinblastine |
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Term
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Definition
| vinblastine, vincristine, vinorelbine, vindesine....block microtubule polymerization Mitosis (m phase) |
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Term
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Definition
| paclitaxel, docetaxel...m phase....depol. of microtubules...ovarian/breast...(PGP MDR) |
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Term
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Definition
| anthracycline anolauge binds to double helix of proliferating cells...rhabdomyosarcoma and whilms tumor |
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Term
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Definition
doxirubicin - solid tumors
daunirubicin - leukemias
cardiomyopathy, DNA intercalation, ROS |
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Term
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Definition
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Term
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Definition
| DNA binding - dec blood calcium |
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Term
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Definition
| actinomycin, doxirubicin, idarubacin, plicamycin |
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Term
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Definition
| G2 phase selective, testicular cancer, breaks DNA via iron dependant free radicals, ....hyperpigmentation, pulminary fibrosis....resistance via bleomycin amylase |
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Term
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Definition
| alkylating...not cell cycle specific, stomach, cervical, breast... radiosensitizer |
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Term
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Definition
| dec asp in cells (esp ALL) .... pegasparginase for allergic ppl |
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Term
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Definition
| S phase, lung/testicular cancer ... breaks DNA via inhibition of topoisomerase II |
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Term
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Definition
| ALL .... inhibition of topoisomerase II |
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Term
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Definition
| S phase....inhibition of topoisomerase I .... ovarian, lung, colorectal |
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Term
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Definition
| colorectal...inhibition of topoisomerase I |
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Term
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Definition
| ovarain, small cell lung, inhibition of topoisomerase I |
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Term
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Definition
| prodrug...methylates/breaks DNA ... MOPP .. resistance via inc repair |
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Term
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Definition
| camptothecin, irinotecan, topotecan |
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Term
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Definition
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