Term
|
Definition
1. peptidoglycan
2. membrane
3. DNA/RNA
4. prot. synth
5. energy changes |
|
|
Term
|
Definition
| mutation, acquire genetic material (conjugation...sex pili, transformation...umtake from env, transduction...bacteriophage) |
|
|
Term
|
Definition
| receptors (PCN/aminoglycosides), efflux (tetracyclines), influx (B-lactam), metabolism, resistant path (thymidine/sulfonamides), failure to activate (5FU) |
|
|
Term
|
Definition
| FAS-II (mycolic acid)....isonicotinic acid (active)....free....6 gene resistance |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Mycobacterial arabinosyl transferase (arabinoglycan).....opitic neuritis |
|
|
Term
|
Definition
| POA (active) FAS-I...dec. pH....selective to caseous lesions |
|
|
Term
|
Definition
| 30S ribosome..free only...nephro/oto toxic |
|
|
Term
|
Definition
| ergosterol binding....use test dose r/o siezures |
|
|
Term
|
Definition
| blocks thymidylate synthase.....cytosine spec permiase/ cytocine deaminase |
|
|
Term
|
Definition
| traizoles=selective to 14a demethylase (ergosterol synth) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| metaphase spindles, superficial dermatophyte infections |
|
|
Term
|
Definition
|
|
Term
|
Definition
| topical ergosterol binder |
|
|
Term
|
Definition
| aminoglycosides, B-lactam, isoniazid, pyrazinamide, quinolones, rifampin, vancomycin |
|
|
Term
|
Definition
| chloramphenicol, ethambutol, macrolides, sulfonamides, tetracycline |
|
|
Term
|
Definition
| 1->4 inc gram- activity, B-lactamase resistant, inc CSF |
|
|
Term
|
Definition
| G-, B-lactamase resistant, BROAD |
|
|
Term
|
Definition
| G- aerobic rods ONLY, B-lactamase resistant, |
|
|
Term
|
Definition
| MRSA, ototox, thrombophlebitis |
|
|
Term
|
Definition
| want inc crystal size, prodrug |
|
|
Term
| methenamine, naldixic acid |
|
Definition
| chronic UTI, acidifies urine (no resistance) |
|
|
Term
|
Definition
| quinalone related AB used for UTI |
|
|
Term
|
Definition
| streptofamins used in vancomycin resistant enterococci |
|
|
Term
|
Definition
| vancomycin resistant enterococci in repitory |
|
|
Term
|
Definition
| broad cell membrane dysruptor |
|
|
Term
|
Definition
|
|
Term
|
Definition
| active uptake to anaerobic bacteria, PRODRUG, DNA dysruption |
|
|
Term
|
Definition
| inc pH, active conc, heme metabolism |
|
|
Term
|
Definition
| passive conc (WB), heme breakdown |
|
|
Term
|
Definition
| alkylater, heme breakdown |
|
|
Term
|
Definition
| concentrated and alters heme breakdown |
|
|
Term
|
Definition
| toxic to babies, Contra w./ dec G6PD, metabolism dysrupter, ubiquinone |
|
|
Term
|
Definition
| mit. electron transport, ox/red stuff |
|
|
Term
|
Definition
| DNA gyrase inh, cart damage <18yoa, |
|
|
Term
|
Definition
| 30S, oto-,renal-toxic, curare-like NMB |
|
|
Term
|
Definition
| -static, G+/-...renal-,photo-,hepato-toxic, chelate |
|
|
Term
|
Definition
| 50S, legionairs, whooping cough, diptheria, chlamydia...safe |
|
|
Term
|
Definition
| broad, gray baby, anemia, bone marrow depression, used in typhoid fev, meningitis |
|
|
Term
| sulfonamides/trimtheoprim |
|
Definition
| sulph-dihydropteroate synthetase(PABA) trimeth-dihydrofolate synthetase |
|
|
Term
|
Definition
| DS DNA, 1=oral 2=genital .... CMV retinitis, VZV, karposi, mono.... |
|
|
Term
|
Definition
| guanosine derivative....blocks thymidine kinase......initial HSV1/2, VZV, CMV, |
|
|
Term
|
Definition
|
|
Term
|
Definition
| CMV retinitis, human papilloma virus |
|
|
Term
|
Definition
|
|
Term
|
Definition
| prodrug of penciclovir..oral |
|
|
Term
|
Definition
| HSV, shingles (VZV), ...topical |
|
|
Term
|
Definition
| intravitreal injection, CMV retinitis |
|
|
Term
|
Definition
| pyrophosphate, CMV, HSV, VZV |
|
|
Term
|
Definition
| guanine anolauge of acyclovir...CMV |
|
|
Term
|
Definition
|
|
Term
|
Definition
| pyrimidine derivative...optic herpes keratitis |
|
|
Term
|
Definition
| flu A treat/prevent....inhibits uncoating |
|
|
Term
|
Definition
|
|
Term
| respitory syncytial virus |
|
Definition
| ribavirin aerosol, palivizumab vaccine |
|
|
Term
|
Definition
| no treatment, is a vaccine |
|
|
Term
|
Definition
|
|
Term
|
Definition
| interferon alpha and ribavarin (teratogenic) |
|
|
Term
|
Definition
| prodrug...lactic acidosis....N/V |
|
|
Term
|
Definition
| block reverse transcriptase, active molecule |
|
|
Term
|
Definition
| effective...hyperglycemia, osteoporosis, LFT, metabolized by 3A4 |
|
|
Term
|
Definition
| SC BID $$$, limited use...enfuvirtide |
|
|
Term
|
Definition
| variola virus,,, vaccine avaliable, fever rash malaise lesions |
|
|
Term
|
Definition
| inhibits DNA synth in infected cells giving synergistic effect |
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